Results 121 to 130 of about 327,382 (312)

Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease[S]

Journal of Lipid Research, 2019
Sphingosine phosphate lyase (SPL) is the final enzyme in the sphingolipid degradative pathway, catalyzing the irreversible cleavage of long-chain base phosphates (LCBPs) to yield a long-chain aldehyde and ethanolamine phosphate (EP).
Julie D. Saba
doaj   +1 more source

Decision letter for "The emerging role of FTY720 as a sphingosine 1‐phosphate analog for the treatment of ischemic stroke: The cellular and molecular mechanisms"

, 2021

openalex   +1 more source

P138 Preclinical and clinical characterization of cenerimod, a potent, selective, and orally active sphingosine-1-phosphate receptor 1 modulator in SLE [PDF]

, 2020
Daniel S. Strasser, Estelle Gerossier, Virginie Sippel, Ursula Grieder, Andrea Kieninger‐Gräfitsch, Gabin Pierlot, Hervé Farine, Paulina Kulig, Marcel P. Keller, Sylvie Froidevaux, Marten Trendelenburg, Mark Murphy, Marianne M. Martinic   +12 more
openalex   +1 more source

The role of external broadcasting in a closed political system [PDF]

, 2011
This article investigates the role and impact of external broadcasting (radio and television) on a closed political system, through the example of the two post-war German states: the West German Federal Republic of Germany (FRG) and the East German ...
Andreas Scheu, Browne DR, Castells M., Corbin J., DeFleur ML, Der Spiegel, Hafez K., Hahn O., Hesse KR, Hopkins M., Hyman HH, Infratest, Infratest, Infratest, Infratest, Jansen M., Lindlof T., McQuail D., Merritt AJ, Merritt AJ, Meyen M., Michael Meyen, Parta RE, Perse EM   +23 more
core   +2 more sources

Sphingosine 1-phosphate receptor-targeted therapeutics in rheumatic diseases

Nature Reviews Rheumatology, 2022
N. Burg, J. Salmon, T. Hla
semanticscholar   +1 more source

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

The Role of Sphingolipid Metabolism in Pregnancy-Associated Breast Cancer After Chemotherapy

Biomedicines
Background: The aim of our study was to determine the role of sphingolipids, which control proliferation and apoptosis, in the placenta of pregnant women with pregnancy-associated breast cancer (PABC) after chemotherapy compared with healthy patients ...
Victor Blokhin, Tatiana Zavarykina, Vasily Kotsuba, Maria Kapralova, Uliana Gutner, Maria Shupik, Elena Kozyrko, Evgenia Luzina, Polina Lomskova, Darya Bajgazieva, Svetlana Khokhlova, Alice Alessenko   +11 more
doaj   +1 more source

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia.

PLoS ONE, 2016
Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality.
Aneta Dobierzewska, Macarena Palominos, Marianela Sanchez, Michael Dyhr, Katja Helgert, Pia Venegas-Araneda, Stephen Tong, Sebastian E Illanes   +7 more
doaj   +1 more source

Sphingosine‐1‐phosphate receptors and innate immunity

Cellular Microbiology, 2018
Sphingosine‐1‐phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well‐studied role of S1P signalling is to modulate T‐cell trafficking, which has a major impact on adaptive immunity.
Arielle M. Bryan, M. Del Poeta
semanticscholar   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source