Results 41 to 50 of about 2,946 (161)

Lysophospholipid receptors LPA1–3 are not required for the inhibitory effects of LPA on mouse retinal growth cones

Eye and Brain, 2010
Eric Birgbauer, Jerold ChunDepartment of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA, USA Abstract: One of the major requirements in the development of the visual ...
Eric Birgbauer, Jerold Chun
doaj  

Autocrine/paracrine lysophosphatidylserine signaling suppresses B cell aggregation and tertiary lymphoid structure formation

iScience
Summary: Accumulating evidence suggests that Gα13 signaling by G protein-coupled receptors negatively regulate B cell function. We report here that lysophosphatidylserine (LysoPS), an emerging immunoregulatory lysophospholipid, is produced upon B cell ...
Akiharu Uwamizu, Yuji Shinjo, Jumpei Omi, Manae Tatstumi, Kuniyuki Kano, Kumiko Makide, Hajime Kitamura, Michiyo Okudaira, Keita Satoh, Fumiya Fukami, Tasuku Kawano, Tomomitsu Miyasaka, Tomoko Takahashi, Osamu Nakajima, Tomohiko Ohwada, Asuka Inoue, Junken Aoki   +16 more
doaj   +1 more source

Hepatic uptake of chylomicron remnants

Journal of Lipid Research, 1997
Chylomicrons are formed in the intestine and transport dietary triglyceride to peripheral tissues and cholesterol to the liver. The enzyme lipoprotein lipase, with apolipoprotein (apo)C-II as a co-factor, hydrolyzes chylomicron triglyceride allowing the ...
A D Cooper
doaj   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Sphingosine 1-Phosphate Receptor 1 as a Useful Target for Treatment of Multiple Sclerosis

Pharmaceuticals, 2012
Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, is generated from sphingosine by sphingosine kinases and binds five known cell surface receptors.
Kunitomo Adachi, Kenji Chiba
doaj   +1 more source

Hyperactivation and Tyrosine Phosphorylation of Cryopreserved Stallion Spermatozoa in Relation to Conventional In Vitro Fertilization Blastocyst Production

Andrology, EarlyView.
ABSTRACT Background Challenges in establishing clinical conventional in vitro fertilization (IVF) in horses include variation in sperm and oocyte quality, which can be affected by mare age. Extended preincubation of stallion spermatozoa has resulted in successful IVF.
Raul A. Gonzalez‐Castro, Carolina C. Porflidt, Alexandra L. Ash, Jacobo S. Rodriguez, Perla D. Fleury, Edward L. Squires, Elaine M. Carnevale   +6 more
wiley   +1 more source

Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid[S]

Journal of Lipid Research, 2013
We previously reported that lysophosphatidic acid (LPA) inhibits the neuronal differentiation of human embryonic stem cells (hESC). We extended these studies by analyzing LPA舗s effects on the expansion of neural stem/progenitor cells (NS/PC) derived from
Frisca Frisca, Duncan E. Crombie, Mirella Dottori, Yona Goldshmit, Alice Pébay   +4 more
doaj   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Lysophospholipid Receptor-Mediated Calcium Signaling in Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2008
The lysophospholipids, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), stimulate chemotaxis and induce differentiation of human keratinocytes. As Ca(2+) plays an important role in keratinocyte differentiation, we studied Ca(2+) signaling by S1P and LPA in these cells, known to express mRNA transcripts of the S1P(1-5) and LPA(1-3 ...
Lichte, Karin, Rossi, Roberto, Danneberg, Kerstin, Braak, Michael ter, Kürschner, Ulrich, Jakobs, Karl H., Kleuser, Burkhard, Heringdorf, Dagmar Meyer zu   +7 more
openaire   +2 more sources

Lysophospholipid (S1P) receptors in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE, 2023
Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid receptors [96]) are activated by the endogenous lipid sphingosine 1-phosphate (S1P). Originally cloned as orphan members of the endothelial differentiation gene (edg) family [16, 123], the receptors are currently designated as S1P1R ...
Yasuyuki Kihara, Deepa Jonnalagadda, Danielle Jones, Deron Herr, Jerold Chun, Victoria Blaho   +5 more
openaire   +1 more source