Results 11 to 20 of about 32,116 (179)
Lysophosphatidic Acid and Glutamatergic Transmission [PDF]
Frontiers in Molecular Neuroscience, 2019 Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in neurons and glial cells by affecting
Carolina Roza +4 more
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Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis [PDF]
BMC Women's Health, 2017 Background Given the important roles of the receptor-mediated lysophosphatidic acid (LPA) signaling in both reproductive tract function and gynecological cancers, it will be informative to investigate the potential role of LPA in the development of ...
Bicheng Yang +8 more
doaj +3 more sources
Reproductive Biology and Endocrinology, 2021 Background Lysophosphatidic acid-supplemented culture medium significantly increases the oocyte maturation rate in vitro. However, potential targets and pathways involved remain unknown.
Qigui Xie +5 more
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Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis
Frontiers in Cellular Neuroscience, 2021 Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA1–6).
Maria Puigdomenech-Poch +9 more
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CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase
Journal of Lipid Research, 2010 Mutations in human CGI-58/ABHD5 cause Chanarin-Dorfman syndrome (CDS), characterized by excessive storage of triacylglycerol in tissues. CGI-58 is an α/β-hydrolase fold enzyme expressed in all vertebrates.
Gabriela Montero-Moran +9 more
doaj +1 more source
Lysophosphatidic acid enhances stromal cell-directed angiogenesis. [PDF]
PLoS ONE, 2013 Ischemic diseases such as peripheral vascular disease (PVD) affect more than 15% of the general population and in severe cases result in ulcers, necrosis, and limb loss.
Bernard Y K Binder +3 more
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Lysophosphatidic acid (LPA) and angiogenesis [PDF]
Angiogenesis, 2008 Lysophosphatidic acid (LPA) is a simple lipid with many important biological functions such as the regulation of cellular proliferation, cellular migration, differentiation, and suppression of apoptosis. Although a direct angiogenic effect of LPA has not been reported to date, there are indications that LPA promotes angiogenesis.
Carol M, Rivera-Lopez +2 more
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Molecules, 2017 Lysophosphatidic acid acyltransferases (LPAATs) are essential for the acylation of lysophosphatidic acid (LPA) and the synthesis of phosphatidic acid (PA), a key intermediate in the synthesis of membrane phospholipids and storage lipids. Here, a putative
Qingyu Zhang +7 more
doaj +1 more source
PLoS ONE, 2014 Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), is a secreted enzyme that has lysophospholipase D activity, which converts lysophosphatidylcholine to bioactive lysophosphatidic acid. Lysophosphatidic acid activates at
Hiroshi Saga +13 more
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Frontiers in Immunology, 2023 Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR).
Anne-Claire Duchez +25 more
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