Results 1 to 10 of about 30,128 (249)

The Functional Role of Sphingosine Kinase 2 [PDF]

Frontiers in Molecular Biosciences, 2021
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and
Rocio Diaz Escarcega, Louise D. McCullough, Louise D. McCullough, Andrey S. Tsvetkov, Andrey S. Tsvetkov, Andrey S. Tsvetkov   +5 more
doaj   +3 more sources

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [PDF]

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2013
Sphingosine 1-phosphate (S1P) is an important bioactive sphingolipid metabolite that has been implicated in numerous physiological and cellular processes. Not only does S1P play a structural role in cells by defining the components of the plasma membrane, but in the last 20 years it has been implicated in various significant cell signaling pathways and
K Alexa Orr Gandy, Lina M Obeid
exaly   +3 more sources

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis.

PLoS ONE, 2013
ObjectiveExperimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +2 more sources

Transcriptional Regulation of Sphingosine Kinase 1 [PDF]

Cells, 2020
Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways.
Joseph Bonica, Cungui Mao, Lina M. Obeid, Yusuf A. Hannun   +3 more
doaj   +3 more sources

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy [PDF]

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +2 more sources

Drugging Sphingosine Kinases [PDF]

ACS Chemical Biology, 2014
The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2. SphK is a key regulator of S1P and the S1P:Sph/ceramide ratio.
Santos, Webster L., Lynch, Kevin R.
openaire   +2 more sources

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
doaj   +1 more source

Sphingosine Kinases as Druggable Targets [PDF]

, 2018
There is substantial evidence that the enzymes, sphingosine kinase 1 and 2, which catalyse the formation of the bioactive lipid sphingosine 1-phosphate, are involved in pathophysiological processes. In this chapter, we appraise the evidence that both enzymes are druggable and describe how isoform-specific inhibitors can be developed based on the ...
Pyne, Susan, Adams, David R., Pyne, Nigel J.   +2 more
openaire   +4 more sources

Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P

Microbiology Spectrum, 2022
Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host.
Dev K. Ranjit, Zachary D. Moye, Fernanda G. Rocha, Gregory Ottenberg, Frank C. Nichols, Hey-Min Kim, Alejandro R. Walker, Frank C. Gibson, Mary E. Davey   +8 more
doaj   +1 more source

Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection [PDF]

Journal of Cardiovascular Pharmacology, 2009
Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset ...
openaire   +2 more sources