Results 41 to 50 of about 21,457,228 (260)

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Cells, 2020
As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer ...
Laura Riboni, Loubna Abdel Hadi, Stefania Elena Navone, Laura Guarnaccia, Rolando Campanella, Giovanni Marfia   +5 more
doaj   +1 more source

The Golgi-localized sphingosine-1-phosphate phosphatase is indispensable for Leishmania major

Scientific Reports, 2022
Sphingosine-1-phosphate phosphatase (SPP) catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) into sphingosine, the reverse reaction of sphingosine kinase.
Brian Okundaye, Neha Biyani, Samrat Moitra, Kai Zhang   +3 more
doaj   +1 more source

Sphingolipids as Emerging Mediators in Retina Degeneration

Frontiers in Cellular Neuroscience, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
M. Victoria Simón, Facundo H. Prado Spalm, Marcela S. Vera, Nora P. Rotstein   +3 more
doaj   +1 more source

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model

Cells, 2022
The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal   +9 more
doaj   +1 more source

Sphingosine 1-phosphate in coagulation and inflammation [PDF]

Seminars in Immunopathology, 2011
Sphingosine 1-phosphate (S1P) is a lipid mediator produced from sphingomyelin by the sequential enzymatic actions of sphingomyelinase, ceramidase, and sphingosine kinase. Five subtypes of cell surface G-protein-coupled receptors, S1P(1-5), mediate the actions of S1P in various organs systems, most notably cardiovascular, immune, and central nervous ...
Hideru, Obinata, Timothy, Hla
openaire   +2 more sources

Increased sphingosine-1-phosphate serum concentrations in subjects with periodontitis: a matter of inflammation [PDF]

, 2021
Purpose: Periodontitis is an inflammatory disease of the oral cavity with an alarmingly high prevalence within the adult population. The signaling lipid sphingosine-1-phosphate (S1P) plays a crucial role in inflammatory and immunomodulatory responses. In
Rauch, Bernhard H., Meisel, Peter, Völzke, Henry, Negnal, Josefine, Felix, Stephan B., Dörr, Marcus, Jedlitschky, Gabriele, Schwedhelm, Edzard, Daum, Günter, Tzvetkov, Mladen V., Kocher, Thomas, Nauck, Matthias, Moritz, Eileen, Holtfreter, Birte   +13 more
core  

The Anti-Infectious Role of Sphingosine in Microbial Diseases

Cells, 2021
Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions.
Yuqing Wu, Yongjie Liu, Erich Gulbins, Heike Grassmé   +3 more
doaj   +1 more source

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Radeke, Heinfried H., Japtok, Lukasz, Heinfried H Radeke, Kleuser, Burkhard, Jeong, Se Kyoo, Wolfgang Bäumer, Burkhard Kleuser, Katrin Schaper, Heinfried H. Radeke, Schaper, Katrin, Lukasz Japtok, Bäumer, Wolfgang, Se Kyoo Jeong   +13 more
core   +1 more source

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

Journal of Lipid Research, 2009
The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka, Sheldon Milstien, Sarah Spiegel   +2 more
doaj   +1 more source

A Saudi child with Sphingosine Phosphate Lyase insufficiency syndrome

Journal of Biochemical and Clinical Genetics, 2021
Background: Sphingosine Phosphate Lyase Insufficiency Syndrome SPLIS is a recently described condition, which is associated with loss of function mutations in SGPL1, encoding sphingosine-1-phosphate lyase.
Lamya Ahmad Faisal Alrayes, Mohammed Alotaibi, Afaf Alsagheir   +2 more
doaj   +1 more source