Results 41 to 50 of about 57,321 (288)

Functional Characterization of a Higher Plant Sphingolipid Δ4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis [PDF]

, 2008
The role of Δ4-unsaturated sphingolipid long-chain bases such as sphingosine was investigated in Arabidopsis (Arabidopsis thaliana). Identification and functional characterization of the sole Arabidopsis ortholog of the sphingolipid Δ4-desaturase was ...
Warnecke, D., Sperling, Petra, Haslam, Richard P., Mugford, S., Napier, Johnathan A., Sperling, P., Sarah Mugford, Albrecht, S., Johnathan A. Napier, Petra Sperling, Richard P. Haslam, Simone Zäuner, Michaelson, L. V., Desikan, R., Haslam, R. P., Sandra Albrecht, Radhika Desikan, Dirk Warnecke, Albrecht, Sandra, Markham, J. E., Heinz, E., Warnecke, Dirk, E. Heinz, Desikan, Radhika, Michaelson, Louise V., Louise V. Michaelson, Markham, Jennifer E., Zauner, S., Zäuner, Simone, Napier, J. A., Mugford, Sarah, Jennifer E. Markham   +31 more
core   +1 more source

Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter

Biomolecules, 2018
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for ...
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J. Barrantes, Henri Chahinian   +4 more
doaj   +1 more source

Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant Candida glabrata

Marine Drugs, 2021
Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant Candida glabrata at 10 μg/mL (15.4 μM).
Doralyn S. Dalisay, Evan W. Rogers, Tadeusz F. Molinski   +2 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Tubercidin enhances apoptosis in serum-starved and hypoxic mouse cardiomyocytes by inducing nuclear speckle condensation

BMC Cardiovascular Disorders
Tubercidin, known for its antimicrobial, antiparasitic, and anticancer effects, faces clinical limitations due to adverse effects, especially cardiotoxicity risks for those with ischemic cardiomyopathy.
Guowen Shen, Qingni Cheng, Lunmin Liang, Yaping Qin, Yunzhu Cao, Quanzhong Li, Shengjun Xiao   +6 more
doaj   +1 more source

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

mBio
Sphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis.
Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U. Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante   +9 more
doaj   +1 more source

Molecular Classification of Genes Associated with Hypoxic Lipid Metabolism in Pancreatic Cancer

Biomolecules, 2022
Abnormal lipid metabolism often occurs under hypoxic microenvironment, which is an important energy supplement for cancer cell proliferation and metastasis.
Yaning Li, Xinyue Liang, Gang Che, Yutong Chen, Lisi Luo, Kecheng Liu, Rongzhi Xie, Linjuan Zeng   +7 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Sphingolipids in Neurodegeneration [PDF]

NeuroMolecular Medicine, 2010
Although the brain contains a high content of sphingolipids, we know relatively little about the roles that sphingolipids play in regulating neural functions. Once regarded only for their structural roles in maintaining the integrity of cellular and sub-cellular compartments, it is now apparent that many sphingolipid species are biologically active and
openaire   +2 more sources

Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation

Journal of Lipid Research
The Orm family of proteins inhibit serine palmitoyltransferase—the enzyme that catalyzes the first step in sphingolipid synthesis. In S. cerevisiae, the two Orm proteins are thought to function redundantly in suppressing sphingolipid production. Here, we
Jihui Ren, Yusuf A. Hannun
doaj   +1 more source