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Sphingolipid transport
, 2010 Sphingolipids are a family of ubiquitous membrane components that exhibit multiple functional properties fundamental to cell properties. Sphingolipid transport represents a crucial aspect in the metabolism, signaling and biological role of sphingolipids. P. Giussani, P. Viani, Paola Viani, Laura Riboni, L. Riboni, Paola Giussani +5 morecore +3 more sourcesSphingolipids [PDF]
Kidney International, 2000 A significant corpus of work over the last decade has firmly established an important role for sphingolipids in a variety of important biological processes. Such processes include signaling events related to cell growth, differentiation, programmed cell death, and stress responses. These processes not only involve those sphingolipids that accumulate as Alfred Merrill, Eva-Marie Schmelzopenaire +3 more sourcesSingle-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia. [PDF]
Adv Sci (Weinh)This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.Luo D, Zhan Y, Ji L, Xu P, Chen P, Pang H, Ling Y, Hua F, Zhuang X, Chen H, Cheng Y. +10 moreeuropepmc +2 more sourcesSphingolipid and ceramide homeostasis : potential therapeutic targets [PDF]
, 2012 Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith +15 morecore +1 more sourceGenetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]
, 2009 Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.S. Campbell, Aulchenko, Y.S. (Yurii), Igl, Wilmar,, Zaboli, Ghazal, Polasek, O. (Ozren), A. Wright, J. F. Wilson, Gyllensten, U, Hicks, Andrew A, Schwienbacher, C, Hengstenberg, Christian, I. R. König, Peter Ugocsai, A. Demirkan, C. Pattaro, Wichmann, H.-E., G. Liebisch, Peters, Annette, Kirichenko, Anatoly V, Liebisch, G, Peters, A. (Annette), Witteman, Jacqueline C. M., Wright, Alan, C. Hengstenberg, O. Polasek, König, Inke R, P. Ugocsai, Janssens, A. Cecilej W., Hayward, C., Campbell, Harry, Campbell, H, Pichler, I. (Irene), Pichler, I., Gerhard Liebisch, Demirkan, A., Campbell, S, Biloglav, Z. (Zrinka), P. P. Pramstaller, Kolcic, I, Johansson, Asa, Liebisch, Gerhard, C. M. van, Wichmann, H.E. (Heinz Erich), Janssens, A Cecilej W, Meitinger, T., Wild, SH, Ozren Polasek, Igl, W., Jeanette Erdmann, Schmitz, G, Franklin, CS, S. Schreiber, Jonasson, I, Wichmann, H-Erich, Ugocsai, P, Polsek, Ozren, Wichmann, H.-Erich, Cornelia M van Duijn, Hengstenberg, C, Erdmann, J. (Jeanette), H. Campbell, König, I.R. (Inke), Axenovich,T.I., G. Schmitz, Y. Aulchenko, S. H. Wild, Schreiber, Stefan, Gyllensten, Ulf,, Campbell, Harry; id_orcid, I. Rudan, G. Zaboli, Schreiber, S., Ivana Kolcic, Johansson, A, Wright, A, Franklin, Christopher S, Kolcic, I., Zorkoltseva, I.V. (Irina), Wilson, J.F., Rudan, I. (Igor), Johansson, A. (Åsa), Zorkoltseva, I.V., Schwienbacher, Christine, Duijn, Cornelia, Marroni, Fabio, Witteman, Jacqueline C M, Fabio Marroni, Zaboli, Ghazal,, Jonasson, Inger, Hicks, A.A. (Andrew), Irene Pichler, Gyllensten, U., Campbell, H., Wichmann, HE, A Cecilej W Janssens, Pramstaller, P.P. (Peter Paul), Janssens, A.C., Peters, A., Wild, S.H., Isaacs, A., Pichler, Irene, Vitart, Veronique, N. Hastie, Tatiana