Results 1 to 10 of about 32,066 (137)

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

Journal of Lipid Research, 2002
Lysophosphatidic acid is a multifunctional phospholipid mediator and elicits a variety of biological responses in vitro and in vivo. Evidence is accumulating that lysophosphatidic acid plays important physiological roles in diverse mammalian tissues and ...
Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, Akira Tokumura   +5 more
doaj   +3 more sources

Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

Cells, 2021
Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6).
Yu-Hsuan Lin, Yueh-Chien Lin, Chien-Chin Chen   +2 more
doaj   +3 more sources

Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
The intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from ...
C. Chris Yun, Yiran Han, Beth McConnell
doaj   +2 more sources

Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function [PDF]

Open Medicine
The specific role of lysophosphatidic acid 2 (LPA2) in deep vein thrombosis (DVT) remains unclear.
Bai Ruifeng, Yue Xinyang, Tian Xuan, Zhao Huiru, Liu Ying, Li Tian, Wu Jun   +6 more
doaj   +2 more sources

Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various Cancers

Frontiers in Oncology, 2022
A wide range of microRNAs (miRNAs) are coded for in the human genome and contribute to the regulation of gene expression. MiRNAs are able to degrade mRNAs and/or prevent the RNA transcript from being translated through complementary binding of the miRNA ...
Mahdi Rafiyan, Mahdi Rafiyan, Mohammad Hassan Jafari Najaf Abadi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Mahboubeh Mousavi, Hamed Mirzaei   +6 more
doaj   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

The contribution of lysophosphatidic acid receptors in the response of human lower esophageal sphincter under the electrical field stimulation

BMC Gastroenterology, 2023
Background This study aims to identify the impact on the reaction while the clasp and sling fibers of the human lower esophageal sphincter are under the electrical field stimulation, by adding lysophosphatidic acid receptor subtypes antagonist.
Yong Feng, Wei Wei, Liang Chen, Jun-Feng Liu   +3 more
doaj   +1 more source

2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition

Scientific Reports, 2021
Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo.
Keiko Fukasawa, Mari Gotoh, Akiharu Uwamizu, Takatsugu Hirokawa, Masaki Ishikawa, Yoshibumi Shimizu, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Junken Aoki, Kimiko Murakami-Murofushi   +10 more
doaj   +1 more source

Lysophosphatidic Acid Mediates Activating Transcription Factor 3 Expression Which Is a Target for Post-Transcriptional Silencing by miR-30c-2-3p. [PDF]

PLoS ONE, 2015
Although microRNAs (miRNAs) are small, non-protein-coding entities, they have important roles in post-transcriptional regulation of most of the human genome.
Ha T Nguyen, Wei Jia, Aaron M Beedle, Eileen J Kennedy, Mandi M Murph   +4 more
doaj   +1 more source

Supplementation of Culture Media with Lysophosphatidic Acid Improves The Follicular Development of Human Ovarian Tissue after Xenotransplantaion into The Back Muscle of γ-Irradiated Mice

Cell Journal, 2020
Objective: The aim of the present study was to evaluate the effects of lysophosphatidic acid (LPA) supplementation of human ovarian tissue culture media on tissue survival, follicular development and expression of apoptotic genes following ...
Zeynab Mohammadi, Nasim Hayati Roodbari, Kazem Parivar, Mojdeh Salehnia   +3 more
doaj   +1 more source