Results 61 to 70 of about 26,969 (190)
Journal of Chemical Research, 2022 Sphingosine kinase is a lipid kinase that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate. Sphingosine-1-phosphate is a bioactive lipid that regulates biological processes. The overexpression of sphingosine kinases is related to a
Tiandi Ding +8 more
doaj +1 more source
Food Chemistry International, EarlyView.The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi +2 more
wiley +1 more source
The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
iScience, 2021 Summary: Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths.
Gergely Imre +11 more
doaj +1 more source
Grassland Research, EarlyView.Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao +6 more
wiley +1 more source
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
Journal of Lipid Research, 2009 The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka +2 more
doaj +1 more source
Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2015 Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity.
Yugesh, Kharel +6 more
openaire +2 more sources
International Journal of Cancer, EarlyView.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.
PLoS ONE, 2018 Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies.
Yugesh Kharel +9 more
doaj +1 more source
An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S]
Journal of Lipid Research, 2018 Sphingosine kinase 1 (SK1) is required for production of sphingosine-1-phosphate (S1P) and thereby regulates many cellular processes, including cellular growth, immune cell trafficking, and inflammation.
Michael J. Pulkoski-Gross +7 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source