Results 91 to 100 of about 327,382 (312)

Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3 [PDF]

, 2015
BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts through a family of five G-protein-coupled receptors (S1PR1-5) and plays a key role in regulating the inflammatory response.
Guerrero, Miguel, Kays, Joanne, Li, Chao, Li, Jun-nan, Nicol, Grant D.   +4 more
core   +1 more source

Endothelial Functions of Sphingosine-1-phosphate

Cellular Physiology and Biochemistry, 2010
The biologically active sphingolipid sphingosine-1-phosphate (S1P) plays key functions in the immune, inflammatory, and cardiovascular systems. In the vasculature, S1P and its receptors are involved in vessel morphogenesis and angiogenesis during embryonic development and in the adult organism both under normal and pathological conditions.
Lucke, Susann, Levkau, Bodo
openaire   +2 more sources

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Sphingosine‐1‐phosphate: dual messenger functions

FEBS Letters, 2002
The sphingolipid metabolite sphingosine‐1‐phosphate (S1P) is a serum‐borne lipid that regulates many vital cellular processes. S1P is the ligand of a family of five specific G protein‐coupled receptors that are differentially expressed in different tissues and regulate diverse cellular actions. Much less is known of the intracellular actions of S1P. It
Payne, Shawn G, Milstien, Sheldon, Spiegel, Sarah   +2 more
openaire   +2 more sources

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Science immunology, 2019
Sphingosine 1-phosphate engages multiple T cell and lymphatic endothelial cell receptors to regulate lymphocyte migration. Getting immune cells home Immune cells are recruited to tissues from the lymphatic system via efferent lymphatics in response to ...
Yanbao Xiong, Wenji Piao, C. Brinkman, Lushen Li, Joseph M. Kulinski, A. Olivera, Andreane Cartier, Andreane Cartier, T. Hla, T. Hla, K. Hippen, B. Blazar, Susan R. Schwab, Jonathan S. Bromberg   +13 more
semanticscholar   +1 more source

Association of Neurodevelopmental Disorders and Congenital Anomalies With Prenatal Multiple Sclerosis Treatment—Real‐World Historical Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh, Ofek Levi, Nili Stein, Amir Yahav, Naomi Gronich   +4 more
wiley   +1 more source

Sphingosine‐1‐phosphate stimulates cortisol secretion

FEBS Letters, 2003
We show here for the first time that sphingosine‐1‐phosphate (Sph‐1‐P) stimulates cortisol secretion in zona fasciculata cells of bovine adrenal glands. This effect was dependent upon protein kinase C (PKC) and extracellular Ca2+, and was inhibited by pertussis toxin. Sph‐1‐P activated phospholipase D (PLD) through a pertussis toxin‐sensitive mechanism,
Rábano, Miriam, Peña, Ana, Brizuela, Leyre, Marino, Aida, Macarulla, José Marı́a, Trueba, Miguel, Gómez-Muñoz, Antonio   +6 more
openaire   +2 more sources

T-Cell Accumulation in the Hypertensive Brain: A Role for Sphingosine-1-Phosphate-Mediated Chemotaxis

International Journal of Molecular Sciences, 2019
Hypertension is considered the major modifiable risk factor for the development of cognitive impairment. Because increased blood pressure is often accompanied by an activation of the immune system, the concept of neuro-inflammation gained increasing ...
Nicholas Don-Doncow, Lotte Vanherle, Yun Zhang, A. Meissner   +3 more
semanticscholar   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target [PDF]

, 2020
It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes.
Alshaker, Heba, Pchejetski, Dmitri, Thrower, Hannah   +2 more
core   +1 more source