Results 11 to 20 of about 2,946 (161)

Lysophospholipid receptors in drug discovery [PDF]

Experimental Cell Research, 2015
Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively.
Yasuyuki, Kihara, Hirotaka, Mizuno, Jerold, Chun   +2 more
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Insights into the pharmacological relevance of lysophospholipid receptors [PDF]

British Journal of Pharmacology, 2012
The discovery of lysophospholipid (LP) 7‐transmembrane, G protein‐coupled receptors (GPCRs) that began in the 1990s, together with research into the functional roles of the major LPs known as lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P), have opened new research avenues into their biological processes and mechanisms.
Tetsuji, Mutoh, Richard, Rivera, Jerold, Chun   +2 more
openaire   +2 more sources

Lysophospholipids and their receptors in the central nervous system [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied lysophospholipids, are known to influence diverse biological events, including organismal development as well as function and pathogenesis within multiple organ systems.
Ji Woong, Choi, Jerold, Chun
openaire   +2 more sources

Lysophospholipid G Protein-coupled Receptors [PDF]

Journal of Biological Chemistry, 2004
The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
openaire   +2 more sources

Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse groups of G-protein-coupled receptors that are widely expressed and regulate decisive cellular functions.
Meyer zu Heringdorf, Dagmar, Jakobs, Karl H.   +1 more
openaire   +2 more sources

An update on the biology of sphingosine 1-phosphate receptors

Journal of Lipid Research, 2014
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily as an ex­tracellular signaling molecule. Signals initiated by S1P are transduced by five G protein-coupled receptors, named S1P1–5.
Victoria A. Blaho, Timothy Hla
doaj   +1 more source

A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay

Journal of Lipid Research, 2016
Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive signaling lysophospholipids that activate specific G protein-coupled receptors on the cell surface triggering numerous biological events.
Jonathan K. Fleming, Thomas R. Glass, Steve J. Lackie, Jonathan M. Wojciak   +3 more
doaj   +1 more source

Lysophospholipids and their G protein-coupled receptors in atherosclerosis [PDF]

Frontiers in Bioscience, 2016
Lysophospholipids (LPLs) are bioactive lipid-derived signaling molecules generated by the enzymatic and chemical processes of regiospecific phospholipases on substrates such as membrane phospholipids (PLs) and sphingolipids (SLs). They play a major role as extracellular mediators by activating G-protein coupled receptors (GPCRs) and stimulating diverse
Ya-Feng, Li, Rong-Shan, Li, Sonia B, Samuel, Ramon, Cueto, Xin-Yuan, Li, Hong, Wang, Xiao-Feng, Yang   +6 more
openaire   +3 more sources

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.

PLoS ONE, 2015
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid.
Aggeliki Katsifa, Eleanna Kaffe, Nefeli Nikolaidou-Katsaridou, Aris N Economides, Susan Newbigging, Colin McKerlie, Vassilis Aidinis   +6 more
doaj   +1 more source

Opposing Roles of S1P₃ Receptors in Myocardial Function

Cells, 2020
Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1–5 receptors. Whereas S1P was shown to protect the heart against ischemia/reperfusion (I/R) injury, other studies highlighted its ...
Dina Wafa, Nóra Koch, Janka Kovács, Margit Kerék, Richard L. Proia, Gábor J. Tigyi, Zoltán Benyó, Zsuzsanna Miklós   +7 more
doaj   +1 more source