Results 21 to 30 of about 26,969 (190)

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis.

PLoS ONE, 2013
ObjectiveExperimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
doaj   +1 more source

Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice

Acta Dermato-Venereologica, 2019
Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis.
Sun-Hye Shin, Kyung-Ah Cho, Soojung Hahn, Younghay Lee, Yu-He Kim, So-Youn Woo, Kyung-Ha Ryu, Woo-Jae Park, Joo-Won Park   +8 more
doaj   +1 more source

Bile acids as global regulators of hepatic nutrient metabolism

Liver Research, 2017
Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon, Kazuaki Takabe, Mikhail Dozmorov, Masayuki Nagahashi, Huiping Zhou   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine

Marine Drugs, 2015
A series of carbocyclic analogues of naturally-occurring marine sphingolipid pachastrissamine were prepared and biologically evaluated. The analogues were efficiently synthesized via a tandem enyne/diene-ene metathesis reaction as a key step.
Yongseok Kwon, Jayoung Song, Hoon Bae, Woo-Jung Kim, Joo-Youn Lee, Geun-Hee Han, Sang Kook Lee, Sanghee Kim   +7 more
doaj   +1 more source

Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT

Frontiers in Immunology, 2018
Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara, Rosa Muñoz-Cano, Araceli Tobío, Yuzhi Yin, Hirsh D. Komarow, Avanti Desai, Dean D. Metcalfe, Ana Olivera   +7 more
doaj   +1 more source

Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.

PLoS ONE, 2012
The pathogenesis of inflammation in the central nervous system (CNS), which contributes to numerous neurodegenerative diseases and results in encephalopathy and neuroinflammation, is poorly understood.
Natalia M Grin'kina, Eddy E Karnabi, Dushyant Damania, Sunil Wadgaonkar, Ilham A Muslimov, Raj Wadgaonkar   +5 more
doaj   +1 more source

Loss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans

Frontiers in Genetics, 2017
Sphingolipid metabolism is important to balance the abundance of bioactive lipid molecules involved in cell signaling, neuronal function, and survival. Specifically, the sphingolipid sphingosine mediates cell death signaling, whereas its phosphorylated ...
Jason P. Chan, Jaylene Brown, Brandon Hark, Abby Nolan, Dustin Servello, Hannah Hrobuchak, Trisha A. Staab   +6 more
doaj   +1 more source

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking [PDF]

Journal of Biological Chemistry, 2017
The balance between cholesterol and sphingolipids within the plasma membrane has long been implicated in endocytic membrane trafficking. However, in contrast to cholesterol functions, little is still known about the roles of sphingolipids and their metabolites.
Santiago, Lima, Sheldon, Milstien, Sarah, Spiegel   +2 more
openaire   +2 more sources

A real-time high-throughput fluorescence assay for sphingosine kinases

Journal of Lipid Research, 2014
Sphingosine kinases (SphKs), of which there are two isoforms, SphK1 and SphK2, have been implicated in regulation of many important cellular processes. We have developed an assay for monitoring SphK1 and SphK2 activity in real time without the need for ...
Santiago Lima, Sheldon Milstien, Sarah Spiegel   +2 more
doaj   +1 more source