Results 1 to 10 of about 47,077 (228)
Journal of Lipid Research, 2023 Sphingolipids like sphingosine-1-phosphate (S1P) have been implicated in the pathophysiology of pre-eclampsia. We hypothesized that plasma S1P would be increased in women at high risk of developing pre-eclampsia who subsequently develop the disease.
Edward D. Johnstone +6 more
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FEBS Open Bio, 2021 Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4.
Tomotaka Nagasawa +5 more
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1-磷酸鞘氨醇在缺血性卒中中的作用研究进展 Research Progress on the Role of Sphingosine 1-Phosphate in Ischemic Stroke
Zhongguo cuzhong zazhi, 2023 脑组织缺血坏死后释放出炎性因子诱发炎症反应，并激活神经胶质细胞参与损伤后的级联免疫反应，1-磷酸鞘氨醇（sphingosine 1-phosphate，S1P）代谢与缺血性卒中具有相关性，神经胶质细胞在炎症状态下上调1-磷酸鞘氨醇受体（sphingosine 1-phosphate receptors，S1PRs）的表达，S1PRs发出S1P信号参与脑组织中炎症介质的上调，S1P与S1PRs结合参与缺血性卒中后炎症和免疫反应、内皮细胞的黏附和血管生成以及改善血脑屏障功能 ...
李萍，付胜奇
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Sphingolipids as Modulators of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole.
Kid Törnquist +7 more
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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [PDF]
Advances in Biological Regulation, 2016 Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses.
Pyne, Nigel J. +8 more
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Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs
Toxins, 2020 Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance.
Zhong-Xing Rao +6 more
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A Brief Review of FT-IR Spectroscopy Studies of Sphingolipids in Human Cells
Biophysica, 2023 In recent years, sphingolipids have attracted significant attention due to their pivotal role in cellular functions and physiological diseases.
Bahar Faramarzi +4 more
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Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 Infection
The Thoracic & Cardiovascular Surgeon Reports, 2022 Background The majority of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection present mild symptoms. However, some patients develop severe acute respiratory distress syndrome (ARDS) and subsequent irreversible lung ...
Achim Koch +6 more
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Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat
Frontiers in Immunology, 2017 Sepsis is not only a significant cause of mortality worldwide but has particularly devastating effects on the central nervous system of survivors. It is therefore crucial to understand the molecular structure, physiology, and events involved in the ...
Stephen J. Kuperberg, Raj Wadgaonkar
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A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane
Journal of Lipid Research, 2023 The role of ceramide in biological functions is typically based on the elevation of cellular ceramide, measured by LC-MS in the total cell lysate. However, it has become increasingly appreciated that ceramide in different subcellular organelles regulates
Meaghan Greene +4 more
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