Results 101 to 110 of about 30,319,267 (183)

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Role of Extracellular Vesicles in Shaping Immune Responses in the Lymph Node Microenvironment

Biology of the Cell, Volume 118, Issue 10, October 2026.
Functional alliances of stromal, innate and adaptive immune cells in EV immunity in the lymph node. EV reflect the phenotype of their mother cell and cluster material from their surroundings. In the lymph node, EV preserve valuable context information between multiple cellular effectors to coordinate immunity in adaption to change.
Alicia Charrier, Apolline Salama, Laurence Dubreil, Grégoire Mignot, Steffi Bosch   +4 more
wiley   +1 more source

Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis

, 2017
Background and Purpose: The sphingosine analogue, FTY720 (GilenyaR), alleviates clinical disease progression in multiple sclerosis. Here, we variously assessed the effects of an azide analogue of (S)-FTY720 vinylphosphonate (compound 5; a sphingosine
Melissa McNaughton, MacRitchie, Neil, Pyne, Nigel J., Neil MacRitchie, Boomkamp, Stephanie D., Pyne, Susan, Mark Barbour, Stephanie D Boomkamp, Hui‐Rong Jiang, Nigel J Pyne, McNaughton, Melissa, Barbour, Mark, Susan Pyne, Jiang, Hui-Rong   +13 more
core   +1 more source

Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study

International Endodontic Journal, Volume 59, Issue 10, Page 2211-2222, October 2026.
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco, David Uroz‐Torres, Ana Soriano‐Lerma, Miguel Soriano, Jose Antonio García‐Salcedo, Maria Teresa Arias‐Moliz   +5 more
wiley   +1 more source

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1626-1647, October 2026.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

Journal of Internal Medicine, Volume 300, Issue 4, Page 461-479, October 2026.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source

Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2

, 2007
In yeast, the long-chain sphingoid base phosphate phosphohydrolase Lcb3p is required for efficient ceramide synthesis from exogenous sphingoid bases.
H. Le Stunff, P. Giussani, S. Milstien, M. Maceyka, S. Spiegel, S. Lépine   +5 more
core   +1 more source

Stopping Sepsis by Targeting Sphingosine Kinase 1

, 2010
A recent study suggests that inhibiting the enzyme sphingosine kinase 1 might have great potential as a therapy for sepsis.
Luke A. J. O’Neill
core   +1 more source

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells : functional differences between sphingosine kinase 1a and 1b

, 2012
Sphingosine kinase 1 catalyses the formation of the bioactive lipid, sphingosine 1-phosphate and is a target for anti-cancer agents. We demonstrate here that 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole (SKi, also referred to as SKI-II), FTY720 ...
Leclercq, Tamara, Tonelli, Francesca Romana, Gorshkova, Irina, Pitson, Stuart M, Pyne, Susan, Berdyshev, Evgeny, Pyne, Nigel, Lim, Keng Gat, Bittman, Robert   +8 more
core   +3 more sources

The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib

Current Research in Pharmacology and Drug Discovery
Non-small-cell lung cancer (NSCLC) represents a predominant histological subtype of lung cancer, characterized by high incidence and mortality rates.
Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan   +6 more
doaj   +1 more source