Frontiers in Molecular Biosciences, 2021 Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii +7 more
doaj +1 more source
Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma [PDF]
, 2023 Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes.
Laila Parvanta +44 more
core +1 more source
Bile acids as global regulators of hepatic nutrient metabolism
Liver Research, 2017 Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon +4 more
doaj +1 more source
Increased sphingosine-1-phosphate serum concentrations in subjects with periodontitis: a matter of inflammation [PDF]
, 2021 Purpose: Periodontitis is an inflammatory disease of the oral cavity with an alarmingly high prevalence within the adult population. The signaling lipid sphingosine-1-phosphate (S1P) plays a crucial role in inflammatory and immunomodulatory responses. In
Rauch, Bernhard H. +13 more
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Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]
, 2010 <b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Kane, K.A. +6 more
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Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.
Journal of Lipid Research, 1994 The syntheses of D-erythro-sphingosine-1-phosphate and DL-erythro-sphinganine-1-phosphate are described starting from the commercially available D-erythro-sphingosine and DL-erythro-sphinganine.
A Boumendjel, S P Miller
doaj +1 more source
FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke [PDF]
, 2013 Background: The Sphingosine-1-phosphate (S1P) signaling pathway is known to influence pathophysiological processes within the brain and the synthetic S1P analog FTY720 has been shown to provide neuroprotection in experimental models of acute stroke ...
Michel Mittelbronn +35 more
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Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis
Indian Journal of Ophthalmology, 2012 Background: Apoptosis is a programmed cell death in multicellular organisms, found in a wide variety of conditions, including inflammatory process, everywhere in the body, including the cornea and conjunctiva. Aim: To evaluate the effect of a new topical
Pierre Fournie +5 more
doaj +1 more source
Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury [PDF]
, 2010 HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
Bodo Levkau +25 more
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Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases [PDF]
, 2014 Chronic kidney diseases including glomerulonephritis are often accompanied by acute or chronic inflammation that leads to an increase in extracellular matrix (ECM) production and subsequent glomerulosclerosis.
Stephanie Schwalm +5 more
core +1 more source