Results 21 to 30 of about 2,548,802 (177)

LPAR1 (lysophosphatidic acid receptor 1) [PDF]

, 2010
Review on LPAR1 (lysophosphatidic acid receptor 1), with data on DNA, on the protein encoded, and where the gene is ...
Radhakrishna, H, Murph, MM, H Radhakrishna, MM Murph   +3 more
core   +1 more source

Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion

Frontiers in Immunology, 2023
Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR).
Anne-Claire Duchez, Anne-Claire Duchez, Sébastien Fauteux-Daniel, Sébastien Fauteux-Daniel, Caroline Sut, Theo Ebermeyer, Marco Heestermans, Marco Heestermans, Charles-Antoine Arthaud, Charles-Antoine Arthaud, Marie-Ange Eyraud, Marie-Ange Eyraud, Amélie Prier, Amélie Prier, Estelle Audoux, Estelle Audoux, Justine Bertrand-Michel, Justine Bertrand-Michel, Bernard Payrastre, Bernard Payrastre, Olivier Garraud, Eric Boilard, Eric Boilard, Hind Hamzeh-Cognasse, Fabrice Cognasse, Fabrice Cognasse   +25 more
doaj   +1 more source

Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X receptor-mediated bone cancer pain in rats

Molecular Pain, 2016
Background Lysophosphatidic acid receptor 1 and Rho/ROCK signaling is implicated in bone cancer pain development. However, it remains unknown whether the two signaling pathways function together in P2X 3 receptor-mediated bone cancer pain.
Jing-xiang Wu MD, Xiao-min Yuan MMed, Qiong Wang MMed, Wang Wei MM (cand), Mei-ying Xu MBBS   +4 more
doaj   +1 more source

Effects of Pogostemon cablin on Serum Metabolomice of Guizhou Miniature Pigs and It's mechanism

Shiyan dongwu yu bijiao yixue, 2023
Objective Based on the liquid chromatography-tandem mass spectormetry (LC-MS/MS), to study the effects of Pogostemon cablin on serum metabolism of Guizhou miniature pigs， and to explore its pharmacological mechanism.
LU Taofeng, ZHANG Hui, ZHOU Jie, LI Qian, WU Shuguang, WU Yanjun   +5 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

Nature Communications, 2016
Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as ...
Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P. Joosten, Manjula Sunkara, Andrew J. Morris, Elisa Matas-Rico, Wouter H. Moolenaar, Ronald P. Oude Elferink, Anastassis Perrakis   +12 more
doaj   +1 more source

Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling

, 2021
Curcumin is a natural compound that has been widely used as a food additive and medicine in Asian countries. Over several decades, diverse biological effects of curcumin have been elucidated, such as anti-inflammatory and anti-oxidative activities ...
Kamato, Danielle, Xu, Suowen, Suowen Xu, Little, Peter J, Zhou, Ying, Peter J. Little, Danielle Kamato, Ying Zhou   +7 more
core   +1 more source

Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase

Journal of Lipid Research, 2012
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
doaj   +1 more source

One lipid, two synaptic plasticity pathways. [PDF]

PLoS Biology, 2015
A new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both excitatory and inhibitory synapses in the brain, but by different mechanisms. Read the accompanying Research Article.
Richard Robinson
doaj   +1 more source

Lysophosphatidic Acid Receptor Antagonists and Cancer: The Current Trends, Clinical Implications, and Trials

Cells, 2021
Lysophosphatidic acid (LPA) is a bioactive lipid mediator primarily derived from membrane phospholipids. LPA initiates cellular effects upon binding to a family of G protein-coupled receptors, termed LPA receptors (LPAR1 to LPAR6).
Yu-Hsuan Lin, Yueh-Chien Lin, Chien-Chin Chen   +2 more
doaj   +1 more source