Results 51 to 60 of about 30,319,267 (183)

FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke [PDF]

, 2013
Background: The Sphingosine-1-phosphate (S1P) signaling pathway is known to influence pathophysiological processes within the brain and the synthetic S1P analog FTY720 has been shown to provide neuroprotection in experimental models of acute stroke ...
Michel Mittelbronn, Alexander Koch (77280), Pia Zeiner (440015), Koch, Alexander, Mirceska, Ana, Ana Mirceska, Zeiner, Pia Susan, Michel Mittelbronn (307400), Alexander Koch, Derouiche, Amin, Helmuth Steinmetz (149409), Pfeilschifter, Josef, Nerea Ferreirós, Josef Pfeilschifter (92946), Kanaan, Nathalie, Amin Derouiche (226736), Mittelbronn, Michel Guy André, Christian Foerch (149410), Pia Zeiner, Ferreirós Bouzas, Nerea, Förch, Christian, Nathalie Kanaan, Waltraud Pfeilschifter, Robert Brunkhorst, Nathalie Kanaan (440013), Brunkhorst, Robert, Waltraud Pfeilschifter (149411), Helmuth Steinmetz, Steinmetz, Helmuth, Christian Foerch, Pfeilschifter, Waltraud, Josef Pfeilschifter, Robert Brunkhorst (405629), Ana Mirceska (149407), Amin Derouiche, Nerea Ferreirós (440014)   +35 more
core   +2 more sources

The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection

iScience, 2021
Summary: Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths.
Gergely Imre, Verena Krähling, Madeleine Eichler, Sandra Trautmann, Nerea Ferreirós, M. Javad Aman, Fatah Kashanchi, Krishnaraj Rajalingam, Stefan Pöhlmann, Stephan Becker, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter   +11 more
doaj   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Rôle de la sphingosine 1-phosphate dans les interactions mélanome-stroma [PDF]

, 2012
Le mélanome métastatique demeure un cancer au sombre pronostic, et aucune des thérapies conventionnelles n'a pu apporter de bénéfice sur la survie globale.
Albinet, Virginie
core  

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

Journal of Lipid Research, 2009
The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka, Sheldon Milstien, Sarah Spiegel   +2 more
doaj   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.

PLoS ONE, 2018
Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies.
Yugesh Kharel, Sayeh Agah, Tao Huang, Anna J Mendelson, Oluwafunmilayo T Eletu, Peter Barkey-Bircann, James Gesualdi, Jeffrey S Smith, Webster L Santos, Kevin R Lynch   +9 more
doaj   +1 more source

An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S]

Journal of Lipid Research, 2018
Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular growth, immune cell trafficking, and inflammation.
Michael J. Pulkoski-Gross, Meredith L. Jenkins, Jean-Philip Truman, Mohamed F. Salama, Christopher J. Clarke, John E. Burke, Yusuf A. Hannun, Lina M. Obeid   +7 more
doaj   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1‐phosphate signalling to regulate tumour metastasis

EMBO Molecular Medicine, 2012
Mechanisms by which cancer cells communicate with the host organism to regulate lung colonization/metastasis are unclear. We show that this communication occurs via sphingosine 1‐phosphate (S1P) generated systemically by sphingosine kinase 1 (SK1 ...
Suriyan Ponnusamy, Shanmugam Panneer Selvam, Shikhar Mehrotra, Toshihiko Kawamori, Ashley J. Snider, Lina M. Obeid, Yuan Shao, Roger Sabbadini, Besim Ogretmen   +8 more
doaj   +1 more source