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A commensal protozoan exacerbates acetaminophen-induced liver injury by producing free sphingosine [PDF]
Gut MicrobesThe mechanisms by which the gut microbiota influence host disease outcomes remain poorly understood. As an integral yet overlooked component of this microbial community, the role of gut commensal protists in host physiology and pathology is even more ...
Xiaoqing Yan +13 more
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Michael Maceyka, Sarah Spiegel
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Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Biochimica Et Biophysica Acta - Biomembranes, 2006 Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological functions, including regulation of cell growth and survival. Cer and Sph are associated with growth arrest and apoptosis.
Nitai C Hait +2 more
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Journal of Lipid Research, 2023 Sphingolipids like sphingosine-1-phosphate (S1P) have been implicated in the pathophysiology of pre-eclampsia. We hypothesized that plasma S1P would be increased in women at high risk of developing pre-eclampsia who subsequently develop the disease.
Edward D. Johnstone +6 more
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FEBS Open Bio, 2021 Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4.
Tomotaka Nagasawa +5 more
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1-磷酸鞘氨醇在缺血性卒中中的作用研究进展 Research Progress on the Role of Sphingosine 1-Phosphate in Ischemic Stroke
Zhongguo cuzhong zazhi, 2023 脑组织缺血坏死后释放出炎性因子诱发炎症反应，并激活神经胶质细胞参与损伤后的级联免疫反应，1-磷酸鞘氨醇（sphingosine 1-phosphate，S1P）代谢与缺血性卒中具有相关性，神经胶质细胞在炎症状态下上调1-磷酸鞘氨醇受体（sphingosine 1-phosphate receptors，S1PRs）的表达，S1PRs发出S1P信号参与脑组织中炎症介质的上调，S1P与S1PRs结合参与缺血性卒中后炎症和免疫反应、内皮细胞的黏附和血管生成以及改善血脑屏障功能 ...
李萍，付胜奇
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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [PDF]
Advances in Biological Regulation, 2016 Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses.
Pyne, Nigel J. +8 more
openaire +5 more sources
Sphingolipids as Modulators of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole.
Kid Törnquist +7 more
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Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs
Toxins, 2020 Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance.
Zhong-Xing Rao +6 more
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A Brief Review of FT-IR Spectroscopy Studies of Sphingolipids in Human Cells
Biophysica, 2023 In recent years, sphingolipids have attracted significant attention due to their pivotal role in cellular functions and physiological diseases.
Bahar Faramarzi +4 more
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