Results 1 to 10 of about 26,969 (190)
Transcriptional Regulation of Sphingosine Kinase 1 [PDF]
Cells, 2020 Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways.
Joseph Bonica +3 more
doaj +5 more sources
Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model [PDF]
Cells, 2022 The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson +9 more
doaj +2 more sources
Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer [PDF]
International Journal of Molecular Sciences, 2017 Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by growth factors, cytokines, and carcinogens, leading to the increase of S1P production.
Wancai Yang, Yonghua Bao, Yang Wancai
exaly +3 more sources
Sphingolipid Expression During Corneal Wound Healing in a Sphingosine Kinase 1 Knockout Model [PDF]
CellsCorneal scarring is a result of unregulated fibrotic processes in wound healing, which causes visual impairment. Bioactive sphingolipids (SPLs) are known to modulate physiological processes that are central to wound healing.
Sandip K. Basu +10 more
doaj +2 more sources
Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH [PDF]
Molecular Metabolism, 2022 Objective: Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of this dimorphism is unclear.
David Montefusco +10 more
doaj +2 more sources
PLoS ONE, 2016 Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality.
Aneta Dobierzewska +7 more
doaj +6 more sources
The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension [PDF]
American Journal of Respiratory and Critical Care Medicine, 2014 Abstract Rationale Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of the bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that promotes cell proliferation, migration, and angiogenesis ...
Haiyang Tang +2 more
exaly +3 more sources
Epilepsia OpenEpilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang +4 more
doaj +3 more sources
EMBO Molecular Medicine, 2012 Mechanisms by which cancer cells communicate with the host organism to regulate lung colonization/metastasis are unclear. We show that this communication occurs via sphingosine 1‐phosphate (S1P) generated systemically by sphingosine kinase 1 (SK1 ...
Suriyan Ponnusamy +8 more
doaj +2 more sources
A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids
Metabolites, 2020 The number, position, and configuration of double bonds in lipids affect membrane fluidity and the recruitment of signaling proteins. Studies on mammalian sphingolipids have focused on those with a saturated sphinganine or mono-unsaturated sphingosine ...
Timothy Andrew Couttas +7 more
doaj +3 more sources