Results 1 to 10 of about 57,321 (288)

Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment

Pharmacological Research
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis.
Qiuju Wang, Man Lu
exaly   +3 more sources

Using BODIPY FL-Sphingolipid Analogs to Study Sphingolipid Metabolism in Mouse Embryonic Stem Cells

Bio-Protocol, 2022
Sphingolipids are important structural components of cellular membranes. They also function as prominent signaling molecules to control a variety of cellular events, such as cell growth, differentiation, and apoptosis.
Wei Fan, Xiaoling Li
doaj   +1 more source

A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites

Cells, 2021
Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration.
Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir   +3 more
doaj   +1 more source

Plasma Sphingolipid Profile Associated With Subclinical Atherosclerosis and Clinical Disease Markers of Systemic Lupus Erythematosus: Potential Predictive Value

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects females more than males, with African Americans developing more severe manifestation of the disease.
Samar M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates, Jim C. Oates   +6 more
doaj   +1 more source

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
doaj   +1 more source

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Cells, 2022
The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal   +9 more
doaj   +1 more source

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.

PLoS Genetics, 2020
Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J Heinisch, Christer S Ejsing, Bruno André, Florian Fröhlich   +10 more
doaj   +1 more source

The Manifold Roles of Sphingolipids in Viral Infections

Frontiers in Physiology, 2021
Sphingolipids are essential components of eukaryotic cells. In this review, we want to exemplarily illustrate what is known about the interactions of sphingolipids with various viruses at different steps of their replication cycles.
Elita Avota, Jochen Bodem, Janice Chithelen, Putri Mandasari, Niklas Beyersdorf, Jürgen Schneider-Schaulies   +5 more
doaj   +1 more source

Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]

Journal of Lipid Research, 2018
Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate.
Justin M. Snider, Ashley J. Snider, Lina M. Obeid, Chiara Luberto, Yusuf A. Hannun   +4 more
doaj   +1 more source

Altered expression of glycobiology-related genes in Parkinson’s disease brain

Frontiers in Molecular Neuroscience, 2022
The precise mechanisms initiating and perpetuating the cellular degeneration in Parkinson’s disease (PD) remain unclear. There is decreased expression of the main brain gangliosides, and GM1 ganglioside in particular, in the PD brain along with decreased
Jay S. Schneider, Garima Singh
doaj   +1 more source