Results 21 to 30 of about 30,319,267 (183)
A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation [PDF]
, 2010 Sphingosine kinase 1 (SK1) is a key enzyme in the generation of sphingosine 1-phosphate (S1P) which critically regulates a variety of important cell responses such as proliferation and migration.
Xin, Cuiyan +3 more
core +2 more sources
A real-time high-throughput fluorescence assay for sphingosine kinases
Journal of Lipid Research, 2014 Sphingosine kinases (SphKs), of which there are two isoforms, SphK1 and SphK2, have been implicated in regulation of many important cellular processes. We have developed an assay for monitoring SphK1 and SphK2 activity in real time without the need for ...
Santiago Lima +2 more
doaj +1 more source
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]
, 2010 <b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Kane, K.A. +6 more
core +1 more source
Frontiers in Molecular Biosciences, 2021 BackgroundTriple-negative breast cancer (TNBC) features a poor prognosis, which is partially attributed to its high metastatic rate. However, there is no effective target for systemic TNBC therapy due to the absence of estrogen, progesterone, and human ...
Weiwei Shi +12 more
doaj +1 more source
The Role of Sphingolipids in the Pathogenesis of Psoriasis
Metabolites, 2022 Psoriasis is a complex, chronic, immunologically mediated disease which involves skin and joints. Psoriasis is commonly connected with numerous other diseases such as liver diseases, metabolic syndrome, impaired glucose tolerance, diabetes mellitus ...
Mateusz Matwiejuk +3 more
doaj +1 more source
PLoS ONE, 2016 Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality.
Aneta Dobierzewska +7 more
doaj +1 more source
Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases
Frontiers in Pharmacology, 2019 The central nervous system is characterized by a high content of sphingolipids and by a high diversity in terms of different structures. Stage- and cell-specific sphingolipid metabolism and expression are crucial for brain development and maintenance ...
Sara Grassi +6 more
doaj +1 more source
International Journal of Immunopathology and Pharmacology, 2021 Background: Sphingosine kinase has been identified as playing a central role in the immune cascade, being a common mediator in the cellular response to a variety of signals.
Yuval Ishay +2 more
doaj +1 more source
Fingolimod modulates microglial activation to augment markers of remyelination [PDF]
, 2011 Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin +8 more
core +1 more source
Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients
Walailak Journal of Science and Technology, 2016 The aim of this study was to investigate the expression of S1PR4 in colorectal cancer and its correlation with clinicopathologic characteristics. Paraffin-embedded colorectal cancer samples and matched adjacent normal tissues were collected from 32 ...
Suchittra SAMUHASANEETO +2 more
doaj +1 more source