Results 141 to 150 of about 327,382 (312)

The role of sphingosine‐1‐phosphate in inflammation and cancer progression

Cancer Science, 2018
Many inflammatory mediators are involved in the process of carcinogenesis and cancer progression. In addition to cytokines and chemokines, lipid mediators have recently attracted attention as signaling molecules associated with inflammatory diseases ...
M. Nagahashi, M. Abe, K. Sakimura, K. Takabe, T. Wakai   +4 more
semanticscholar   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib

Current Research in Pharmacology and Drug Discovery
Non-small-cell lung cancer (NSCLC) represents a predominant histological subtype of lung cancer, characterized by high incidence and mortality rates.
Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan   +6 more
doaj   +1 more source

Blockage of sphingosine‐1‐phosphate receptor 2 attenuates allergic asthma in mice

British Journal of Pharmacology, 2019
Sphingosine‐1‐phosphate 2 (S1P2) receptors have been implicated in degranulation of mast cells. However, functions of S1P2 receptors have not been investigated in an in vivo model of allergic asthma.
Soojin Park, D. Im
semanticscholar   +1 more source

Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy

International Journal of Cosmetic Science, EarlyView.
Abstract Objectives Oat lipids are rich in ceramides. In this investigation, we analysed the delivery of a specific Oat Lipid Extract derived from Avena sativa, comprising ‘skin identical’ ratios of fatty acids, ceramides and cholesterol/sterol. This investigation is the first reported investigation of oat lipids utilizing Raman spectroscopy for the ...
E. Gombert, C. Dewis
wiley   +1 more source

Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.

PLoS ONE, 2014
Sphingosine-1-phosphate (S1P) is an agonist for five distinct G-protein coupled receptors, that is released by platelets, mast cells, erythrocytes and endothelial cells.
Kathinka W E M van Hooren, Léon J A Spijkers, Dorothee van Breevoort, Mar Fernandez-Borja, Ruben Bierings, Jaap D van Buul, Astrid E Alewijnse, Stephan L M Peters, Jan Voorberg   +8 more
doaj   +1 more source

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]

, 2019
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G, Gray, Elizabeth E, Laidlaw, Brian J, Ramírez-Valle, Francisco, Zhang, Yang   +4 more
core   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.

Journal of Lipid Research, 1989
A procedure is described to prepare sphingosine-1-phosphate by treatment of sphingosylphosphocholine with phospholipase D, isolated from Streptomyces chromofuscus.
P P Van Veldhoven, R J Foglesong, R M Bell   +2 more
doaj   +1 more source

The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering [PDF]

, 1999
Eva E. Prieschl, Robert Csonga, V. Novotny, Gary E. Kikuchi, Thomas Baumruker   +4 more
openalex   +1 more source