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Sphingosine 1-phosphate receptor 2 in keratinocytes plays a key role in reducing inflammation in psoriasis [PDF]
Frontiers in ImmunologyBackgroundPsoriasis is an inflammatory skin condition where immune cells play a significant role. The importance of the cross-talk between keratinocytes and immune cells in the pathogenesis of psoriasis has recently been reaffirmed.
Kana Masuda-Kuroki +3 more
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Cells, 2023 Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils.
Kana Masuda-Kuroki +2 more
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Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells
Molecules, 2017 The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P1-S1P5. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system
Nigel J. Pyne, Susan Pyne
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Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5 [PDF]
Nature CommunicationsSphingosine-1-phosphate (S1P) is a crucial sphingolipid mediator in vasculature and neovascular eye diseases by controlling angiogenesis, inflammation and fibrosis.
Xin Qian +16 more
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Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. [PDF]
PLoS ONE, 2011 Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Reza Soleimani +2 more
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ESC Heart Failure, 2023 Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin +16 more
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Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
Biomolecules, 2023 Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in regulating cardiovascular functions in physiological and pathological conditions by binding and activating the three G protein-coupled receptors (S1PR1, S1PR2, and S1PR3 ...
Na Wang +3 more
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Does Siponimod Exert Direct Effects in the Central Nervous System?
Cells, 2020 The modulation of the sphingosine 1-phosphate receptor is an approved treatment for relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes in lymph nodes.
Markus Kipp
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Cells, 2020 Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena.
Alexandra Lucaciu +4 more
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Bile acids as global regulators of hepatic nutrient metabolism
Liver Research, 2017 Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon +4 more
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