Results 1 to 10 of about 64,062 (299)

Differential Association of the Na+/H+ Exchanger Regulatory Factor (NHERF) Family of Adaptor Proteins with the Raft- and the Non-Raft Brush Border Membrane Fractions of NHE3 [PDF]

Cellular Physiology and Biochemistry, 2013
Background/Aims: Trafficking, brush border membrane (BBM) retention, and signal-specific regulation of the Na+/H+ exchanger NHE3 is regulated by the Na+/H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adaptor proteins, which enable the formation of ...
Ayesha Sultan, Min Luo, Qin Yu, Brigitte Riederer, Weiliang Xia, Mingmin Chen, Simone Lissner, Johannes E. Gessner, Mark Donowitz, C. Chris Yun, Hugo deJonge, Georg Lamprecht, Ursula Seidler   +12 more
doaj   +11 more sources

Transmembrane Domain Length of Influenza a Virus M2 Does Not Determine Its Non-Lipid Raft Localization [PDF]

Viruses
Influenza A virus expresses three envelope proteins, hemagglutinin (HA), neuraminidase (NA), and matrix protein 2 (M2). Of these, HA and NA associate with lipid rafts, whereas M2 remains in the peri-raft region.
Rashid Manzoor, Kosuke Okuya, Reiko Yoshida, Hiroko Miyamoto, Ayato Takada   +4 more
doaj   +2 more sources

Primary cilia and lipid raft dynamics [PDF]

Open Biology, 2021
Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura, Daishi Yamakawa, Katsunori Uchida, Takashi Shiromizu, Masatoshi Watanabe, Masaki Inagaki   +5 more
doaj   +2 more sources

Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs [PDF]

Membranes
The primary mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is inhibition of prostaglandin production mediated by cyclooxygenase. Given the possible association of cyclooxygenase-2, but not cyclooxygenase-1, with membrane lipid rafts, we ...
Maki Mizogami, Hiroki Iida, Hironori Tsuchiya   +2 more
doaj   +2 more sources

Toluidine Blue for the Determination of Binding of Anionic Polysaccharides to Lipid Raft Domains by Absorption Spectroscopy [PDF]

Membranes
The complexes of negatively charged polysaccharides with lipid vesicles have been shown to have applications in medicine, bioremediation, water purification, and construction of nano-biosensors.
Sandra Gębczyńska, Julia Gdowska, Agata Mikos, Iga Gawrońska, Teresa Janas, Aleksander Czogalla, Tadeusz Janas   +6 more
doaj   +2 more sources

ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferring proteins for rapid ER export [PDF]

Nature Communications
The determinants of sub-cellular trafficking for many membrane proteins are poorly understood. Lipid-driven membrane nanodomains known as lipid rafts have been widely implicated in post-Golgi traffic, but their involvement in protein sorting in the ...
Ivan Castello-Serrano, Shikha Dagar, Rossana Ippolito, Kandice R. Levental, Ilya Levental   +4 more
doaj   +2 more sources

Transcriptomic landscape based on annotated clinical features reveals PLPP2 involvement in lipid raft-mediated proliferation signature of early-stage lung adenocarcinoma [PDF]

Journal of Experimental & Clinical Cancer Research, 2023
Background Image-based screening improves the detection of early-stage lung adenocarcinoma (LUAD)but also highlights the issue of high false-positive diagnoses, which puts patients at a risk of unnecessary over-treatment.
Yibei Wang, Ziwei Miao, Xiaoxue Qin, Yi Yang, Si Wu, Qi Miao, Beibei Li, Mingyu Zhang, Pengfei Wu, Yun Han, Bo Li   +10 more
doaj   +2 more sources

α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis

Frontiers in Cell and Developmental Biology, 2021
BackgroundNicotine exerts direct effects on multiple cell types in the cardiovascular system by associating with its high-affinity nicotinic acetylcholine receptors (nAchRs).
Fengqi Duan, Cheng Zeng, Sijun Liu, Jianfeng Gong, Jia Hu, Hongyu Li, Hongmei Tan, Hongmei Tan, Hongmei Tan   +8 more
doaj   +1 more source

Cold induces micro- and nano-scale reorganization of lipid raft markers at mounds of T-cell membrane fluctuations. [PDF]

PLoS ONE, 2009
Whether and how cold causes changes in cell-membrane or lipid rafts remain poorly characterized. Using the NSOM/QD and confocal imaging systems, we found that cold caused microscale redistribution of lipid raft markers, GM1 for lipid and CD59 for protein,
Yong Chen, Jie Qin, Jiye Cai, Zheng W Chen   +3 more
doaj   +1 more source

Interaction of drugs with lipid raft membrane domains as a possible target

Drug Target Insights, 2020
Introduction: Plasma membranes are not the homogeneous bilayers of uniformly distributed lipids but the lipid complex with laterally separated lipid raft membrane domains, which provide receptor, ion channel and enzyme proteins with a platform.
Hironori Tsuchiya, Maki Mizogami
doaj   +1 more source