Sphingosine 1-Phosphate in Renal Diseases [PDF]
Cellular Physiology and Biochemistry, 2013 Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Alexander Koch +2 more
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Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. [PDF]
PLoS ONE, 2011 Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Reza Soleimani +2 more
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Sphingosine 1-Phosphate and Atherosclerosis
Journal of Atherosclerosis and Thrombosis, 2017 Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is distributed to HDL, followed by albumin. Since S1P and HDL share several bioactivities, S1P is believed to be responsible for the pleiotropic effects of HDL.
Makoto Kurano, Yutaka Yatomi
semanticscholar +5 more sources
Sphingolipids as Emerging Mediators in Retina Degeneration [PDF]
Frontiers in Cellular Neuroscience, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
M. Victoria Simón +3 more
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Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice [PDF]
Journal of International Medical ResearchObjective This study aimed to explore the effect of sphingosine-1-phosphate on vascular homeostasis in the myocardium of diabetic mice. Methods Bioinformatics analyses were performed to analyze the targets and function of sphingosine-1-phosphate in ...
Guozhu Jin +4 more
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The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy [PDF]
Epilepsia OpenEpilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang +4 more
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Sphingosine 1-phosphate and cancer [PDF]
Nature Reviews Cancer, 2010 There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival.
Nigel J Pyne, Susan Pyne
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Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate [PDF]
iScienceSummary: Benign prostatic hyperplasia (BPH) is a common condition in aging males, but its underlying pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) play important roles in various diseases, while less studied in ...
Daoquan Liu +12 more
doaj +2 more sources
Small EVs From Adipose‐Derived MSCs Modulate Epidermal Barrier and Inflammation Via Sphingosine‐1‐Phosphate Signaling Pathway [PDF]
Journal of Extracellular VesiclesEpidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following ...
Kyong‐Oh Shin +15 more
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Sphingosine-1-phosphate in the regulation of diabetes mellitus: a scientometric study to an in‐depth review [PDF]
Frontiers in EndocrinologyDiabetes is a significant global health issue, causing extensive morbidity and mortality, and represents a serious threat to human health. Recently, the bioactive lipid molecule Sphingosine-1-Phosphate has garnered considerable attention in the field of ...
Jieying Li +7 more
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