Results 131 to 140 of about 327,382 (312)

S1P-S1PR1 Signaling: the “Sphinx” in Osteoimmunology

Frontiers in Immunology, 2019
The fundamental interaction between the immune and skeletal systems, termed as osteoimmunology, has been demonstrated to play indispensable roles in the maintenance of balance between bone resorption and formation. The pleiotropic sphingolipid metabolite,
Lan Xiao, Lan Xiao, Yinghong Zhou, Yinghong Zhou, Yinghong Zhou, Thor Friis, Kenneth Beagley, Kenneth Beagley, Yin Xiao, Yin Xiao, Yin Xiao   +10 more
doaj   +1 more source

Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design. [PDF]

, 2020
Purpose of review:This review summarizes recent literature defining tissue-resident memory T cells (TRM) and discusses implications for HIV pathogenesis, vaccines, and eradication efforts.Recent findings:Investigations using animal models and human ...
Ferre, April L, Kiniry, Brenna E, Shacklett, Barbara L   +2 more
core  

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis [PDF]

, 2016
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the ...
Bauer, M, Benetti, E, Coldewey, SM, Collino, M, Huwiler, A, Pfeilschifter, J, Sponholz, C, Thiemermann, C   +7 more
core   +3 more sources

Paradoxical Effects of Sphingosine-1-Phosphate [PDF]

Journal of Investigative Dermatology, 2003
When an enzyme is mentioned in the White House, even if only in the world of the popular television drama West Wing, it is clear that this enzyme has earned a wide reputation. So the statement of a female doctor attending the First Lady's dinner party indicating that sphingosine kinase controls "all signal pathways to cancer growth" suggests that this ...
openaire   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Sphingosine 1-Phosphate Receptor Modulator ONO-4641 Regulates Trafficking of T Lymphocytes and Hematopoietic Stem Cells and Alleviates Immune-Mediated Aplastic Anemia in a Mouse Model [PDF]

, 2020
Takaki Komiya, Masashi Gohda, Hiroki Shioya, Seishi Katsumata   +3 more
openalex   +1 more source

Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat [PDF]

, 2012
Three bioactive sphingolipids, namely sphingosine-1-phosphate (S1P), ceramide (CER) and sphingosine (SPH) were shown to be involved in ischemia/reperfusion injury of the heart.
Agnieszka Błachnio-Zabielska, Jan Górski, Krzysztof Kurek, Małgorzata Knapp, Małgorzata Żendzian-Piotrowska, Piotr Zabielski   +5 more
core   +1 more source

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

British Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand, Simone Brogi, Mustafa Tezeren, Andrea Tafi, Omer H. Ocak, Hasan Koyuncu, Igor Tetko, Laurent Désaubry, Canan G. Nebigil   +8 more
wiley   +1 more source

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis.

PLoS ONE, 2013
ObjectiveExperimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source

Enzymatic Measurement of Sphingosine 1-Phosphate

Analytical Biochemistry, 1999
Sphingosine 1-phosphate (SPP) is a sphingolipid metabolite which has novel dual actions acting as both an intracellular second messenger and a ligand for a family of G protein-coupled receptors. This paper describes a rapid enzymatic method to quantify mass levels of SPP in serum, mammalian tissues, and cultured cells.
L C, Edsall, S, Spiegel
openaire   +2 more sources