Results 31 to 40 of about 327,382 (312)
HYPERTENSION, 2021 Supplemental Digital Content is available in the text. Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is a fundamental pathogenic process associated with malplacentation and the development of preeclampsia ...
Jiujiang Liao +19 more
semanticscholar +1 more source
Regulation of Sphingosine-1-phosphate Lyase Gene Expression by Members of the GATA Family of Transcription Factors [PDF]
, 2005 Sphingosine-1-phosphate is a bioactive sphingolipid that regulates proliferation, differentiation, migration, and apoptosis. Sphingosine-1-phosphate is irreversibly degraded by the highly conserved enzyme sphingosine-1-phosphate lyase.
Fyrst, Henrik +5 more
core +1 more source
Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology.
Pharmacological Research, 2020 Sphingosine-1-phosphate (S1P) is a signaling lipid, synthetized by sphingosine kinases (SPHK1 and SPHK2), that affects cardiovascular function in various ways.
E. Józefczuk +4 more
semanticscholar +1 more source
Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]
, 2003 Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik +3 more
core +1 more source
Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
Biomolecules, 2023 Sphingosine-1-phosphate (S1P) is an important sphingolipid molecule involved in regulating cardiovascular functions in physiological and pathological conditions by binding and activating the three G protein-coupled receptors (S1PR1, S1PR2, and S1PR3 ...
Na Wang +3 more
doaj +1 more source
Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. [PDF]
, 2015 The colonial ascidian Botryllus schlosseri continuously regenerates entire bodies in an asexual budding process. The germ line of the newly developing bodies is derived from migrating germ cell precursors, but the signals governing this homing process ...
Bui, Connor +4 more
core +1 more source
Sphingosine 1-phosphate chemical biology [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2008 A dozen years ago, the term 'S1P' (sphingosine 1-phosphate) was not in the lexicons of scientific literature databases. By early 2008, this query term retrieved well over 1000 citations from PubMed - about 225 of these appeared in 2007. Indeed, S1P is arguably the most heavily studied lipid molecule at present.
Kevin R, Lynch, Timothy L, Macdonald
openaire +2 more sources
Drugs, 2020 Lysophospholipids are a class of bioactive lipid molecules that produce their effects through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is perhaps the most studied lysophospholipid and has a role in a wide range of ...
J. Chun, G. Giovannoni, S. Hunter
semanticscholar +1 more source
Endothelial sphingosine 1-phosphate receptors promote vascular normalization and antitumor therapy
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Tumor progression is dependent on angiogenesis, which supplies nutrients and enables gas exchange and metastatic dissemination. However, tumor vessels are dysfunctional and immature, which hinders the effectiveness of various therapeutics ...
Andreane Cartier +3 more
semanticscholar +1 more source
Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]
, 2017 Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia +4 more
core +2 more sources