Results 21 to 30 of about 30,128 (249)
Sphingosine kinase and sphingosine 1-phosphate in asthma
Bioscience Reports, 2010 Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai +2 more
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Acta Dermato-Venereologica, 2019 Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis.
Sun-Hye Shin +8 more
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Frontiers in Genetics, 2017 Sphingolipid metabolism is important to balance the abundance of bioactive lipid molecules involved in cell signaling, neuronal function, and survival. Specifically, the sphingolipid sphingosine mediates cell death signaling, whereas its phosphorylated ...
Jason P. Chan +6 more
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Frontiers in Molecular Biosciences, 2021 BackgroundTriple-negative breast cancer (TNBC) features a poor prognosis, which is partially attributed to its high metastatic rate. However, there is no effective target for systemic TNBC therapy due to the absence of estrogen, progesterone, and human ...
Weiwei Shi +12 more
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Identification of sphingosine 1-phosphate level and MAPK/ERK signaling in pancreatic β cells [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose Sphingosine kinase is a lipid kinase that phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). S1P regulates pancreatic islet β-cell endoplasmic reticulum stress and proliferation.
Ji Hyun Park +3 more
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Timothy, Rohrbach +2 more
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A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation [PDF]
, 2010 Sphingosine kinase 1 (SK1) is a key enzyme in the generation of sphingosine 1-phosphate (S1P) which critically regulates a variety of important cell responses such as proliferation and migration.
Xin, Cuiyan +3 more
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Journal of Chemical Research, 2022 Sphingosine kinase is a lipid kinase that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. Sphingosine-1-phosphate is a bioactive lipid that regulates biological processes. The overexpression of sphingosine kinases is related to a
Tiandi Ding +8 more
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Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]
, 2010 <b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Kane, K.A. +6 more
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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [PDF]
Advances in Biological Regulation, 2016 Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses.
Pyne, Nigel J. +8 more
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