Results 21 to 30 of about 32,116 (179)
Molecular Pain, 2016 Background Lysophosphatidic acid receptor 1 and Rho/ROCK signaling is implicated in bone cancer pain development. However, it remains unknown whether the two signaling pathways function together in P2X 3 receptor-mediated bone cancer pain.
Jing-xiang Wu MD +4 more
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Role of lysophosphatidic acid as a mechanosensitizer
Folia Pharmacologica Japonica, 2004 The mechanotransduction mechanisms play an important role in regulation of specific cellular response or maintenance of cellular homeostasis in a wide variety of cell types. Increase in intracellular free Ca(2+) concentration ([Ca(2+)](i)) is an important signal in the first step of mechanotransduction. Mechanosensitive (MS) cation channels are thought
OHATA, Hisayuki +5 more
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Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
Nature Communications, 2016 Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as ...
Willem-Jan Keune +12 more
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Lysophosphatidic acid in atherosclerotic diseases [PDF]
British Journal of Pharmacology, 2012 Lysophosphatidic acid (LPA) is a potent bioactive phospholipid. As many other biological active lipids, LPA is an autacoid: it is formed locally on demand, and it acts locally near its site of synthesis. LPA has a plethora of biological activities on blood cells (platelets, monocytes) and cells of the vessel wall (endothelial cells, smooth muscle cells,
Andreas, Schober, Wolfgang, Siess
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Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase
Journal of Lipid Research, 2012 Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
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Lysophosphatidic Acid Signaling in Cancer [PDF]
Cancers, 2020 This Special Issue aims to highlight the impact of discoveries made over the last 25 years on the role of autotaxin (ATX) and lysophosphatidic acid (lysophosphatidate, LPA) signaling in tumor growth, metastasis and the treatment of cancers by chemotherapy, radiotherapy and immunotherapy [...]
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Effects of Pogostemon cablin on Serum Metabolomice of Guizhou Miniature Pigs and It's mechanism
Shiyan dongwu yu bijiao yixue, 2023 Objective Based on the liquid chromatography-tandem mass spectormetry (LC-MS/MS), to study the effects of Pogostemon cablin on serum metabolism of Guizhou miniature pigs， and to explore its pharmacological mechanism.
LU Taofeng +5 more
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One lipid, two synaptic plasticity pathways. [PDF]
PLoS Biology, 2015 A new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both excitatory and inhibitory synapses in the brain, but by different mechanisms. Read the accompanying Research Article.
Richard Robinson
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Lysophosphatidic acid synthesis and release [PDF]
Prostaglandins & Other Lipid Mediators, 2001 Lysophosphatidic acid (LPA) is a bioactive phospholipid controlling numerous cellular responses through the activation of specific G-protein coupled transmembrane receptors. LPA is present in several biological fluids (serum, plasma, aqueous humor) and can be secreted by several cell types (platelets, fibroblasts, adipocytes, cancer cells).
Pagès, Céline +3 more
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A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification
Journal of Lipid Research, 2000 The objective of the present work was to develop a simple and sensitive radioenzymatic assay to quantify lysophosphatidic acid (LPA). For that, a recombinant rat LPA acid acyltransferase (LPAAT) produced in Escherichia coli was used.
Jean Sébastien Saulnier-Blache +4 more
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