Results 11 to 20 of about 26,969 (190)
The Functional Role of Sphingosine Kinase 2
Frontiers in Molecular Biosciences, 2021 Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and
Rocio Diaz Escarcega +5 more
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Sphingosine Kinase 1 – A Therapeutic Opportunity for Alleviating Liver Fibrosis? [PDF]
Cellular and Molecular Gastroenterology and HepatologyJia Ming Nickolas Teo, Guang Sheng Ling
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Frontiers in Molecular Biosciences, 2021 Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii +7 more
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Cellular signalling by sphingosine kinase and sphingosine 1‐phosphate [PDF]
IUBMB Life, 2006 AbstractSphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1‐phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular maturation. The last few years have seen a number of significant advances in understanding of the
Leclercq, T., Pitson, S.
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Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer [PDF]
Discover Oncology, 2021 AbstractSphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intracellularly produced S1P is delivered to the extracellular
Guangmeng Xu +4 more
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Timothy, Rohrbach +2 more
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Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013 Sphingosine 1-phosphate (S1P) is an important bioactive sphingolipid metabolite that has been implicated in numerous physiological and cellular processes. Not only does S1P play a structural role in cells by defining the components of the plasma membrane, but in the last 20 years it has been implicated in various significant cell signaling pathways and
K Alexa, Orr Gandy, Lina M, Obeid
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Sphingosine Kinase 1 in Cancer [PDF]
, 2013 The role of sphingolipids as bioactive signaling molecules that can regulate cell fate decisions puts them at center stage for cancer treatment and prevention. While ceramide and sphingosine have been established as antigrowth molecules, sphingosine-1-phosphate (S1P) offers a progrowth message to cells.
Linda A, Heffernan-Stroud, Lina M, Obeid
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Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection [PDF]
Journal of Cardiovascular Pharmacology, 2009 Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset ...
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Sphingosine kinase and sphingosine 1-phosphate in asthma
Bioscience Reports, 2010 Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai +2 more
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