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Lysophospholipid receptors in neurodegeneration and neuroprotection [PDF]
Exploration of Neuroprotective TherapyThe central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
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Lysophospholipid receptors in vertebrate development, physiology, and pathology
Journal of Lipid Research, 2009 Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s.
Athanasia Skoura, Timothy Hla
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Lysophospholipid receptors in drug discovery [PDF]
Experimental Cell Research, 2015 Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively.
Yasuyuki, Kihara +2 more
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Lipids in Health and Disease, 2021 Background Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for ...
Manisha Ray +3 more
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Insights into the pharmacological relevance of lysophospholipid receptors [PDF]
British Journal of Pharmacology, 2012 The discovery of lysophospholipid (LP) 7‐transmembrane, G protein‐coupled receptors (GPCRs) that began in the 1990s, together with research into the functional roles of the major LPs known as lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P), have opened new research avenues into their biological processes and mechanisms.
Tetsuji, Mutoh +2 more
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Advances in lysophosphatidic acid for bone remodeling [PDF]
Kouqiang yixueLysophosphatidic acid (LPA), a simple bioactive lysophospholipid widely dispersed in human body, has been reported to regulate the proliferation, chemotaxis and differentiation of multiple cells and further participate in various developmental and ...
ZHANG Qin, XIANG Lin, GONG Ping
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Roles of polyunsaturated fatty acids, from mediators to membranes
Journal of Lipid Research, 2020 PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding their precise roles and modes of action remains challenging. PUFAs are precursors for a plethora of signaling lipids, for which knowledge about synthetic pathways and ...
Takeshi Harayama, Takao Shimizu
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Journal of Pharmacological Sciences, 2022 Lysophosphatidic acid (LPA) is a biologically active lysophospholipid, and acts on six types of LPA receptors (LPA1-LPA6). LPA-LPA1 signaling has been suggested as a therapeutic target for inflammatory and fibrotic disorders, including renal fibrosis.In ...
Takumi Naruse +2 more
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Lysophospholipids and their receptors in the central nervous system [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013 Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied lysophospholipids, are known to influence diverse biological events, including organismal development as well as function and pathogenesis within multiple organ systems.
Ji Woong, Choi, Jerold, Chun
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Novel lysophosphoplipid receptors: their structure and function
Journal of Lipid Research, 2014 It is now accepted that lysophospholipids (LysoGPs) have a wide variety of functions as lipid mediators that are exerted through G protein-coupled receptors (GPCRs) specific to each lysophospholipid.
Kumiko Makide +6 more
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