Results 31 to 40 of about 26,969 (190)
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006 Sphingolipids are ubiquitous components of cell membranes and their metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) have important physiological functions, including regulation of cell growth and survival. Cer and Sph are associated with growth arrest and apoptosis.
Hait, Nitai C. +4 more
openaire +2 more sources
Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [PDF]
Advances in Biological Regulation, 2016 Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses.
Pyne, Nigel J. +8 more
openaire +5 more sources
Frontiers in Molecular Biosciences, 2021 BackgroundTriple-negative breast cancer (TNBC) features a poor prognosis, which is partially attributed to its high metastatic rate. However, there is no effective target for systemic TNBC therapy due to the absence of estrogen, progesterone, and human ...
Weiwei Shi +12 more
doaj +1 more source
The Role of Sphingolipids in the Pathogenesis of Psoriasis
Metabolites, 2022 Psoriasis is a complex, chronic, immunologically mediated disease which involves skin and joints. Psoriasis is commonly connected with numerous other diseases such as liver diseases, metabolic syndrome, impaired glucose tolerance, diabetes mellitus ...
Mateusz Matwiejuk +3 more
doaj +1 more source
Functional characterization of human sphingosine kinase‐1 [PDF]
FEBS Letters, 2000 Sphingosine kinase catalyzes the phosphorylation of sphingosine to form sphingosine 1‐phosphate (SPP), a novel lipid mediator with both intra‐ and extracellular functions. Based on sequence identity to murine sphingosine kinase (mSPHK1a), we cloned and characterized the first human sphingosine kinase (hSPHK1). The open reading frame of hSPHK1 encodes a
Nava, Victor E. +8 more
openaire +2 more sources
Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
Frontiers in Pharmacology, 2019 The central nervous system is characterized by a high content of sphingolipids and by a high diversity in terms of different structures. Stage- and cell-specific sphingolipid metabolism and expression are crucial for brain development and maintenance ...
Sara Grassi +6 more
doaj +1 more source
Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients
Walailak Journal of Science and Technology, 2016 The aim of this study was to investigate the expression of S1PR4 in colorectal cancer and its correlation with clinicopathologic characteristics. Paraffin-embedded colorectal cancer samples and matched adjacent normal tissues were collected from 32 ...
Suchittra SAMUHASANEETO +2 more
doaj +1 more source
International Journal of Immunopathology and Pharmacology, 2021 Background: Sphingosine kinase has been identified as playing a central role in the immune cascade, being a common mediator in the cellular response to a variety of signals.
Yuval Ishay +2 more
doaj +1 more source
Aminoacylase 1 is a sphingosine kinase 1‐interacting protein [PDF]
FEBS Letters, 2004 Sphingosine kinase type 1 (SphK1) and its product sphingosine‐1‐phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. In an effort to further understand the regulation of SphK1, we used a yeast two‐hybrid screen to find SphK1‐interacting proteins.
Maceyka, Michael +3 more
openaire +2 more sources
Sphingosine kinase 1 expression enhances colon tumor growth
Journal of Translational Medicine, 2017 Background Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis.
Hideki Furuya +7 more
doaj +1 more source