I Axenovich, Johansson, Åsa,, I. Kolcic, Ghazal Zaboli, James F Wilson, Kolcic, I. (Ivana), Wilson, James F; id_orcid, Biloglav, Zrinka, Ugocsai, P. (Peter), Gnewuch, C., A. Johansson, Zaboli, G., Marroni, F, Andrew A Hicks, Pattaro, C., Pichler, I, Christian Hengstenberg, Jacqueline C M Witteman, Schunkert, H, Biloglav, Z, Caroline Hayward, Pattaro, Cristian, C. Hayward, Koenig, Inke R., Zrinka Biloglav, Demirkan, A. (Ayşe), Liebisch, G., J. Erdmann, Franklin, C.S. (Christopher), I. V. Zorkoltseva, U. Gyllensten, Alan Wright, Pattaro, C, Franklin, Christopher S., Hengstenberg, C. (Christian), A. V. Kirichenko, Harry Campbell, Schunkert, H., W. Igl, Hastie, N., Ulf Gyllensten, C. Schwienbacher, Kirichenko, AV, Demirkan, Ayse, Janssens, A. CecileJ.W., Schreiber, S, Wild, S.H. (Sarah), Zorkoltseva, IV, Schwienbacher, C. (Christine), Erdmann, Jeanette, Yurii Aulchenko, Asa Johansson, Ben A Oostra, Aulchenko, Y., Veronique Vitart, Liebisch, G. (Gerhard), B. A. Oostra, Janssens, Cecile, Christine Schwienbacher, Hastie, N, A. C. W, Rudan, Igor, Igl, W. (Wilmar), I. Pichler, Erdmann, J., C. Gnewuch, Konig, IR, Anatoly V Kirichenko, Schwienbacher, C., van Duijn, C.M., Jonasson, I., Kirichenko, A.V. (Anatoly), Schmitz, G., Hicks, Andrew A., A. A. Hicks, Susan Campbell, Annette Peters, Gerd Schmitz, Hayward, Caroline, Zorkoltseva, Irina V, Witteman, JCM, T. I. Axenovich, Gnewuch, C, König, I.R., Carsten Gnewuch, H. Wichmann, Gyllensten, Ulf, Igl, Wilmar, Meitinger, T, Kirichenko, Anatoly V., H-Erich Wichmann, Cristian Pattaro, C. S. Franklin, Gnewuch, Carsten, König, Inke R., Isaacs, A.J. (Aaron), Erdmann, J, Zaboli, G. (Ghazal), Christopher S Franklin, Campbell, S., Irina V Zorkoltseva, Zorkoltseva, Irina V., Hengstenberg, C., Zaboli, G, Hicks, A.A., Peter P Pramstaller, Marroni, F. (Fabio), Sarah H Wild, Ayse Demirkan, Johansson, A., Wright, A., Hicks, AA, Wichmann, Heinz-Erich, Nick Hastie, Hastie, Nick, H. Schunkert, Polasek, Ozren, Janssens, A. Cecile J. W., Inger Jonasson, Axenovich, TI, Polasek, O., Peters, A, Oostra, Ben A., Oostra, B.A., Wright, A.F. (Alan), Axenovich, T.I. (Tatiana), van Duijn, Cornelia M., Heribert Schunkert, Vitart, V. (Veronique), Hastie, N. (Nick), Wild, Sarah H; id_orcid, Schmitz, Gerd, Hayward, C. (Caroline), Biloglav, Z., Schunkert, H. (Heribert), Campbell, S. (Susan), A. Peters, Ugocsai, Peter, T. Meitinger, Oostra, Ben, Inke R König, Kolcic, Ivana, Stefan Schreiber, Gibson, Greg, Schunkert, Heribert, Z. Biloglav, Rudan, I., Isaacs, Aaron, V. Vitart, Tikka-Kleemola, P. (Päivi), Wilson, JF, Oostra, B.A. (Ben), Franklin, C.S., Jonasson, I. (Inger), Wilson, James F., Schreiber, S. (Stefan), Pramstaller, Peter P, Rudan, I, Wild, Sarah H., Schmitz, G. (Gerd), Janssens, A.C.J.W. (Cécile), Oostra, Ben A, Vitart, V, Meitinger, Thomas, Vitart, V., Aulchenko, Yurii, Pramstaller, PP, Gnewuch, C. (Carsten), Marroni, F., Campbell, Susan, Axenovich, Tatiana I., Hayward, C, Witteman, J.C.M. (Jacqueline), J. C. M, Wilmar Igl, Igl, W, Axenovich, Tatiana I, Kirichenko, A.V., Aulchenko, Yuriy, Wilson, J.F. (James), Gyllensten, U. (Ulf), van Duijn, Cornelia