Results 11 to 20 of about 2,548,802 (177)

PrLPAAT4, a Putative Lysophosphatidic Acid Acyltransferase from Paeonia rockii, Plays an Important Role in Seed Fatty Acid Biosynthesis

Molecules, 2017
Lysophosphatidic acid acyltransferases (LPAATs) are essential for the acylation of lysophosphatidic acid (LPA) and the synthesis of phosphatidic acid (PA), a key intermediate in the synthesis of membrane phospholipids and storage lipids. Here, a putative
Qingyu Zhang, Rui Yu, Daoyang Sun, Zhangzhen Bai, Hong Li, Liang Xue, Yanlong Zhang, Lixin Niu   +7 more
doaj   +2 more sources

A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension.

PLoS ONE, 2014
Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted enzyme that has lysophospholipase D activity, which converts lysophosphatidylcholine to bioactive lysophosphatidic acid. Lysophosphatidic acid activates at
Hiroshi Saga, Akira Ohhata, Akio Hayashi, Makoto Katoh, Tatsuo Maeda, Hirotaka Mizuno, Yuka Takada, Yuka Komichi, Hiroto Ota, Naoya Matsumura, Masami Shibaya, Tetsuya Sugiyama, Shinji Nakade, Katsuya Kishikawa   +13 more
doaj   +2 more sources

Lysophosphatidic acid 2 alleviates deep vein thrombosis via protective endothelial barrier function

Open Medicine
The specific role of lysophosphatidic acid 2 (LPA2) in deep vein thrombosis (DVT) remains unclear.
Bai Ruifeng, Yue Xinyang, Tian Xuan, Zhao Huiru, Liu Ying, Li Tian, Wu Jun   +6 more
doaj   +2 more sources

Optical Control of Lysophosphatidic Acid Signaling [PDF]

, 2020
Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and activates the family of lysophosphatidic acid receptors (LPA1-6).
Citir, Mevlut, Parrill, Abby L, Morstein, Johannes, Donthamsetti, Prashant C, Trauner, Dirk, Schultz, Carsten, Isacoff, Ehud Y, Shemet, Andrej, Tigyi, Gabor J, Norman, Derek D, Dacheux, Mélanie A, Frank, James A   +11 more
core   +2 more sources

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Wolfgang Siess, Siess, Wolfgang
core   +1 more source

Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis

Frontiers in Cellular Neuroscience, 2021
Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA1–6).
Maria Puigdomenech-Poch, Maria Puigdomenech-Poch, Anna Martínez-Muriana, Pol Andrés-Benito, Pol Andrés-Benito, Isidre Ferrer, Isidre Ferrer, Jerold Chun, Rubèn López-Vales, Rubèn López-Vales   +9 more
doaj   +1 more source

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
Gabriela Kalna (192504), William J. Faller (644356), Bennett, DC, Knecht, D, Veltman, DM, Jones, R, Andrew J Muinonen-Martin, Muinonen-Martin, Andrew J, Muinonen-Martin, AJ, Lindsay, C, Faller, William J., Douwe M Veltman, Wakelam, Michael J.O., Dorothy C Bennett, David A Knecht, Owen J Sansom, Zhang, Qifeng, Faller, WJ, Michael J O Wakelam, Machesky, Laura M, Bennett, Dorothy C., Knecht, David A, Robert Jones (270787), Gabriela Kalna, Knecht, DA, Insall, Robert H, Machesky, Laura M., Smethurst, Elizabeth, Smethurst, E, Lindsay, Colin; id_orcid, Robert Jones, Lindsay, Colin, Insall, RH, Sansom, Owen J., Elizabeth Smethurst (644355), Faller, William J, Jones, Robert, Laura M Machesky, Knecht, David A., Robert H. Insall (220984), Sansom, Owen J, Andrew J. Muinonen-Martin (235328), Michael J. O. Wakelam (116384), Sansom, OJ, Machesky, LM, Machesky, Laura, Wakelam, Michael J O, Robert Herd, Insall, Robert H., Owen J. Sansom (192366), Douwe M. Veltman (220981), Veltman, Douwe M, Wakelam, MJ, Kalna, Gabriela, Elizabeth Smethurst, Muinonen-Martin, Andrew J., Susanto, Olivia, William J Faller, Colin Lindsay, Herd, R, Zhang, Q, Susanto, O, Robert H Insall, Qifeng Zhang (116382), Laura M. Machesky (175567), Bennett, Dorothy C, Kalna, G, Robert Herd (644358), Olivia Susanto (644354), Colin Lindsay (644357), Qifeng Zhang, Herd, Robert, Dorothy C. Bennett (234520), David A. Knecht (231111), Olivia Susanto, Veltman, Douwe M., Bennett, Dorothy   +76 more
core   +1 more source

CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase

Journal of Lipid Research, 2010
Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an α/β-hydrolase fold enzyme expressed in all vertebrates.
Gabriela Montero-Moran, Jorge M. Caviglia, Derek McMahon, Alexis Rothenberg, Vidya Subramanian, Zhi Xu, Samuel Lara-Gonzalez, Judith Storch, George M. Carman, Dawn L. Brasaemle   +9 more
doaj   +1 more source

Lysophosphatidic acid enhances stromal cell-directed angiogenesis. [PDF]

PLoS ONE, 2013
Ischemic diseases such as peripheral vascular disease (PVD) affect more than 15% of the general population and in severe cases result in ulcers, necrosis, and limb loss.
Bernard Y K Binder, Claus S Sondergaard, Jan A Nolta, J Kent Leach   +3 more
doaj   +1 more source

LPAR2 (lysophosphatidic acid receptor 2) [PDF]

, 2013
Review on LPAR2 (lysophosphatidic acid receptor 2), with data on DNA, on the protein encoded, and where the gene is ...
Georas, S, Knowlden, S
core   +1 more source