Results 41 to 50 of about 26,969 (190)
Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P
Microbiology Spectrum, 2022 Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host.
Dev K. Ranjit +8 more
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Molecules, 2022 Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates and requires the development of highly efficacious medications that can improve the efficiency of existing treatment methods.
Khem Raj Limbu +4 more
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Pharmaceuticals, 2020 Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first ...
Sonam Roy +8 more
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Sphingosine kinase 1 in breast cancer
Advances in Biological Regulation, 2018 Breast cancer affects 1 out of 8 women in the US and is the second highest cause of death from cancer for women, leading to considerable research examining the causes, progression, and treatment of breast cancer. Over the last two decades, sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes important ...
Kurt, Geffken, Sarah, Spiegel
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Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
Cell Reports, 2016 Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis; however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in endocytic trafficking has not been established. Here, we demonstrate that
Megan M. Young +5 more
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Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy
Chinese Medical Journal, 2014 Objective Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide and its prevalence continues to increase. Currently, therapies for DN provide only partial renoprotection; hence new targets for therapeutic intervention need to be identified.
Yanhui, Deng +3 more
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Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
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PLoS ONE, 2015 Sphingosine kinase is a lipid kinase that converts sphingosine into sphingosine-1-phosphate, an important signaling molecule with intracellular and extracellular functions.
Yong-Seok Oh +5 more
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Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases
Liver Research, 2019 The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
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Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances [PDF]
Progress in Lipid Research, 2016 Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid, sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P-specific G protein coupled receptors but also has intracellular signalling roles.
Pyne, Susan +2 more
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