Results 1 to 10 of about 26,961 (163)
The Functional Role of Sphingosine Kinase 2 [PDF]
Frontiers in Molecular Biosciences, 2021 Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and
Rocio Diaz Escarcega +5 more
doaj +3 more sources
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [PDF]
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2013 Sphingosine 1-phosphate (S1P) is an important bioactive sphingolipid metabolite that has been implicated in numerous physiological and cellular processes. Not only does S1P play a structural role in cells by defining the components of the plasma membrane, but in the last 20 years it has been implicated in various significant cell signaling pathways and
K Alexa Orr Gandy, Lina M Obeid
exaly +3 more sources
Transcriptional Regulation of Sphingosine Kinase 1 [PDF]
Cells, 2020 Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways.
Joseph Bonica +3 more
doaj +3 more sources
The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy [PDF]
Epilepsia OpenEpilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang +4 more
doaj +2 more sources
Drugging Sphingosine Kinases [PDF]
ACS Chemical Biology, 2014 The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2. SphK is a key regulator of S1P and the S1P:Sph/ceramide ratio.
Santos, Webster L., Lynch, Kevin R.
openaire +2 more sources
Effects of sphingolipid metabolism disorders on endothelial cells
Lipids in Health and Disease, 2022 Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai +4 more
doaj +1 more source
Sphingosine Kinases as Druggable Targets [PDF]
, 2018 There is substantial evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid sphingosine 1-phosphate, are involved in pathophysiological processes. In this chapter, we appraise the evidence that both enzymes are druggable and describe how isoform-specific inhibitors can be developed based on the ...
Pyne, Susan +2 more
openaire +4 more sources
Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P
Microbiology Spectrum, 2022 Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host.
Dev K. Ranjit +8 more
doaj +1 more source
Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection [PDF]
Journal of Cardiovascular Pharmacology, 2009 Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset ...
openaire +2 more sources
PLoS ONE, 2013 ObjectiveExperimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu +8 more
doaj +1 more source