Results 81 to 90 of about 30,319,267 (183)
M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis
Journal of Diabetes Investigation, EarlyView.ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li +5 more
wiley +1 more source
Understanding exosomes in diabetic wound healing
Periodontology 2000, EarlyView.Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad +4 more
wiley +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Drug Development Research, Volume 87, Issue 7, November 2026.ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Chaofu Yue +15 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
Cellular signalling by sphingosine kinase and sphingosine 1-phosphate
, 2006 Sphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1-phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular ...
Pitson, S. +3 more
core +1 more source
Significance of sphingosine kinase 1 expression in feline mammary tumors
BMC Veterinary Research, 2019 Background Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate.
Yi-Chih Chang +5 more
doaj +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.ABSTRACT Background Crohn's disease (CD) is a multifactorial inflammatory bowel disease (IBD) characterized by impaired epithelial barrier integrity, excessive immune hyperactivation, and gut microbiota perturbations. Cumulative evidence supports the role of the intestinal epithelial barrier, immune system and gut microbiota in the progression of CD ...
Qing Lai +3 more
wiley +1 more source
Roles of sphingosine 1-phosphate on tumorigenesis
, 2011 [[abstract]]Roles of sphingosine 1-phosphate on ...
黃元勵;Huang, Yuan-Li, Yuan-Li Huang
core +1 more source
Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.Estradiol (E2) promotes tumor progression in ERα‐low endometrial cancer through the GPER/SphK1/ERK1/2 signaling axis. E2 binding to GPER activates SphK1 and downstream ERK1/2, upregulating Cyclin D1, Cyclin E1, and MMP‐9 to drive cell proliferation, migration, and invasion.
Xiuwen Wang +6 more
wiley +1 more source