Results 71 to 80 of about 12,002 (336)

Investigating the mechanism of action of DNA-loaded PEGylated lipid nanoparticles [PDF]

, 2023
PEGylated lipid nanoparticles (LNPs) are commonly used to deliver bioactive molecules, but the role of PEGylation in DNA-loaded LNP interactions at the cellular and subcellular levels remains poorly understood.
Amenitsch, Heinz, Caracciolo, Giulio, Cardarelli, Francesco, De Lorenzi, Valentina, Digiacomo, Luca, Ferri, Gianmarco, Matteoli, Giulia, Pesce, Luca, Pozzi, Daniela, Quagliarini, Erica, Renzi, Serena   +10 more
core   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Multicomponent Antibiofilm Lipid Nanoparticles as Novel Platform to Ameliorate Resveratrol Properties: Preliminary Outcomes on Fibroblast Proliferation and Migration [PDF]

, 2023
: The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly.
Allegra, Mario, Angellotti, Giuseppe, Belfiore, Elena, Cancemi, Patrizia, D'Agostino, Fabio, De Caro, Viviana, Di Prima, Giulia, Peri, Emanuela, Tricoli, Maria Rita   +8 more
core   +1 more source

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

Communications Biology, 2022
Abstract Despite the overwhelming success of mRNA-based vaccine in protecting against SARS-CoV-2 infection and reducing disease severity and hospitalization, little is known about the role lipid nanoparticles (LNP) play in initiating immune response.
Jennifer Connors, David Joyner, Nathan J. Mege, Gina M. Cusimano, Matthew R. Bell, Jennifer Marcy, Bhavani Taramangalam, Kenneth M. Kim, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Michele A. Kutzler, Mohamad-Gabriel Alameh, Elias K. Haddad   +13 more
openaire   +4 more sources

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Mechanistic Modeling of Lipid Nanoparticle(Lnp) Precipitation Via Population Balance Equations (Pbes)

Chemical Engineering Journal
Lipid nanoparticles (LNPs) are precisely engineered drug delivery carriers commonly produced through controlled mixing processes, such as nanoprecipitation. Since their delivery efficacy greatly depends on particle size, numerous studies have proposed experimental and theoretical approaches for tuning LNP size.
Sunkyu Shin, Cedric Devos, Aniket Pradip Udepurkar, Pavan K. Inguva, Allan S. Myerson, Richard D. Braatz   +5 more
openaire   +2 more sources

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, EarlyView.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

Preparation and Characterization of Lipid Nanoparticles Co-loaded With DNA and Nitro-Oleic Acid

Bio-Protocol
Lipid nanoparticles (LNPs) are powerful carriers for nucleic acid delivery, but plasmid DNA-loaded LNPs (pDNA-LNPs) have been limited by inflammation and toxicity.
Manthan Patel, Sachchidanand Tiwari, Jacob Brenner   +2 more
doaj   +1 more source

Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach [PDF]

, 2023
Ionizable lipid nanoparticles (LNPs) have gained attention as mRNA delivery platforms for vaccination against COVID-19 and for protein replacement therapies.
Alameh, Mohamad-Gabriel, Gleghorn, Jason P, Hofbauer, Samuel I., Nelson, Katherine, Papachristou, Charalampos, Riley, Rachel S, Vijayakumar, Tara, Weissman, Drew, Young, Rachel E.   +8 more
core   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source