Results 51 to 60 of about 30,263,703 (145)
Role of sphingosine-1-phosphate receptor 1 and downstream heme oxygenase-1 induction in alternative macrophage activation induced by apoptotic cells [PDF]
, 2010 Macrophages show a remarkable functional plasticity, which enables them to change their phenotype in response to environmental signals. They are key players during infection by initiating inflammation through the release of proinflammatory mediators ...
Weis, Nicole
core
Does Siponimod Exert Direct Effects in the Central Nervous System?
Cells, 2020 The modulation of the sphingosine 1-phosphate receptor is an approved treatment for relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes in lymph nodes.
Markus Kipp
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, 2009 Sphingosine 1-phosphate (S1P) is a multifunctional phospholipid which acts through a specific family of G protein-coupled receptors. Platelet/ endothelial cell adhesion molecule-1 (PECAM-1) form trans-homophilic binding at lateral cell border.
HUANG, YU-TING;CHEN, SHEE-UAN;CHOU, CHIA-HUNG;LEE, HSIN-YU +1 more
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Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate
iScienceSummary: Benign prostatic hyperplasia (BPH) is a common condition in aging males, but its underlying pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) play important roles in various diseases, while less studied in ...
Daoquan Liu +12 more
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Frontiers in Immunology, 2017 Sphingolipid metabolites are emerging as important signaling molecules in allergic diseases specifically asthma. One of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), is involved in cell differentiation, proliferation, survival, migration ...
Rohit Saluja +4 more
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The role of sphingosine 1-phosphate in inflammation and cancer [PDF]
, 2014 The enzymes that catalyze formation of the bioactive sphingolipid, sphingosine 1-phosphate, sphingosine kinase 1 and 2, are predictive markers in inflammatory diseases and cancer as evidenced by data from patients, knockout mice and the use of available ...
Pyne, Nigel J +3 more
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Frontiers in EndocrinologyDiabetes is a significant global health issue, causing extensive morbidity and mortality, and represents a serious threat to human health. Recently, the bioactive lipid molecule Sphingosine-1-Phosphate has garnered considerable attention in the field of ...
Jieying Li +7 more
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Cancer Cell InternationalPancreatic cancer is known to be the most lethal cancer. Fewer new treatments are being developed for pancreatic cancer as compared to other cancers. The bioactive lipid S1P, which is mainly regulated by sphingosine kinase 1 (SK1) and sphingosine kinase ...
Khem Raj Limbu +6 more
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PLoS ONE, 2016 Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality.
Aneta Dobierzewska +7 more
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The Role of Sphingolipid Metabolism in Pregnancy-Associated Breast Cancer After Chemotherapy
BiomedicinesBackground: The aim of our study was to determine the role of sphingolipids, which control proliferation and apoptosis, in the placenta of pregnant women with pregnancy-associated breast cancer (PABC) after chemotherapy compared with healthy patients ...
Victor Blokhin +11 more
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