Results 41 to 50 of about 30,263,703 (145)

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
doaj   +1 more source

A Saudi child with Sphingosine Phosphate Lyase insufficiency syndrome

Journal of Biochemical and Clinical Genetics, 2021
Background: Sphingosine Phosphate Lyase Insufficiency Syndrome SPLIS is a recently described condition, which is associated with loss of function mutations in SGPL1, encoding sphingosine-1-phosphate lyase.
Lamya Ahmad Faisal Alrayes, Mohammed Alotaibi, Afaf Alsagheir   +2 more
doaj   +1 more source

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Cell Reports, 2016
Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis; however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in endocytic trafficking has not been established. Here, we demonstrate that
Megan M. Young, Yoshinori Takahashi, Todd E. Fox, Jong K. Yun, Mark Kester, Hong-Gang Wang   +5 more
doaj   +1 more source

Rôle de la sphingosine 1-phosphate dans les interactions mélanome-stroma [PDF]

, 2012
Le mélanome métastatique demeure un cancer au sombre pronostic, et aucune des thérapies conventionnelles n'a pu apporter de bénéfice sur la survie globale.
Albinet, Virginie
core  

Roles of sphingosine 1-phosphate on tumorigenesis

, 2011
[[abstract]]Roles of sphingosine 1-phosphate on ...
黃元勵;Huang, Yuan-Li, Yuan-Li Huang
core   +1 more source

Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity.

PLoS ONE, 2019
Systemic lupus erythematous (SLE) is a chronic multi-organ autoimmune disease. Genetic and environmental factors contribute to disease onset and severity.
Samar M Hammad, Jasmyn R Hardin, Dulaney A Wilson, Waleed O Twal, Paul J Nietert, James C Oates   +5 more
doaj   +1 more source

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*

Journal of Lipid Research, 2009
Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in ...
Hitoshi Ikeda, Naoko Watanabe, Isao Ishii, Tatsuo Shimosawa, Yukio Kume, Tomoaki Tomiya, Yukiko Inoue, Takako Nishikawa, Natsuko Ohtomo, Yasushi Tanoue, Satoko Iitsuka, Ryoto Fujita, Masao Omata, Jerold Chun, Yutaka Yatomi   +14 more
doaj   +1 more source

Small EVs From Adipose‐Derived MSCs Modulate Epidermal Barrier and Inflammation Via Sphingosine‐1‐Phosphate Signaling Pathway

Journal of Extracellular Vesicles
Epidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following ...
Kyong‐Oh Shin, Jun Ho Lee, Seungwoo Chae, Karin Goto, Hahyun An, Joan S. Wakefield, Dae Hyun Ha, Healim Lee, Kyojin Lee, Hyunju Lee, Ella Shin, Min Ji Kang, Sinhee Lee, Yoshikazu Uchida, Byong Seung Cho, Kyungho Park   +15 more
doaj   +1 more source

Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator [PDF]

, 2011
Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems.
Bianca Hegen, van Echten-Deckert, Gerhild, Huwiler, Andrea, Dagmar Meyer zu Heringdorf, Sandra Labocha, Michael ter Braak, Heringdorf, Dagmar Meyer Zu, Gerhild van Echten-Deckert, Labocha, Sandra, Ferreirós, Nerea, Meyer Zu Heringdorf, Dagmar, Ter Braak, Michael, Josef Pfeilschifter, Pfeilschifter, Josef, Nerea Ferreirós, Ralf Frederik Claas, Hegen, Bianca, Andrea Huwiler, Claas, Ralf Frederik   +18 more
core   +1 more source

Mitochondrial sphingosine-1-phosphate lyase is essential for phosphatidylethanolamine synthesis and survival of Trypanosoma brucei [PDF]

, 2020
Sphingosine-1-phosphate is a signaling molecule involved in the control of cell migration, differentiation, survival and other physiological processes. This sphingolipid metabolite can be degraded by the action of sphingosine-1-phosphate lyase (SPL) to ...
Rauch, Monika, Bütikofer, Peter, Stumpe, Michael, Dawoody Nejad, Ladan, Hemphill, Andrew, Schneiter, Roger, Serricchio, Mauro   +6 more
core   +2 more sources