Results 91 to 100 of about 21,457,228 (260)

Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy

, 2007
Sphingolipids not only function as structural components of cell membranes but also act as signaling molecules to regulate fundamental cellular responses, such as cell death and differentiation, proliferation and certain types of inflammation ...
Zangemeister-Wittke, Uwe, Huwiler, Andrea   +1 more
core   +1 more source

Longitudinal Single‐Cell Transcriptomic Profiling Reveals Dynamic Immune Cell Alterations During Burosumab Therapy in X‐Linked Hypophosphatemia

Pediatric Discovery, EarlyView.
This longitudinal single‐cell study reveals dynamic immune remodeling during burosumab therapy in pediatric X‐linked hypophosphatemia (XLH), highlighting coordinated changes in T cell subtypes (Th2, Th17, and Treg) and natural killer cell subtypes (NK2 and NK3) and immune pathways linked to osteoclast differentiation and treatment response.
Yue Xie, Li Li, Rong Li, Yihong Sun, Ting Zhou, Yupeng Cun, Gaohui Zhu   +6 more
wiley   +1 more source

Rôle de la sphingosine 1-phosphate dans les interactions mélanome-stroma

, 2012
Le mélanome métastatique demeure un cancer au sombre pronostic, et aucune des thérapies conventionnelles n'a pu apporter de bénéfice sur la survie globale.
Albinet, Virginie
core  

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

The Role of Sphingolipid Metabolism in Pregnancy-Associated Breast Cancer After Chemotherapy

Biomedicines
Background: The aim of our study was to determine the role of sphingolipids, which control proliferation and apoptosis, in the placenta of pregnant women with pregnancy-associated breast cancer (PABC) after chemotherapy compared with healthy patients ...
Victor Blokhin, Tatiana Zavarykina, Vasily Kotsuba, Maria Kapralova, Uliana Gutner, Maria Shupik, Elena Kozyrko, Evgenia Luzina, Polina Lomskova, Darya Bajgazieva, Svetlana Khokhlova, Alice Alessenko   +11 more
doaj   +1 more source

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia.

PLoS ONE, 2016
Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality.
Aneta Dobierzewska, Macarena Palominos, Marianela Sanchez, Michael Dyhr, Katja Helgert, Pia Venegas-Araneda, Stephen Tong, Sebastian E Illanes   +7 more
doaj   +1 more source

Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection

, 2011
High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and the ...
Hacking, Damian
core  

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the sphingosine-1-phosphate receptor 2 [PDF]

, 2018
Objectives: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses.
Lies, A., Haberberger, Rainer, Gruber, Achim D., Bauer, Torsten T., Rupp, J., Schönrock, Stefanie M., Treue, Denise, Knüppel, W., Abrahamczik, M., Langner, S., Gutbier, Birgitt, Hocke, Andreas C., Letsiou, Eleftheria, Welte, T., Kuebler, Wolfgang M., Dietert, Kristina, Ehrler, Carolin, Hippenstiel, Stefan, Schumacher, Fabian, Ewig, S., Tönnies, Mario, Dreher, M., Cornelissen, C., Prediger, M., Szymanski, Kolja, Bertrams, Wilhelm, Schulte-Hubbert, B., Thiemig, D., Pankow, W., Weissmann, Norbert, Kleuser, Burkhard, Mitchell, Timothy J., Klauschen, Frederick, Schmeck, Bernd, Naim, J., Stolz, D., Kummer, Wolfgang, Schmager, S., Creutz, P., Witzenrath, Martin, Suttorp, Norbert, Lüth, Anja, Pletz, M., Kolditz, M., Michalick, Laura, Wehde, D., Sabha, T., Hauptmeier, B., Barten, G., Rohde, G.   +49 more
core   +2 more sources

Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease[S]

Journal of Lipid Research, 2019
Sphingosine phosphate lyase (SPL) is the final enzyme in the sphingolipid degradative pathway, catalyzing the irreversible cleavage of long-chain base phosphates (LCBPs) to yield a long-chain aldehyde and ethanolamine phosphate (EP).
Julie D. Saba
doaj   +1 more source