Results 101 to 110 of about 75,466 (278)
Cholesterol, lipid rafts, and disease [PDF]
Journal of Clinical Investigation, 2002 Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in eukaryotic cells.
Simons, K., Ehehalt, R.
openaire +3 more sources
Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source
Rafts defined: a report on the Keystone symposium on lipid rafts and cell function
Journal of Lipid Research, 2006 The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts.
Linda J. Pike
doaj +1 more source
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, EarlyView.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2011 White matter injury characterized by damage to myelin is an important process in hypoxic-ischemic brain damage (HIBD). Because the oligodendrocyte-specific isoform of neurofascin, neurofascin 155 (NF155), and its association with lipid rafts are ...
Y.P. Zhang +4 more
doaj +1 more source
Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency
Advanced Science, EarlyView.Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu +23 more
wiley +1 more source
Association of NaV1.8 with lipid rafts in DRG sensory neurons
, 2011 Voltage gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neuronal cells. NaV1.8 is a Tetrodotoxin resistant VGSC expressed in nociceptors and underlies the majority of sodium currents during action
Pristera, Alessandro +1 more
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Advanced Science, EarlyView.Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu +14 more
wiley +1 more source
The Role of Lipid Rafts in Cancer Cell Adhesion and Migration
International Journal of Cell Biology, 2012 Lipid rafts are cholesterol-enriched microdomains of the cell membrane and possess a highly dynamic nature. They have been involved in various cellular functions including the regulation of cell adhesion and membrane signaling through proteins within ...
Toshiyuki Murai
doaj +1 more source
The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins
Pathogens, 2017 Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications.
Aabha I. Sharma +2 more
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