Results 101 to 110 of about 327,382 (312)

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. [PDF]

, 2009
The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the ...
Cyster, Jason G, Grigorova, Irina L, Okada, Takaharu, Pham, Trung HM, Phan, Tri Giang, Schwab, Susan R   +5 more
core  

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Does Siponimod Exert Direct Effects in the Central Nervous System?

Cells, 2020
The modulation of the sphingosine 1-phosphate receptor is an approved treatment for relapsing multiple sclerosis because of its anti-inflammatory effect of retaining lymphocytes in lymph nodes.
Markus Kipp
doaj   +1 more source

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]

, 2018
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I., Macleod, Megan K.L., Westerhof, Lotus   +2 more
core   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, EarlyView.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

Sphingosine 1 phosphate production is an important mediator of skin inflammation and host defense in hyperglycemic mice [PDF]

, 2023
Ana Carolina Guerta Salina, Leticia Aquino Penteado, Amondrea Blackman, C. Henrique Serezani   +3 more
openalex   +1 more source

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

The emerging role of FTY720 (Fingolimod) in cancer treatment [PDF]

, 2016
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-phosphate 1 receptor.
Abdollahi, Alewijnse, Alexander, Aradhye, Arai, Arlinghaus, Bae, Baumruker, Baxter, Ben-Sasson, Bohler, Bollen, Braun, Brinkmann, Broek, Brune, Brune, Bueno, Bueno, Bueno, Burtin, Byrd, Cabot, Campochiaro, Chauhan, Chen, Chiba, Curino, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cyster, Cyster, Edwards, Eshhar, Fan, Fan, Fan, Fan, Ferrer, Gajewski, Garcia, Garcia-Foncillas, Garcia-Foncillas, Geilen, Grech, Greten, Habib, Hahn, Hakomori, Hakomori, Hakomori, Han, Han, Hanessian, Hannun, Hannun, He, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hoshino, Huang, Huwiler, Huwiler, Huwiler, Huyton, Ibrahim, Igarashi, Igarashi, Igarashi, Jaffrezou, Kappos, Karliner, Karliner, Kasahara, Katsuoka, Katsuoka, Katsuoka, Kaufmann, Klostergaard, Kohama, Kordula, Kornblau, Lee, Lee, Lei, Lei, Li, Liao, Lichter, Liu, Liu, Liu, Lynch, Lynch, Lynch, Macdonald, Marcucci, Masood, Matsuyama, May, May, Moolenaar, Morisaki, Mosser, Muthusamy, Muthusamy, Muthusamy, Nakamura, Neviani, Neviani, Nozawa, Nozawa, Nussbaumer, Obeid, Obeid, Obeid, Obeid, Oberlies, Odero, Ogretmen, Ohdan, Okumoto, Okuyama, Park, Pchejetski, Pchejetski, Phelps, Pitson, Pitson, Pitson, Pollard, Prior, Proia, Proia, Pyne, Pyne, Pyne, Pyne, Pyne, Pyne, Rader, Radue, Rennard, Rodrigues, Rosen, Rosen, Roy, Ruefli-Brasse, Sabbadini, Sakaguchi, Sanchez, Satoh, Schmouder, Schwartz, Seishima, Sharma, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Smith, Smith, Song, Song, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Stracke, Stracke, Stracke, Sun, Suzuki, Suzuki, Tagliaferri, Tagliaferri, Takahara, Takuwa, Takuwa, Taniwaki, Tornquist, Troncone, Uesato, Vadas, Vadas, Vadas, Vadas, Verrills, Walsh, Wang, Wang, Wattenberg, Wattenberg, Waxman, Weichselbaum, Wiedermann, Wolf, Wong, Wong, Wood, Woodcock, Wu, Xia, Xia, Xia, Xia, Xu, Xu, Yap, Yee, Yun, Yun, Zangemeister-Wittke, Zawadzke, Zheng, Zheng   +249 more
core   +2 more sources

New insights into functions of the sphingosine-1-phosphate transporter SPNS2

Journal of Lipid Research, 2019
Sphingosine-1-phosphate (S1P) is a potent bioactive signaling molecule that regulates many physiological processes important for development, epithelial and endothelial barrier integrity, and the immune system, as well as for pathologies, such as ...
S. Spiegel, Melissa A. Maczis, Michael Maceyka, S. Milstien   +3 more
semanticscholar   +1 more source