Results 31 to 40 of about 2,548,802 (177)

Lysophosphatidic Acid and Glutamatergic Transmission

Frontiers in Molecular Neuroscience, 2019
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in neurons and glial cells by affecting
Carolina Roza, José A. Campos-Sandoval, María C. Gómez-García, Ana Peñalver, Javier Márquez   +4 more
doaj   +1 more source

Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis

BMC Women's Health, 2017
Background Given the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the development of ...
Bicheng Yang, Liqun Wang, Xiaoju Wan, Yunjun Li, Xiaohong Yu, Yunna Qin, Yong Luo, Feng Wang, Ouping Huang   +8 more
doaj   +1 more source

Angiogenic effect of lysophosphatidic acid receptors on cervical cancer cells

, 2017
Cervical cancer was recently reported to be the fourth leading cause of cancer death in women worldwide, causing an estimated 265,700 deaths a year.
Chen, Ruey-Jien;Chou, Chia-Hung;Chen, Shee-Uan;Lee, Hsinyu, 陳思原;陳瑞堅   +1 more
core   +1 more source

Lysophosphatidic Acid Signaling in Cancer

, 2020
This Special Issue aims to highlight the impact of discoveries made over the last 25 years on the role of autotaxin (ATX) and lysophosphatidic acid (lysophosphatidate, LPA) signaling in tumor growth, metastasis and the treatment of cancers by ...
David N. Brindley
core   +1 more source

AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway

Nature Communications, 2021
AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids.
Hoi Yin Mak, Qian Ouyang, Sergey Tumanov, Jiesi Xu, Ping Rong, Feitong Dong, Sin Man Lam, Xiaowei Wang, Ivan Lukmantara, Ximing Du, Mingming Gao, Andrew J. Brown, Xin Gong, Guanghou Shui, Roland Stocker, Xun Huang, Shuai Chen, Hongyuan Yang   +17 more
doaj   +1 more source

Understanding the Mechanism of Action of NAI-112, a Lanthipeptide with Potent Antinociceptive Activity

Molecules, 2021
NAI-112, a glycosylated, labionine-containing lanthipeptide with weak antibacterial activity, has demonstrated analgesic activity in relevant mouse models of nociceptive and neuropathic pain.
Arianna Tocchetti, Marianna Iorio, Zeeshan Hamid, Andrea Armirotti, Angelo Reggiani, Stefano Donadio   +5 more
doaj   +1 more source

A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification

Journal of Lipid Research, 2000
The objective of the present work was to develop a simple and sensitive radioenzymatic assay to quantify lysophosphatidic acid (LPA). For that, a recombinant rat LPA acid acyltransferase (LPAAT) produced in Escherichia coli was used.
Jean Sébastien Saulnier-Blache, Alexia Girard, Marie-Françoise Simon, Max Lafontan, Philippe Valet   +4 more
doaj   +1 more source

Role of autotaxin in systemic lupus erythematosus

Frontiers in Medicine, 2023
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease characterized by the production of various autoantibodies and deposition of immune complexes.
Yumi Tsuchida, Hirofumi Shoda, Tetsuji Sawada, Keishi Fujio   +3 more
doaj   +1 more source

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization.

, 2016
Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs.
Ebener, Simone, Roberts, Jesse D, Kühnel, Mark, Chun, Jerold, Matthieu, Stephanie, Franklin, Alicia, Funke, Manuela, Ochs, Matthias, Probst, Clemens K, Fontaine, Benjamin A, Kellner, Manuela, Knudsen, Lars, Tager, Andrew M, Grothausmann, Roman, Lagares, David   +14 more
core   +1 more source

Lipoprotein(a)-Associated Molecules Are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis

JACC: Basic to Translational Science, 2017
Summary: The LPA gene is the only monogenetic risk factor for calcific aortic valve stenosis (CAVS). Oxidized phospholipids (OxPL) and lysophosphatidic acid generated by autotaxin (ATX) from OxPL are pro-inflammatory.
Michael Torzewski, MD, Amir Ravandi, MD, PhD, Calvin Yeang, MD, PhD, Andrea Edel, PhD, Rahul Bhindi, MD, Stefan Kath, MD, Laura Twardowski, MD, Jens Schmid, PhD, Xiaohong Yang, BS, Ulrich F.W. Franke, MD, Joseph L. Witztum, MD, Sotirios Tsimikas, MD   +11 more
doaj   +1 more source