Results 71 to 80 of about 30,263,703 (145)

Inhibiting sphingosine 1-phosphate lyase: From efficacy to mechanism

Neurobiology of Disease
Sphingosine-1 phosphate (S1P) is a lipid metabolite regulating diverse biological processes, including proliferation, differentiation, migration, and apoptosis, highlighting its physiological and therapeutic significance.
Nelson George, Junhua Xiao
doaj   +1 more source

Macrophage polarization by apoptotic cancer cells - a RNAi high-throughput screen and validation of interleukin 10 regulation [PDF]

, 2012
Tumor-associated macrophages (TAM) are a major supportive component within neoplasms and by their plasticity promote all phases of tumor development. Mechanisms of macrophage (M Phi) attraction and differentiation to a tumor-promoting phenotype, defined ...
Ley, Stephanie
core  

Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy

, 2007
Sphingolipids not only function as structural components of cell membranes but also act as signaling molecules to regulate fundamental cellular responses, such as cell death and differentiation, proliferation and certain types of inflammation ...
Zangemeister-Wittke, Uwe, Huwiler, Andrea   +1 more
core   +1 more source

Function and Modulation of Sphingosine-1-Phosphate Receptors in the Central Nervous System

Receptors
Sphingolipids, first discovered in 1874 by Johann Thudicum, are among the eight recognized classes of lipids and are present in essentially all plants, animals, and fungi, as well as some viruses and prokaryotes. In mammals, sphingolipids are enriched in
Elizabeth Gulliksen, Sriya Darsi, Ladan Haidarbaigi, Lucas J. Codispoti, Devam Purohit, Ashley Jung, Aishwarya Chilamula, Jason Newton   +7 more
doaj   +1 more source

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation

, 2020
Acute myeloid leukemia (AML) is a caricature of normal hematopoiesis driven from leukemia stem cells (LSC) that share some hematopoietic stem cell (HSC) programs including responsiveness to inflammatory signaling.
Kaufmann, Kerstin B., Wang, Weijia, Gan, Olga I., Xie, Stephanie Z., Chan-Seng-Yue, Michelle   +4 more
core  

Structure and mechanism of human sphingosine-1-phosphate transporter MFSD2B. [PDF]

Nat Commun
Ahmed S, Huang M, Dai Y, Yang X, Dong J, Yu X, Lee CH, Nguyen LN.   +7 more
europepmc   +1 more source

Sphingosine-1-Phosphate Attenuates LPS-Induced Inflammatory Cardiac Injury in Association With RASGRP1-S100A9-NLRP3 Signaling. [PDF]

Drug Dev Res
Yue C, Li Q, Li C, Yang T, Huang X, Yue F, Long Q, Li R, Lei R, Ma Q, Hu C, Yang Q, Yan Y, Liu Y, Yan Q, Yang M.   +15 more
europepmc   +1 more source

Expression of Concern: Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate. [PDF]

Clin Sci (Lond)
Roviezzo F, De Angelis A, De Gruttola L, Bertolino A, Sullo N, Brancaleone V, Bucci M, De Palma R, Urbanek K, D'Agostino B, Ianaro A, Sorrentino R, Cirino G.   +12 more
europepmc   +1 more source

Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5. [PDF]

Nat Commun
Qian X, Ge R, Chu Y, Kuang T, Zhang X, Bennewitz K, Lou B, Hao W, Ast V, Klinke G, Poschet G, Morgenstern J, Fleming T, Hausser I, Szendroedi J, Nawroth PP, Kroll J.   +16 more
europepmc   +1 more source

Potential Role of Sphingosine-1-Phosphate and Its Receptors in the Reparative Processes of the Adult Brain. [PDF]

Int J Mol Sci
Gutner UA, Shupik MA, Alessenko A.
europepmc   +1 more source