Results 111 to 120 of about 37,566 (200)

Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki, Mercè Pallàs, Carmen Escolano   +2 more
wiley   +1 more source

Sphingosine-1-Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis. [PDF]

Acta Physiol (Oxf)
Bozzini N, Cortini M, Righi A, Grigoriadis AE, Dack M, Ilieva E, Torricelli F, Manicardi V, Baldini N, Avnet S.   +9 more
europepmc   +1 more source

Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5. [PDF]

Nat Commun
Qian X, Ge R, Chu Y, Kuang T, Zhang X, Bennewitz K, Lou B, Hao W, Ast V, Klinke G, Poschet G, Morgenstern J, Fleming T, Hausser I, Szendroedi J, Nawroth PP, Kroll J.   +16 more
europepmc   +1 more source

Sphingosine-1-Phosphate as an Immune-Metabolic Biomarker in Neurodegenerative Diseases. [PDF]

J Clin Neurol
Kim SH, Jin HK, Bae JS.
europepmc   +1 more source

SPNS2 exports sphingosine-1-phosphate and imports glucose. [PDF]

Nat Commun
Weigel C, Hossen ML, Brown RDR, Senkal CE, Green CD, Newton J, Saha S, Palladino END, Ni B, Celi FS, Fang X, Corwin FD, Li HZ, Sauer DB, Chapagain PP, Spiegel S.   +15 more
europepmc   +1 more source

The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues. [PDF]

J Endocr Soc
Mbadhi MN, Fujiwara H, Gill R, Mitchum KT, Lin ZC, Raghuraman N, Frolova AI.   +6 more
europepmc   +1 more source

Mechanistic insights and therapeutic potential of sphingosine‑1‑phosphate in the development of pulmonary fibrosis (Review). [PDF]

Mol Med Rep
Qin Y, Tang C, Tan S, Liu G.
europepmc   +1 more source

The potential effect of albumin replacement on immune modulation and sphingosine 1-phosphate dynamics. [PDF]

Sci Rep
Winkler MS, Enzmann F, Schilder M, Seidita I, Moerer O, Gräler MH.   +5 more
europepmc   +1 more source

Structural insights into subtype-specific agonist recognition by sphingosine-1-phosphate receptors. [PDF]

PLoS Biol
Yu L, Jiao H, Pang B, Ti R, Gan B, Qin Z, Wang J, Zhu L, Hu H, Ren R.   +9 more
europepmc   +1 more source

Clinical Significance of Plasma Sphingosine-1-Phosphate Decline in Progression of Spinal and Bulbar Muscular Atrophy. [PDF]

J Clin Neurol
Jung YH, Seok HY, Kang M, Do YW, Park JO, Kim JH, Park JS.   +6 more
europepmc   +1 more source