Results 41 to 50 of about 2,548,802 (177)

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling. [PDF]

PLoS ONE, 2013
Lysophosphatidic acid acyltransferase (LPAAT-β) is a phosphatidic acid (PA) generating enzyme that plays an essential role in triglyceride synthesis. However, LPAAT-β is now being studied as an important regulator of cell growth and differentiation and ...
Michelle A Blaskovich, Vimala Yendluri, Harshani R Lawrence, Nicholas J Lawrence, Saïd M Sebti, Gregory M Springett   +5 more
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

, 2011
Blockade of lysophosphatidic acid signaling provides a new strategy for treating fetal hydrocephalus.
Yun C. Yung, Marcy A. Kingsbury, Kyoko Noguchi, Jerold Chun, Tetsuji Mutoh, Ji Woong Choi, Richard R. Rivera, Mu-En Lin   +7 more
core   +1 more source

Revisiting Securidaca longipedunculata Seed Oil: Applying NMR and Mass Spectroscopy to Confirm the Presence of 2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols and Conjugated Hydroxydienoic Fatty Acids

Journal of the American Oil Chemists' Society, EarlyView.
The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith, Jianfeng Zhu, Jin‐Yue Sun   +2 more
wiley   +1 more source

MicroRNA Regulation of the Autotaxin-Lysophosphatidic Acid Signaling Axis

, 2019
The revelation that microRNAs (miRNAs) exist within the human genome uncovered an underappreciated mechanism of gene expression. For cells to regulate expression of their genes, miRNA molecules and argonaute proteins bind to mRNAs and interfere with ...
Mandi M. Murph
core   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Supplementary Figure from Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer

, 2022
Supplementary Figure from Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian ...
Dmitriy Zamarin (14955513), David Pépin (196209), Julia Casado (15111923), Kevin Holcomb (15119620), Paolo Giovanelli (15119596), E. Alfonso Romero-Sandoval (15119623), Eun Sil Park (2722105), Chen Tan (651657), Vidyanath Chaudhary (15119608), Minkyung Song (15119614), Alexander Emmanuelli (15119605), Chang-Suk Chae (15119587), Franck J. Barrat (15119617), Juan R. Cubillos-Ruiz (15119626), Anniina Färkkilä (14948278), Sung-Min Hwang (15119593), Camilla Salvagno (15119602), Andrew V. Kossenkov (15119611), Tito A. Sandoval (15119590), Deepika Awasthi (15119599), Alan D. D'Andrea (14948314)   +20 more
core   +1 more source

Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry[S]

Journal of Lipid Research, 2010
LC/ESI-MS/MS has been previously demonstrated to be a powerful method to detect and quantify molecular species of glycerophospholipids including lysophospholipids.
James G. Bollinger, Hiromi Ii, Martin Sadilek, Michael H. Gelb   +3 more
doaj   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source