Results 21 to 30 of about 2,946 (161)

From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling

Molecules
2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid (EC), acting as a full agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in postsynaptic membranes through the sequential action of phosphoinositide-specific ...
Fabienne Briand-Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan, Jérôme Ausseil, Bernard Payrastre, Jean-Pierre Salles, Hugues Chap   +8 more
doaj   +1 more source

Lysophospholipid Growth Factors and Their G Protein-Coupled Receptors in Immunity, Coronary Artery Disease, and Cancer

The Scientific World Journal, 2002
The physiological lysophospholipids (LPLs), exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are omnific mediators of normal cellular proliferation, survival, and functions.
Edward J. Goetzl, Markus Graeler, Mei-Chuan Huang, Geetha Shankar   +3 more
doaj   +1 more source

Autotaxin in Pathophysiology and Pulmonary Fibrosis

Frontiers in Medicine, 2018
Lysophospholipid signaling is emerging as a druggable regulator of pathophysiological responses, and especially fibrosis, exemplified by the relative ongoing clinical trials in idiopathic pulmonary fibrosis (IPF) patients.
Ioanna Ninou, Christiana Magkrioti, Vassilis Aidinis   +2 more
doaj   +1 more source

TNF-α promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines[S]

Journal of Lipid Research, 2011
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid present in low concentrations in serum and biological fluids but in high concentrations at sites of inflammation.
Chenqi Zhao, Anne Sardella, Jerold Chun, Patrice E. Poubelle, Maria J. Fernandes, Sylvain G. Bourgoin   +5 more
doaj   +1 more source

Lysophospholipid (LPA) receptors in GtoPdb v.2021.3

IUPHAR/BPS Guide to Pharmacology CITE, 2021
Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [55, 19, 82, 129]) are activated by the endogenous phospholipid LPA. The first receptor, LPA1, was identified as ventricular zone gene-1 (vzg-1) [40], This discovery represented the beginning of the de-orphanisation of members of ...
Valerie P. Tan, Manisha Ray, Tony Ngo, Yasuyuki Kihara, Deepa Jonnalagadda, Danielle Jones, Jerold Chun, Victoria Blaho   +7 more
openaire   +4 more sources

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry[S]

Journal of Lipid Research, 2019
Lysophosphatidic acid (LPA) activates cognate G protein-coupled receptors (GPCRs) to initiate biological signaling cascades. Lysophospholipid (LP) receptor binding properties remain incompletely assessed because of difficulties with ligand lipophilicity ...
Hirotaka Mizuno, Yasuyuki Kihara, Amanda Kussrow, Allison Chen, Manisha Ray, Richard Rivera, Darryl J. Bornhop, Jerold Chun   +7 more
doaj   +1 more source

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia

Journal of Neuroinflammation, 2020
Background In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors.
Ioanna Plastira, Eva Bernhart, Lisha Joshi, Chintan N. Koyani, Heimo Strohmaier, Helga Reicher, Ernst Malle, Wolfgang Sattler   +7 more
doaj   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

Journal of Lipid Research, 2019
HDL-bound ApoM and albumin are protein chaperones for the circulating bioactive lipid, sphingosine 1-phosphate (S1P); in this role, they support essential extracellular S1P signaling functions in the vascular and immune systems. We previously showed that
Hideru Obinata, Andrew Kuo, Yukata Wada, Steven Swendeman, Catherine H. Liu, Victoria A. Blaho, Rieko Nagumo, Kenichi Satoh, Takashi Izumi, Timothy Hla   +9 more
doaj   +1 more source