Results 1 to 10 of about 27,846 (115)

Ablation of Sphingosine Kinase 1 Protects Cornea from Neovascularization in a Mouse Corneal Injury Model [PDF]

Cells, 2022
The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson, Sandip K. Basu, Megan A. Stiles, Amanda Prislovsky, Richard C. Grambergs, Sarah E. Nicholas, Dimitrios Karamichos, Jeremy C. Allegood, Richard L. Proia, Nawajes Mandal   +9 more
doaj   +2 more sources

Transcriptional Regulation of Sphingosine Kinase 1 [PDF]

Cells, 2020
Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways.
Joseph Bonica, Cungui Mao, Lina M. Obeid, Yusuf A. Hannun   +3 more
doaj   +2 more sources

Sphingolipid Expression During Corneal Wound Healing in a Sphingosine Kinase 1 Knockout Model [PDF]

Cells
Corneal scarring is a result of unregulated fibrotic processes in wound healing, which causes visual impairment. Bioactive sphingolipids (SPLs) are known to modulate physiological processes that are central to wound healing.
Sandip K. Basu, Steve Mabry, Peter Nsiah, Sarah E. Nicholas, Nataliya Lenchik, Mark Altawil, Chi-Yang Chiu, Daniel J. Stephenson, Charles E. Chalfant, Dimitrios Karamichos, Nawajes Mandal   +10 more
doaj   +2 more sources

Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH [PDF]

Molecular Metabolism, 2022
Objective: Men with non-alcoholic fatty liver disease (NAFLD) are more likely to progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of this dimorphism is unclear.
David Montefusco, Maryam Jamil, Melissa A. Maczis, William Schroeder, Moshe Levi, Suman Ranjit, Jeremy Allegood, Dipankar Bandyopadhyay, Reuben Retnam, Sarah Spiegel, L. Ashley Cowart   +10 more
doaj   +2 more sources

The Functional Role of Sphingosine Kinase 2

Frontiers in Molecular Biosciences, 2021
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and
Rocio Diaz Escarcega, Louise D. McCullough, Louise D. McCullough, Andrey S. Tsvetkov, Andrey S. Tsvetkov, Andrey S. Tsvetkov   +5 more
doaj   +1 more source

Sphingosine Kinase 1 – A Therapeutic Opportunity for Alleviating Liver Fibrosis? [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Jia Ming Nickolas Teo, Guang Sheng Ling
doaj   +2 more sources

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells

Frontiers in Molecular Biosciences, 2021
Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii, Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong, Chee-Onn Leong   +7 more
doaj   +1 more source

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis.

PLoS ONE, 2013
ObjectiveExperimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
doaj   +1 more source

Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice

Acta Dermato-Venereologica, 2019
Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis.
Sun-Hye Shin, Kyung-Ah Cho, Soojung Hahn, Younghay Lee, Yu-He Kim, So-Youn Woo, Kyung-Ha Ryu, Woo-Jae Park, Joo-Won Park   +8 more
doaj   +1 more source