Results 11 to 20 of about 30,128 (249)

Cellular signalling by sphingosine kinase and sphingosine 1‐phosphate [PDF]

IUBMB Life, 2006
AbstractSphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1‐phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular maturation. The last few years have seen a number of significant advances in understanding of the
Leclercq, T., Pitson, S.
openaire   +4 more sources

Sphingosine kinase 1 as an anticancer therapeutic target

Drug Design, Development and Therapy, 2015
Ying Gao,1,* Fei Gao,2,* Kan Chen,3,* Mei-li Tian,1 Dong-li Zhao1 1Department of Radiotherapy Oncology, First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Neurology, First Affiliated Hospital of Xi’an Medical University ...
Gao Y, Gao F, Chen K, Tian ML, Zhao DL
doaj   +1 more source

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]

, 2012
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe, Fabbro, Doriano, Doriano Fabbro, Huwiler Andrea, Zangemeister-Wittke Uwe, Huwiler, Andrea, Uwe Zangemeister-Wittke, Kotelevets Nataliya, Nataliya Kotelevets (156133), Kotelevets, Nataliya, Nataliya Kotelevets, Andrea Huwiler, Doriano Fabbro (156139), Andrea Huwiler (156145), Uwe Zangemeister-Wittke (156150), Fabbro Doriano   +15 more
core   +1 more source

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Pfeilschrifter, Josef, Koch, Alexander, Alexander Koch, Josef Pfeilschifter, Pfeilschifter, Josef, Huwiler, Andrea, Andrea Huwiler   +6 more
core   +1 more source

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]

, 2011
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Sabbadini Roger A., Satish Kalari, Nigel J. Pyne (356726), Garcia, Joe G N, Pyne Nigel J., Nigel J Pyne, Susan Pyne (356727), Natarajan Viswanathan, Pyne, S, Zhao, Y, Roger A. Sabbadini (7924547), Berdyshev, Evgeny V, Garcia, JGN, Roger A Sabbadini, Peter Usatyuk (356723), Garcia Joe G. N., Satish Kalari (307462), Nigel J. Pyne, Berdyshev Evgeny V., Natarajan, V, Usatyuk, Peter, Yutong Zhao, Kalari Satish, Garcia, Joe G.N., Usatyuk, P, Kalari, S, Sabbadini, RA, Viswanathan Natarajan, Roger A. Sabbadini, Joe G. N. Garcia (7923365), Evgeny V Berdyshev, Zhao Yutong, Joe G N Garcia, Sabbadini, Roger A, Pyne, Nigel J, Pyne, NJ, Pyne Susan, Yutong Zhao (356724), Evgeny V. Berdyshev (7924544), Irina Gorshkova (356721), Gorshkova, Irina, Usatyuk Peter, Kalari, Satish, Pyne, Susan, Irina Gorshkova, Gorshkova, I, Evgeny V. Berdyshev, Joe G. N. Garcia, Gorshkova Irina, Peter Usatyuk, Natarajan, Viswanathan, Berdyshev, EV, Susan Pyne, Zhao, Yutong, Viswanathan Natarajan (307479)   +54 more
core   +1 more source

A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids

Metabolites, 2020
The number, position, and configuration of double bonds in lipids affect membrane fluidity and the recruitment of signaling proteins. Studies on mammalian sphingolipids have focused on those with a saturated sphinganine or mono-unsaturated sphingosine ...
Timothy Andrew Couttas, Yepy Hardi Rustam, Huitong Song, Yanfei Qi, Jonathan David Teo, Jinbiao Chen, Gavin Edmund Reid, Anthony Simon Don   +7 more
doaj   +1 more source

Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine

Marine Drugs, 2015
A series of carbocyclic analogues of naturally-occurring marine sphingolipid pachastrissamine were prepared and biologically evaluated. The analogues were efficiently synthesized via a tandem enyne/diene-ene metathesis reaction as a key step.
Yongseok Kwon, Jayoung Song, Hoon Bae, Woo-Jung Kim, Joo-Youn Lee, Geun-Hee Han, Sang Kook Lee, Sanghee Kim   +7 more
doaj   +1 more source

An oncogenic role of sphingosine kinase [PDF]

Current Biology, 2000
Sphingosine kinase (SphK) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). S1P/SphK has been implicated as a signalling pathway to regulate diverse cellular functions [1-3], including cell growth, proliferation and survival [4-8].
Xia, P., Gamble, J., Wang, L., Pitson, S., Moretti, P., Wattenberg, B., D'Andrea, R., Vadas, M.   +7 more
openaire   +3 more sources

Bile acids as global regulators of hepatic nutrient metabolism

Liver Research, 2017
Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon, Kazuaki Takabe, Mikhail Dozmorov, Masayuki Nagahashi, Huiping Zhou   +4 more
doaj   +1 more source

Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis

Molecular Medicine, 2022
Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao, Wenying Zeng, Pengcheng Zhang, Yuan Zhou, Qiangqiang Fang   +4 more
doaj   +1 more source