Results 21 to 30 of about 327,382 (312)

Correction to: Associations of sphingosine‑1‑phosphate with soluble P‑selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Gloyer NO, Moritz E, Schwieren L, Meyer U, Thomalla G, Daum G, Magnus T, Böger R, Choe CU, Rauch BH, Schwedhelm E.   +10 more
europepmc   +3 more sources

Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Nature Communications, 2022
Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors (GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P).
Shian Liu, N. Paknejad, Lan Zhu, Y. Kihara, Manisha Ray, J. Chun, Wei Liu, R. Hite, Xin-Yun Huang   +8 more
semanticscholar   +1 more source

Structural insights into sphingosine-1-phosphate receptor activation

bioRxiv, 2022
As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role in immune and vascular systems. There are five S1P receptors, designated as S1PR1-5, encoded in the human genome, and their activities are governed by endogenous
Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Q. Xiao, Hongli Hu, Lizhe Zhu, Sheng Wang, R. Ren   +8 more
semanticscholar   +1 more source

Sphingosine 1-phosphate signalling [PDF]

Development, 2014
Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival.
Karen, Mendelson, Todd, Evans, Timothy, Hla   +2 more
openaire   +2 more sources

The role of sphingosine-1-phosphate in bone remodeling and osteoporosis

Bone Research, 2022
Osteoporosis is a systemic bone disease that affects more than 200 million people worldwide and is caused by the disruption of the equilibrium between osteoclastic bone resorption and osteoblastic bone formation.
Justus M. Grewe, Paul-Richard Knapstein, Antonia Donat, Shan Jiang, Daniel J. Smit, Weixin Xie, J. Keller   +6 more
semanticscholar   +1 more source

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

ESC Heart Failure, 2023
Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau   +16 more
doaj   +1 more source

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer

Discover Oncology, 2021
Sphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (
Guangmeng Xu, Zecheng Yang, Yamin Sun, Hongmei Dong, Jingru Ma   +4 more
doaj   +1 more source

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis

Cells, 2023
Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils.
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo   +2 more
doaj   +1 more source

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency [PDF]

Journal of Clinical Investigation, 2017
Connolly, Anne M, Cooper, Megan A, Dharnidharka, Vikas R, et al,, Willing, Marcia C   +4 more
core   +3 more sources

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives

Cells, 2020
Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena.
Alexandra Lucaciu, Robert Brunkhorst, Josef M. Pfeilschifter, Waltraud Pfeilschifter, Julien Subburayalu   +4 more
doaj   +1 more source