Results 51 to 60 of about 2,548,802 (177)

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Untethered Electrical Stimulation Using Optoelectricity and Piezoelectricity for Tissue Regeneration

FlexTech, EarlyView.
Untethered electrical stimulation from optoelectronic and piezoelectric materials can aid regeneration of damaged tissue. ABSTRACT Electrical signals are increasingly recognized as important regulators of tissue development and regeneration, with outcomes linked to behaviors including proliferation, differentiation, cell migration, and more.
Ryan Yao, Baochun Xu, Cunjiang Yu
wiley   +1 more source

Cellular expression and subcellular localization of autotaxin, a lysophosphatidic acid-generating enzyme, in the adult and developing mouse brain

Neuroscience Research
Autotaxin (ATX) is a lysophosphatidic acid-producing enzyme. In this study, we describe the cellular expression and subcellular localization of ATX in the mouse brain, thereby providing a fundamental framework for understanding lysophosphatidic acid ...
Masanori Tachikawa, Masahiro Fukaya, Eriko Miura, Zhengyu Zhang, Shinichi Okudaira, Chihiro Takasaki, Ken-ichi Hosoya, Junken Aoki, Masahiko Watanabe   +8 more
doaj   +1 more source

Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

Nature Communications, 2016
CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is ...
Alessandro Pagliuso, Carmen Valente, Lucia Laura Giordano, Angela Filograna, Guiling Li, Diego Circolo, Gabriele Turacchio, Vincenzo Manuel Marzullo, Luigi Mandrich, Mikhail A. Zhukovsky, Fabio Formiggini, Roman S. Polishchuk, Daniela Corda, Alberto Luini   +13 more
doaj   +1 more source

LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis

Nature Communications, 2021
Dynamic assembly and disassembly of primary cilia is critical for tissue development and homeostasis. Here the authors identify lysophosphatidic acid (LPA) as a physiological extracellular factor that initiates cilia disassembly through both YAP/TAZ ...
Huai-Bin Hu, Zeng-Qing Song, Guang-Ping Song, Sen Li, Hai-Qing Tu, Min Wu, Yu-Cheng Zhang, Jin-Feng Yuan, Ting-Ting Li, Pei-Yao Li, Yu-Ling Xu, Xiao-Lin Shen, Qiu-Ying Han, Ai-Ling Li, Tao Zhou, Jerold Chun, Xue-Min Zhang, Hui-Yan Li   +17 more
doaj   +1 more source

Lysophosphatidic acid stimulates rat uterine contraction in vitro

The Journal of Reproduction and Development, 2023
Lysophosphatidic acid (LPA) has been implicated in the uterine endometrial functions of implantation and decidualization; however, not much is known about its myometrial contractile function.
Satoshi NAGASHIMA, Takuma KIMURA, Ryota TERASHIMA, Makoto SUGIYAMA, Keiichiro KIZAKI, Mitsumori KAWAMINAMI, Shiro KURUSU   +6 more
doaj   +1 more source

Chronic Kidney Disease‐Associated Pruritus Is Linked to Selective Enrichment of Taurine‐Conjugated Bile Acid Subspecies

JEADV Clinical Practice, EarlyView.
Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll, Manfred Rauh, Peter Dietrich, Marcel Vetter, Jonas Schmid, Thomas Mettang, Andreas E. Kremer   +6 more
wiley   +1 more source

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. [PDF]

, 2022
Myocardial fibrosis is a key pathologic feature of hypertrophic cardiomyopathy (HCM). However, the fibrotic pathways activated by HCM-causing sarcomere protein gene mutations are poorly defined.
DeLaughter, Daniel M, Gorham, Joshua, Seidman, JG, Leinwand, L.A., Wan, W., Probst, C.K., Tager, A.M., Seidman, J. G., Adam, L.P., Probst, Clemens K, Lindberg, E.L., Hübner, Norbert, Ho, Carolyn Y, Hübner, N., Tager, Andrew M., Seidman, C.E., Wakimoto, H., Lun, Mingyue, Seidman, J.G., Montesi, Sydney B., Lindberg, Eric L, Choi, Esther Sue, Sakai, N., Patone, G., Noseda, Michela, Adam, Leonard P., Knipe, R.S., Knipe, Rachel S., Axelsson Raja, A., Noseda, M., Ho, Carolyn Y., Shea, B., Montesi, Sydney B, Montesi, S.B., Seidman, Christine E, Ho, C.Y., Conner, David A, Patone, Giannino, DeLaughter, D.M., Adam, Leonard P, Knipe, Rachel S, Conner, D.A., Choi, E.S., Tager, Andrew M, DeLaughter, Daniel M., Raja, Anna Axelsson, Reichart, Daniel, Probst, Clemens K., Shea, Barry, Lindberg, Eric L., Conner, David A., Leinwand, Leslie A., Wan, William, Wakimoto, Hiroko, Reichart, D., Gorham, J., Leinwand, Leslie A, Axelsson Raja, Anna, Seidman, Christine E., Lun, M., Huebner, Norbert, Sakai, Norihiko   +61 more
core   +1 more source

Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling

Life Science Alliance, 2023
The authors show that Δ9-trans-tetrahydrocannabinol, the main psychoactive compound in medicinal cannabis, could be considered as a therapeutic agent by inhibiting autotaxin–lysophosphatidic acid production. Autotaxin is primarily known for the formation
Mathias C Eymery, Andrew A McCarthy, Jens Hausmann   +2 more
doaj   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source