Results 11 to 20 of about 526,512 (229)
Cellular signalling by sphingosine kinase and sphingosine 1‐phosphate [PDF]
IUBMB Life, 2006 AbstractSphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1‐phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular maturation. The last few years have seen a number of significant advances in understanding of the
Leclercq, T., Pitson, S.
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Sphingosine kinase 1 as an anticancer therapeutic target
Drug Design, Development and Therapy, 2015 Ying Gao,1,* Fei Gao,2,* Kan Chen,3,* Mei-li Tian,1 Dong-li Zhao1 1Department of Radiotherapy Oncology, First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Neurology, First Affiliated Hospital of Xi’an Medical University ...
Gao Y, Gao F, Chen K, Tian ML, Zhao DL
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Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]
, 2011 Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Gorshkova, Irina +9 more
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Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]
, 2012 Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe +15 more
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Sphingosine 1-phosphate in renal diseases [PDF]
, 2013 Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Pfeilschrifter, Josef +6 more
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Acta Dermato-Venereologica, 2019 Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis.
Sun-Hye Shin +8 more
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Frontiers in Genetics, 2017 Sphingolipid metabolism is important to balance the abundance of bioactive lipid molecules involved in cell signaling, neuronal function, and survival. Specifically, the sphingolipid sphingosine mediates cell death signaling, whereas its phosphorylated ...
Jason P. Chan +6 more
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Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis
Molecular Medicine, 2022 Background Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao +4 more
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Frontiers in Molecular Biosciences, 2021 BackgroundTriple-negative breast cancer (TNBC) features a poor prognosis, which is partially attributed to its high metastatic rate. However, there is no effective target for systemic TNBC therapy due to the absence of estrogen, progesterone, and human ...
Weiwei Shi +12 more
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Identification of sphingosine 1-phosphate level and MAPK/ERK signaling in pancreatic β cells [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose Sphingosine kinase is a lipid kinase that phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). S1P regulates pancreatic islet β-cell endoplasmic reticulum stress and proliferation.
Ji Hyun Park +3 more
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