Results 51 to 60 of about 57,321 (288)

Single-cell sequencing analysis related to sphingolipid metabolism guides immunotherapy and prognosis of skin cutaneous melanoma

Frontiers in Immunology, 2023
BackgroundWe explore sphingolipid-related genes (SRGs) in skin melanoma (SKCM) to develop a prognostic indicator for patient outcomes. Dysregulated lipid metabolism is linked to aggressive behavior in various cancers, including SKCM.
Yantao Ding, Yantao Ding, Yantao Ding, Zhijie Zhao, Huabao Cai, Yi Zhou, Yi Zhou, Yi Zhou, He Chen, Yun Bai, Zhenran Liu, Shengxiu Liu, Shengxiu Liu, Shengxiu Liu, Wenming Zhou, Wenming Zhou, Wenming Zhou   +16 more
doaj   +1 more source

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and a drug target [PDF]

, 2009
Sphingolipids are important structural components of eukaryotic membranes, in addition they and their precursors are involved in signal transduction processes.
Pan, Ssu-Ying
core  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia[S]

Journal of Lipid Research, 2010
Synthesis of glucosylceramide via glucosylceramide synthase (GCS) is a crucial event in higher eukaryotes, both for the production of complex glycosphingolipids and for regulating cellular levels of ceramide, a potent antiproliferative second messenger ...
Saša Štefanić, Cornelia Spycher, Laura Morf, Gemma Fabriàs, Josefina Casas, Elisabeth Schraner, Peter Wild, Adrian B. Hehl, Sabrina Sonda   +8 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Sphingolipid Signaling Mediates Iron Toxicity [PDF]

, 2012
SummaryIron constitutes a major source of toxicity due to its ability to generate reactive oxygen species that can damage cellular macromolecules. However, the precise mechanism by which exposure to high iron concentrations results in cellular toxicity ...
Chanfreau, Guillaume F., Kropat, Janette, Dickson, Robert C., Henras, Anthony, Lee, Yueh-Jung, Huang, Xinhe, Merchant, Sabeeha S.   +6 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Removal of the Sphingolipid impurity from preparations of yeast phosphatidyl inositol

Journal of Lipid Research, 1967
A complex sphingolipid containing inositol and mannose, present in lipid extracted from toluene-autolyzed baker's yeast, was eluted from silicic acid columns immediately after phosphatidyl inositol, and was the main nitrogenous impurity in crude ...
William E. Trevelyan
doaj   +1 more source

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Toxins, 2021
Fumonisins (FB) are mycotoxins known to exert most of their toxicity by blocking ceramide synthase, resulting in disruption of sphingolipid metabolism.
Didier Tardieu, Maria Matard-Mann, Pi Nyvall Collén, Philippe Guerre   +3 more
doaj   +1 more source

Rice ORMDL controls sphingolipid homeostasis affecting fertility resulting from abnormal pollen development. [PDF]

, 2014
The orosomucoids (ORM) are ER-resisdent polypeptides encoded by ORM and ORMDL (ORM-like) genes. In humans, ORMDL3 was reported as genetic risk factor associated to asthma.
Kanidta Sangsawang, Chunthong, K., Suksangpanomrung, M., Malinee Suksangpanomrung, Amorntip Muangprom, Sriprapai Chakhonkaen, Sriprapai Chakhonkaen (626315), Johnathan A Napier, Chakhonkaen, S., Pitnjam, K., Muangprom, A., Numphet Sangarwut, Chutharat Chueasiri (626312), Keasinee Pitnjam, Louise V. Michaelson (626319), Sangsawang, K., Kanidta Sangsawang (626317), Sangarwut, N., Amorntip Muangprom (626321), Louise V Michaelson, Michaelson, L. V., Chueasiri, C., Keasinee Pitnjam (626314), Ketsuwan Chunthong, Johnathan A. Napier (626320), Malinee Suksangpanomrung (626318), Ketsuwan Chunthong (626313), Napier, J. A., Chutharat Chueasiri, Numphet Sangarwut (626316)   +29 more
core   +1 more source