Results 111 to 120 of about 30,319,267 (183)

Targeting sphingosine kinase 1 in p53KO thymic lymphoma. [PDF]

FASEB J, 2023
Velazquez FN, Stith JL, Zhang L, Allam AM, Haley J, Obeid LM, Snider AJ, Hannun YA.   +7 more
europepmc   +1 more source

Sphingosine kinase localization in the control of sphingolipid metabolism

, 2011
Link to a related website: http://europepmc.org/articles/pmc3079002?pdf=render, Open Access via UnpaywallThe sphingosine kinases (sphingosine kinase-1 and -2) have been implicated in a variety of physiological functions.
Pitson, S., Skobeleva, A., Anderson, C., Anastasia Skobeleva, Viswanathan Natarajan, Siow, D., Deanna L. Siow, Natarajan, V., Evgeny V. Berdyshev, Charles D. Anderson, Wattenberg, B., Stuart M. Pitson, Binks W. Wattenberg, Berdyshev, E.   +13 more
core   +1 more source

UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1. [PDF]

Cells, 2023
Epshtein Y, Mathew B, Chen W, Jacobson JR.   +3 more
europepmc   +1 more source

Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1

, 2006
We examined the involvement of sphingosine kinase-1, a critical regulator of the sphingolipid balance, in susceptibility to antineoplastic agents of either sensitive or multidrug-resistant acute myeloid leukemia cells.
Pchejetski, D, Morjani, H, Kohama, T, Aouali, N, Levade, T, Cuvillier, O, Bonhoure, E   +6 more
core   +1 more source

Synthesis and Analysis of Potential Sphingosine Kinase 1 Inhibitors

, 2018
The sphinogmyelin metabolic pathway is a popular target area of research due to the potential for apoptosis in cancer cells. In the pathway, sphinogmyelin may be converted to the final product of sphingosine-1-phosphate.
Manore, Sara
core   +1 more source

Regulation of arginase II expression in macrophages by supernatants of apoptotic cells [PDF]

, 2010
Apoptotic cell (AC)-derived factors alter the physiology of macrophages (M Phi s) towards a regulatory phenotype that is characterized by enhanced production of anti-inflammatory mediators, an attenuated pro-inflammatory cytokine profile and reduced ...
Barra, Vera
core  

Molecular docking analysis of sphingosine kinase 1 inhibitors for cancer management. [PDF]

Bioinformation, 2023
Barnawi J.
europepmc   +1 more source

Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes. [PDF]

J Lipid Res, 2023
Morishige JI, Yoshioka K, Nakata H, Ishimaru K, Nagata N, Tanaka T, Takuwa Y, Ando H.   +7 more
europepmc   +1 more source

Sphingosine kinase inhibitors

, 2015
Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both.

core  

Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review

Future Journal of Pharmaceutical Sciences
Background Dysregulated sphingolipid metabolism has emerged as a major pathway in multiple human cancers. Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier ...
Seemarani M. Pawar, Trupti Chitre, Prasad Dandawate   +2 more
doaj   +1 more source