M, Meitinger, T. (Thomas), Hayward, Caroline; id_orcid, Thomas Meitinger, Ugocsai, P., Pattaro, C. (Cristian), Polasek, O, I. Jonasson, Pramstaller, Peter P., Aaron Isaacs, Igor Rudan, Witteman, J.C., Jonasson, Inger,, A. Isaacs, Pramstaller, P.P., Wild S. H., Schmitz G., Hastie Nick, Schreiber S., Campbell Susan, Peters Annette, Erdmann Jeanette, Wright A., Oostra B. A., Vitart Veronique, Zorkoltseva I. V, Witteman J. C., Johansson A, Zaboli Ghazal, Schreiber Stefan, Ugocsai P, König I. R., Pichler I., Liebisch Gerhard, Aulchenko Y, Hastie N., Pattaro C, Wild Sarah H., Zaboli G., Aulchenko Yurii, Isaacs A., Wichmann H. E., Hicks, AA;Pramstaller, PP;Johansson, Å;Vitart, V;Rudan, I;Ugocsai, P;Aulchenko, Y;Franklin, CS;Liebisch, G;Erdmann, J;Jonasson, I;Zorkoltseva, IV;Pattaro, C;Hayward, C;Isaacs, A;Hengstenberg, C;Campbell, S;Gnewuch, C;Janssens, AC;Kirichenko, AV;König, IR;Marroni, F;Polasek, O;Demirkan, A;Kolcic, I;Schwienbacher, C;Igl, W;Biloglav, Z;Witteman, JC;Pichler, I;Zaboli, G;Axenovich, TI;Peters, A;Schreiber, S;Wichmann, HE;Schunkert, H;Hastie, N;Oostra, BA;Wild, SH;Meitinger, T;Gyllensten, U;van Duijn, CM;Wilson, JF;Wright, A;Schmitz, G;Campbell, H, Schmitz Gerd, Kolcic Ivana, Campbell S., Schunkert H., Gyllensten U., Franklin Christopher S., Demirkan A., Liebisch G, Axenovich T. I., Rudan Igor, Witteman Jacqueline C. M., Wichmann H.-Erich, Hengstenberg Christian, Pramstaller PP, van Duijn Cornelia M., Oostra Ben A., Rudan I, Vitart V, Kolcic I., Ugocsai Peter, Gnewuch C., Franklin CS, Gyllensten Ulf, Biloglav Zrinka, Wilson James F., Igl Wilmar, Marroni F., Schunkert Heribert, van Duijn C. M., Zorkoltseva Irina V., Meitinger T., Meitinger Thomas, Kirichenko Anatoly V., Pichler Irene, Janssens A. C., Campbell H., Jonasson Inger, Biloglav Z., Peters A., Johansson Åsa, Hicks Andrew A., Demirkan Ayse, Isaacs Aaron, Hayward C., Hayward Caroline, Jonasson I, Kirichenko A. V., Erdmann J, Igl W., Schwienbacher Christine, Axenovich Tatiana I., Marroni Fabio, Polasek O., Pramstaller Peter P., Janssens A. CecileJ.W., Hicks AA, Pattaro Cristian, Polasek Ozren, Wilson J. F., Wright Alan, Gnewuch Carsten, Campbell Harry, Hengstenberg C., König Inke R. +390 morecore +2 more sourcesSphingolipids in Inflammation [PDF]
Mediators of Inflammation, 2018 The etiology of many diseases results from the dysregulation of inflammation. Understanding the molecular mechanisms controlling the inflammatory response is essential to formulate therapeutic strategies for the treatment of inflammatory conditions. In fact, substantial research has unveiled important aspects of the inflammatory machinery, both at the ...Elisabetta Albi, Alice Alessenko, Sabine Grösch +2 moreopenaire +4 more sourcesSphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii [PDF]
, 2012 Sphingolipids are essential components of eukaryotic cell membranes, particularly the plasma membrane, and are involved in a diverse array of signal transduction pathways.Steven Pratt, Nilu Wansadhipathi-Kannangara, Catherine Bruce, Hosam Shams-Eldin, Paul Denny, Sabrina Sonda, John Mina, Josefina Casas, Kentaro Hanada, Ralph T. Schwarz +9 morecore +3 more sources
