Results 111 to 120 of about 2,216,610 (312)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Worldwide Increasing Use of Nonfasting Rather Than Fasting Lipid Profiles

BACKGROUND: Historically, lipids and lipoproteins were measured in the fasting state for cardiovascular risk prediction; however, since 2009 use of nonfasting lipid profiles has increased substantially worldwide.
Nordestgaard, Børge G., Langsted, Anne
core   +1 more source

Phosphatidylserine and Sphingolipid Lipid Profiles in Placenta. Lipid Profiles in Placenta.

, 2016
Quantitative comparison of A) phosphatidylserine B) ceramide and C) sphingomyelin molecular lipid profiles in placenta between control (N = 68), PET (N = 23) and IUGR (N = 10). Values are shown as the mean of all measurements ± SEM.
Todd W. Mitchell (228801), Samuel R. Eather (3185178), Simon H. J. Brown (3185175), Barbara J. Meyer (707249), Dilys J. Freeman (3185181)   +4 more
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Association of Conventional and Unconventional Lipid Profiles with Visceral Fat Area in Overweight/Obese Individuals with Type 2 Diabetes Mellitus [PDF]

Xuan Ma,1,2,* Xinghe Jiang,1,* Guanqi Gao,2 Bo Ban,3 Jie Sheng,1,2 Shuwei Shi,1,2 Hongyan Zhao,1,2 Baolan Ji2 1School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, 261000, People’s Republic of China; 2Department of ...
Ji B, Sheng J, Shi S, Jiang X, Ma X, Gao G, Ban B, Zhao H   +7 more
core  

Lipid profiles and outcome in patients treated by intravenous thrombolysis for cerebral ischemia

, 2012
OBJECTIVE:To determine whether low low-density lipoprotein cholesterol (LDL-C) but not high-density lipoprotein cholesterol (HDL-C) and triglyceride concentrations are associated with worse outcome in a large cohort of ischemic stroke patients treated ...
Sarikaya, Hakan, Arnold, Marcel, Bordet, Régis, Engelter, Stefan, Gensicke, Henrik, Strbian, Daniel, Ford, Gary A, Soinne, Lauri, Cordonnier, Charlotte, Tatlisumak, Turgut, Baumgartner, Ralf W, Leys, Didier, Casoni, Federica, On behalf of the Lipid Profile in Thrombolysis Study Group,, Nardi, Katiuscia, Lyrer, Philippe, Duriez, Patrick, On behalf of the Lipid Profile in Thrombolysis Study Group   +17 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

High Density Lipoprotein from Egg Yolk (EYHDL) Improves Dyslipidemia by Mediating Fatty Acids Metabolism in High Fat Diet-induced Obese Mice

Food Science of Animal Resources, 2019
We investigated the effect of high density lipoprotein from egg yolk (EYHDL) on serum, hepatic and fecal lipid and fatty acids (FAs) levels and on gene expression involved in FAs metabolism.
Zhihui Yu, Changyi Mao, Xing Fu, Meihu Ma   +3 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source