Results 31 to 40 of about 30,263,703 (145)

Sphingolipids as Emerging Mediators in Retina Degeneration

Frontiers in Cellular Neuroscience, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
M. Victoria Simón, Facundo H. Prado Spalm, Marcela S. Vera, Nora P. Rotstein   +3 more
doaj   +1 more source

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Cells, 2020
As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer ...
Laura Riboni, Loubna Abdel Hadi, Stefania Elena Navone, Laura Guarnaccia, Rolando Campanella, Giovanni Marfia   +5 more
doaj   +1 more source

The Golgi-localized sphingosine-1-phosphate phosphatase is indispensable for Leishmania major

Scientific Reports, 2022
Sphingosine-1-phosphate phosphatase (SPP) catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) into sphingosine, the reverse reaction of sphingosine kinase.
Brian Okundaye, Neha Biyani, Samrat Moitra, Kai Zhang   +3 more
doaj   +1 more source

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Cells, 2022
The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal   +9 more
doaj   +1 more source

Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection [PDF]

, 2011
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the ...
Hacking, Damian
core   +1 more source

The Anti-Infectious Role of Sphingosine in Microbial Diseases

Cells, 2021
Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions.
Yuqing Wu, Yongjie Liu, Erich Gulbins, Heike Grassmé   +3 more
doaj   +1 more source

Functional Characterization of a Higher Plant Sphingolipid Δ4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis [PDF]

, 2008
The role of Δ4-unsaturated sphingolipid long-chain bases such as sphingosine was investigated in Arabidopsis (Arabidopsis thaliana). Identification and functional characterization of the sole Arabidopsis ortholog of the sphingolipid Δ4-desaturase was ...
Warnecke, D., Sperling, Petra, Haslam, Richard P., Mugford, S., Napier, Johnathan A., Sperling, P., Sarah Mugford, Albrecht, S., Johnathan A. Napier, Petra Sperling, Richard P. Haslam, Simone Zäuner, Michaelson, L. V., Desikan, R., Haslam, R. P., Sandra Albrecht, Radhika Desikan, Dirk Warnecke, Albrecht, Sandra, Markham, J. E., Heinz, E., Warnecke, Dirk, E. Heinz, Desikan, Radhika, Michaelson, Louise V., Louise V. Michaelson, Markham, Jennifer E., Zauner, S., Zäuner, Simone, Napier, J. A., Mugford, Sarah, Jennifer E. Markham   +31 more
core   +1 more source

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

Journal of Lipid Research, 2009
The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka, Sheldon Milstien, Sarah Spiegel   +2 more
doaj   +1 more source

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +1 more source

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases

Liver Research, 2019
The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
doaj   +1 more source