Results 11 to 20 of about 327,382 (312)

Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface

Biology, 2022
Sphingosine 1-phosphate (S1P) is a product of membrane sphingolipid metabolism. S1P is secreted and acts via G-protein-coupled receptors, S1PR1-5, and is involved in diverse cellular functions, including cell proliferation, immune suppression, and ...
Kana Masuda-Kuroki, Anna Di Nardo
doaj   +2 more sources

Sphingosine 1-phosphate and inflammation [PDF]

International Immunology, 2019
AbstractAbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P receptor signaling system plays important roles in lymphocyte trafficking and maintenance of vascular integrity, thus contributing to the regulation of complex inflammatory ...
Hideru, Obinata, Timothy, Hla
openaire   +3 more sources

Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases

Frontiers in Pharmacology, 2019
The central nervous system is characterized by a high content of sphingolipids and by a high diversity in terms of different structures. Stage- and cell-specific sphingolipid metabolism and expression are crucial for brain development and maintenance ...
Sara Grassi, Laura Mauri, Simona Prioni, Livia Cabitta, Sandro Sonnino, Alessandro Prinetti, Paola Giussani   +6 more
doaj   +2 more sources

Sphingosine 1-phosphate and cancer [PDF]

Advances in Biological Regulation, 2018
The bioactive lipid, sphingosine 1-phosphate (S1P) is produced by phosphorylation of sphingosine and this is catalysed by two sphingosine kinase isoforms (SK1 and SK2). Here we discuss structural functional aspects of SK1 (which is a dimeric quaternary enzyme) that relate to coordinated coupling of membrane association with phosphorylation of Ser225 in
Nigel J. Pyne, Ashref El Buri, David R. Adams, Susan Pyne   +3 more
openaire   +4 more sources

Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks

Cells, 2020
As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer ...
Laura Riboni, Loubna Abdel Hadi, Stefania Elena Navone, Laura Guarnaccia, Rolando Campanella, Giovanni Marfia   +5 more
doaj   +2 more sources

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate [PDF]

Cell, 1999
Menq-Jer Lee, Timothy T Hla, Kevin P Claffey   +2 more
exaly   +2 more sources

Sphingosine 1-Phosphate [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Sphingosine-1-phosphate receptor 2 inhibition ameliorates familial exudative vitreoretinopathy models. [PDF]

J Biol Chem
Feridooni HA, Fody R, Tavasoli M, Alkandari M, van der Ende S, Nader M, Robitaille JM, McMaster CR.   +7 more
europepmc   +3 more sources

Sphingosine-1-phosphate [PDF]

Circulation Research, 2006
See related article, pages 731–739 A key question in unlocking the mystery of accelerated atherosclerosis that often accompanies types1 and 2 diabetes and leads to increased incidence and severity of heart attacks and strokes is, what are the precise biochemical and molecular signaling pathways that perturb the diabetic blood vessel leading to ...
Ravichandran Ramasamy, Shi Fang Yan, Ann Marie Schmidt   +2 more
  +5 more sources

Sphingosine 1-phosphate [PDF]

British Journal of Pharmacology, 2009
Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell
G, Daum, A, Grabski, M A, Reidy
  +6 more sources