Results 21 to 30 of about 3,169 (190)

Lysophospholipids and lysophospholipid receptors.

, 2023
(A) Lysophospholipids. (B) Phylogenetic tree of lysophospholipid receptors. Sequence similarity analysis of EDG family receptors, P2Y family receptors, and other lysophospholipid receptors. Multiple sequence alignment was done with MUSCLE.
Guibing Liu (16986486), Xuan Zhang (56049), Xiu Li (519849), Yujing Wang (1993366), Weimin Gong (120989)   +4 more
core   +1 more source

Lysophospholipid (S1P) receptors in GtoPdb v.2021.2

, 2021
Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid receptors [89]) are activated by the endogenous lipid sphingosine 1-phosphate (S1P). Originally cloned as orphan members of the endothelial
Blaho, Victoria, Jonnalagadda, Deepa, Chun, Jerold, Kihara, Yasuyuki, Tan, Valerie P., Jones, Danielle   +5 more
core   +1 more source

Lysophospholipid G Protein-coupled Receptors [PDF]

Journal of Biological Chemistry, 2004
The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
openaire   +2 more sources

Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development

Mediators of Inflammation, 2017
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1–6, to induce
Silvia Anahi Valdés-Rives, Aliesha González-Arenas   +1 more
doaj   +1 more source

An update on the biology of sphingosine 1-phosphate receptors

Journal of Lipid Research, 2014
Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily as an ex­tracellular signaling molecule. Signals initiated by S1P are transduced by five G protein-coupled receptors, named S1P1–5.
Victoria A. Blaho, Timothy Hla
doaj   +1 more source

Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury [PDF]

, 2010
HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated sphingophospholipids have similar effects.
Bodo Levkau, Levkau, Bodo, Herrgott, Ilka, Johanning, Kai, Echtermeyer, Frank, Chun, Jerold, Hildebrand, Reinhard, Ilka Herrgott, Gregor Theilmeier, Christine Herzog, Winterhalter, Michael, Frank Ulrich Müller, Schmitz, Martina, Müller, Frank Ulrich, Jan Mersmann, Michael Winterhalter, Reinhard Hildebrand, Martina Schmitz, Herzog, Christine, Frank Echtermeyer, Jerold Chun, Theilmeier, Gregor, Mersmann, Jan, Larmann, Jan, Jan Larmann, Kai Johanning   +25 more
core   +1 more source

A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay

Journal of Lipid Research, 2016
Sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive signaling lysophospholipids that activate specific G protein-coupled receptors on the cell surface triggering numerous biological events.
Jonathan K. Fleming, Thomas R. Glass, Steve J. Lackie, Jonathan M. Wojciak   +3 more
doaj   +1 more source

Lysophospholipids and their G protein-coupled receptors in atherosclerosis [PDF]

Frontiers in Bioscience, 2016
Lysophospholipids (LPLs) are bioactive lipid-derived signaling molecules generated by the enzymatic and chemical processes of regiospecific phospholipases on substrates such as membrane phospholipids (PLs) and sphingolipids (SLs). They play a major role as extracellular mediators by activating G-protein coupled receptors (GPCRs) and stimulating diverse
Ya-Feng, Li, Rong-Shan, Li, Sonia B, Samuel, Ramon, Cueto, Xin-Yuan, Li, Hong, Wang, Xiao-Feng, Yang   +6 more
openaire   +3 more sources

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.

PLoS ONE, 2015
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid.
Aggeliki Katsifa, Eleanna Kaffe, Nefeli Nikolaidou-Katsaridou, Aris N Economides, Susan Newbigging, Colin McKerlie, Vassilis Aidinis   +6 more
doaj   +1 more source

Opposing Roles of S1P₃ Receptors in Myocardial Function

Cells, 2020
Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1–5 receptors. Whereas S1P was shown to protect the heart against ischemia/reperfusion (I/R) injury, other studies highlighted its ...
Dina Wafa, Nóra Koch, Janka Kovács, Margit Kerék, Richard L. Proia, Gábor J. Tigyi, Zoltán Benyó, Zsuzsanna Miklós   +7 more
doaj   +1 more source