Results 31 to 40 of about 37,566 (200)
Sphingolipids as Emerging Mediators in Retina Degeneration
Frontiers in Cellular Neuroscience, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
M. Victoria Simón +3 more
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Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks
Cells, 2020 As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer ...
Laura Riboni +5 more
doaj +1 more source
The Golgi-localized sphingosine-1-phosphate phosphatase is indispensable for Leishmania major
Scientific Reports, 2022 Sphingosine-1-phosphate phosphatase (SPP) catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) into sphingosine, the reverse reaction of sphingosine kinase.
Brian Okundaye +3 more
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Cells, 2022 The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson +9 more
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The Anti-Infectious Role of Sphingosine in Microbial Diseases
Cells, 2021 Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions.
Yuqing Wu +3 more
doaj +1 more source
Sphingosine 1-phosphate in coagulation and inflammation [PDF]
Seminars in Immunopathology, 2011 Sphingosine 1-phosphate (S1P) is a lipid mediator produced from sphingomyelin by the sequential enzymatic actions of sphingomyelinase, ceramidase, and sphingosine kinase. Five subtypes of cell surface G-protein-coupled receptors, S1P(1-5), mediate the actions of S1P in various organs systems, most notably cardiovascular, immune, and central nervous ...
Hideru, Obinata, Timothy, Hla
openaire +2 more sources
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
Journal of Lipid Research, 2009 The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka +2 more
doaj +1 more source
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants
Annals of Clinical and Translational Neurology, EarlyView.Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold +12 more
wiley +1 more source
Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases
Liver Research, 2019 The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
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Effects of sphingolipid metabolism disorders on endothelial cells
Lipids in Health and Disease, 2022 Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai +4 more
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