Results 41 to 50 of about 52,400 (306)

Sphingolipid biosynthesis in Physcomitrella patens [PDF]

, 2020
The complex sphingolipid classes glycosylceramides (GlcCers) and glycosyl inositolphosphorylceramides (GIPCs) are essential membrane components in plant cells. However, the regulation of their synthesis and their distinct physiological roles in plants is
Gömann, Jasmin
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tubercidin enhances apoptosis in serum-starved and hypoxic mouse cardiomyocytes by inducing nuclear speckle condensation

BMC Cardiovascular Disorders
Tubercidin, known for its antimicrobial, antiparasitic, and anticancer effects, faces clinical limitations due to adverse effects, especially cardiotoxicity risks for those with ischemic cardiomyopathy.
Guowen Shen, Qingni Cheng, Lunmin Liang, Yaping Qin, Yunzhu Cao, Quanzhong Li, Shengjun Xiao   +6 more
doaj   +1 more source

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

mBio
Sphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis.
Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U. Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation

Journal of Lipid Research
The Orm family of proteins inhibit serine palmitoyltransferase—the enzyme that catalyzes the first step in sphingolipid synthesis. In S. cerevisiae, the two Orm proteins are thought to function redundantly in suppressing sphingolipid production. Here, we
Jihui Ren, Yusuf A. Hannun
doaj   +1 more source

Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection

Frontiers in Cardiovascular Medicine, 2021
Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD.
Huang Huang, Guozhu Ye, Song-qing Lai, Hua-xi Zou, Bin Yuan, Qi-cai Wu, Li Wan, Qun Wang, Xue-liang Zhou, Wen-jun Wang, Yuan-ping Cao, Jian-feng Huang, Shi-li Chen, Bi-cheng Yang, Ji-chun Liu   +14 more
doaj   +1 more source

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and a drug target [PDF]

, 2009
Sphingolipids are important structural components of eukaryotic membranes, in addition they and their precursors are involved in signal transduction processes.
Pan, Ssu-Ying
core