Results 1 to 10 of about 1,067 (90)

Regulation of immunity by lysosphingolipids and their G protein–coupled receptors [PDF]

Journal of Clinical Investigation, 2004
T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines.
Edward J, Goetzl, Hugh, Rosen
openaire   +2 more sources

Genetic ablation of Saposin‐D in Krabbe disease eliminates psychosine accumulation but does not significantly improve demyelination

Journal of Neurochemistry, Volume 166, Issue 4, Page 720-746, August 2023., 2023
We revisited the “psychosine hypothesis” in the pathogenesis of Krabbe disease (KD) by characterizing Twitcher mice (Twi) lacking saposin D (Sap‐D) (Twi/Sap‐D KO). Twi/Sap‐D KO were found to almost completely abolish psychosine accumulation in both the CNS and PNS, however, exhibited comparable demyelination to Twi, especially in the PNS.
Takashi Watanabe, Kazuhito Tsuboi, Nobuaki Matsuda, Yuta Ishizuka, Shinji Go, Etsuko Watanabe, Ayaka Ono, Yasuo Okamoto, Junko Matsuda   +8 more
wiley   +1 more source

Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.

FEBS letters, 1998
The structural similarity of lysosphingolipids to lysophosphatidic acid (LPA) prompted a sequence-based search for lysosphingolipid receptors using cDNA sequence of the Edg2 human LPA receptor. Two closely related G protein-coupled receptors, rat H218 and human Edg3, are highly similar to Edg2.
S, An, T, Bleu, W, Huang, O G, Hallmark, S R, Coughlin, E J, Goetzl   +5 more
openaire   +2 more sources

Hyperglycaemic hyperosmolar state and cerebral thrombophlebitis in paediatrics: A case report

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 2, March 2023., 2023
Emergency physicians should be aware of HHS in order to start the appropriate treatment as soon as possible and to think about its acute complication. This case highlights the importance to restore euvolemia before insulin treatment and decrease very gradually the osmolarity in order to avoid cerebral complication.
Maud Injeyan, Sabine Baron, Benjamin Lauzier, Benedicte Gaillard‐Le Roux, Manon Denis   +4 more
wiley   +1 more source

Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 9, Page 819-825, September 2022., 2022
Abstract The protein expression of gelsolin, an actin scavenger controlling cytoskeletal remodeling, cell morphology, differentiation, movement, and apoptosis, has been found to be significantly decreased in several pathological conditions including neurodegenerative diseases, inflammatory disorders, and cancers.
Chih‐Hsiung Hsieh, Yi‐Ching Wang
wiley   +1 more source

A cross‐sectional, prospective ocular motor study in 72 patients with Niemann‐Pick disease type C

European Journal of Neurology, Volume 28, Issue 9, Page 3040-3050, September 2021., 2021
In this largest cohort of patients with Niemann‐Pick type C disease examined so far, we found that vertical supranuclear saccade (VSSP), and not gaze palsy (VSGP), is the hallmark of this disease. We also identify the surrogate biomarkers that can be used in clinical trials to track the disease progress and treatment effect.
Tatiana Bremova‐Ertl, Larry Abel, Mark Walterfang, Ettore Salsano, Anna Ardissone, Věra Malinová, Miriam Kolníková, Jordi Gascón Bayarri, Ali Reza Tavasoli, Mahmoud Reza Ashrafi, Yasmina Amraoui, Eugen Mengel, Stefan A. Kolb, Andreas Brecht, Stanislavs Bardins, Michael Strupp   +15 more
wiley   +1 more source

Cingulate networks associated with gray matter loss in Parkinson's disease show high expression of cholinergic genes in the healthy brain

European Journal of Neuroscience, Volume 53, Issue 11, Page 3727-3739, June 2021., 2021
Earlier magnetic resonance imaging (MRI) studies identified brain networks referred to as structural covariance networks (SCNs) for which two were associated with gray matter loss in Parkinson’s disease: the posterior cingulate network and anterior cingulate network.
Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D.J. van de Berg, Jacobus J. van Hilten, Marcel J.T. Reinders, Ahmed Mahfouz   +7 more
wiley   +1 more source

Integrating GEO Database, Mendelian Randomization, and Molecular Docking to Identify HLA-C as a Potential Therapeutic Target for Periodontitis. [PDF]

Mediators Inflamm
Background: Periodontitis is a chronic inflammatory disease that leads to the destruction of periodontal tissues, ultimately resulting in tooth loss. Current treatments primarily focus on mitigating inflammation and alleviating symptoms, but they often lack specificity.
Shi C, Ou X, Huang L, Lei X, Xu S, Ou M, Li W, Zhao X.   +7 more
europepmc   +2 more sources

An Overview of the Biological Complexity of Vitiligo. [PDF]

Oxid Med Cell Longev
Vitiligo is a skin disease that affects all ethnicities and genders and is characterized by the loss of pigment essentially due to the selective loss of melanocytes. Although it is generally considered a systemic disease associated with polymorphisms in genes involved in the immune response, vitiligo is also considered an oxidative imbalance‐associated
Matarrese P, Puglisi R, Mattia G, Samela T, Abeni D, Malorni W.   +5 more
europepmc   +2 more sources

Pertussis toxin inhibits phospholipase C activation and Ca2+ mobilization by sphingosylphosphorylcholine and galactosylsphingosine in HL60 leukemia cells. Implications of GTP-binding protein-coupled receptors for lysosphingolipids.

The Journal of biological chemistry, 1995
Extracellular sphingosylphosphorylcholine (SPC) and galactosylsphingosine (psychosine) induced Ca2+ mobilization in a dose-dependent manner in HL60 leukemia cells. The rapid and transient increase in intracellular Ca2+ concentration ([Ca2+]i) elicited by SPC and psychosine at concentrations lower than 30 microM was inhibited by treatment of the cells ...
F, Okajima, Y, Kondo
openaire   +2 more sources