Results 11 to 20 of about 37,566 (200)
Sphingosine 1-Phosphate in Renal Diseases [PDF]
Cellular Physiology and Biochemistry, 2013 Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Alexander Koch +2 more
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Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate
iScienceSummary: Benign prostatic hyperplasia (BPH) is a common condition in aging males, but its underlying pathogenesis remains unclear. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) play important roles in various diseases, while less studied in ...
Daoquan Liu +12 more
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Sphingosine 1-phosphate and cancer [PDF]
Nature Reviews Cancer, 2010 There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival.
Pyne, N.J., Pyne, S.
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2009 Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell
G, Daum, A, Grabski, M A, Reidy
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Circulation Research, 2006 See related article, pages 731–739 A key question in unlocking the mystery of accelerated atherosclerosis that often accompanies types1 and 2 diabetes and leads to increased incidence and severity of heart attacks and strokes is, what are the precise biochemical and molecular signaling pathways that perturb the diabetic blood vessel leading to ...
Ravichandran Ramasamy +2 more
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Sphingosine 1-phosphate and inflammation [PDF]
International Immunology, 2019 AbstractAbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P receptor signaling system plays important roles in lymphocyte trafficking and maintenance of vascular integrity, thus contributing to the regulation of complex inflammatory ...
Hideru, Obinata, Timothy, Hla
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Sphingosine 1-phosphate signalling [PDF]
Development, 2014 Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival.
Karen, Mendelson +2 more
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Sphingosine 1-Phosphate and Atherosclerosis
Journal of Atherosclerosis and Thrombosis, 2018 Sphingosine 1-phosphate (S1P) is a potent lipid mediator that works on five kinds of S1P receptors located on the cell membrane. In the circulation, S1P is distributed to HDL, followed by albumin. Since S1P and HDL share several bioactivities, S1P is believed to be responsible for the pleiotropic effects of HDL.
Kurano, Makoto, Yatomi, Yutaka
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The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications
Tumor Biology, 2017 Elucidating the interaction between cancer and non-cancer cells, such as blood vessels, immune cells, and other stromal cells, in the tumor microenvironment is imperative in understanding the mechanisms underlying cancer progression and metastasis, which
Masato Nakajima +4 more
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Frontiers in Physiology, 2018 Platelets affect myocardial damage from ischemia/reperfusion. Redox-dependent sphingosine-1-phosphate production and release are altered in diabetic platelets. Sphingosine-1-phosphate is a double-edged sword for ischemia/reperfusion injury. Therefore, we
Isabella Russo +12 more
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