Results 11 to 20 of about 21,457,228 (260)

Roles of sphingosine 1-phosphate on tumorigenesis [PDF]

World Journal of Biological Chemistry, 2011
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with a variety of biological activities. It is generated from the conversion of ceramide to sphingosine by ceramidase and the subsequent conversion of sphingosine to S1P, which is catalyzed by sphingosine kinases. Through increasing its intracellular levels by sphingolipid metabolism and binding
Huang, Y.-L., Huang, W.-P., Lee, H.
openaire   +4 more sources

Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis

Indian Journal of Ophthalmology, 2012
Background: Apoptosis is a programmed cell death in multicellular organisms, found in a wide variety of conditions, including inflammatory process, everywhere in the body, including the cornea and conjunctiva. Aim: To evaluate the effect of a new topical
Pierre Fournie, Stéphane Galiacy, Marie-Laure Ranty, Isabelle Rico-Lattes, François Malecaze, Jean-Claude Quintyn   +5 more
doaj   +2 more sources

Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. [PDF]

PLoS ONE, 2011
Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Reza Soleimani, Elke Heytens, Kutluk Oktay   +2 more
doaj   +1 more source

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

ESC Heart Failure, 2023
Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin, Lisa Dannenberg, Marcel Benkhoff, Maike Barcik, Petra Keul, Aysel Ayhan, Sarah Weske, Samantha Ahlbrecht, Kajetan Trojovsky, Carolin Helten, Sebastian Haberkorn, Ulrich Flögel, Tobias Zeus, Tina Müller, Markus H. Gräler, Malte Kelm, Bodo Levkau   +16 more
doaj   +1 more source

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer

Discover Oncology, 2021
Sphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (
Guangmeng Xu, Zecheng Yang, Yamin Sun, Hongmei Dong, Jingru Ma   +4 more
doaj   +1 more source

The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives

Cells, 2020
Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena.
Alexandra Lucaciu, Robert Brunkhorst, Josef M. Pfeilschifter, Waltraud Pfeilschifter, Julien Subburayalu   +4 more
doaj   +1 more source

Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface

Biology, 2022
Sphingosine 1-phosphate (S1P) is a product of membrane sphingolipid metabolism. S1P is secreted and acts via G-protein-coupled receptors, S1PR1-5, and is involved in diverse cellular functions, including cell proliferation, immune suppression, and ...
Kana Masuda-Kuroki, Anna Di Nardo
doaj   +1 more source

Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations [PDF]

, 2021
Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is a fundamental pathogenic process associated with malplacentation and the development of preeclampsia.
Yue Wu (1262184), Mingyu Hu (2177308), Li Lin (111038), Louise C Kenny (10123735), Mark D Kilby (8483634), Jiayu Huang (3408389), Chao Tong (389167), Huijia Fu (8719995), Li Wen (169316), Yangxi Zheng (8654490), Philip N Baker (7724603), Hongbo Qi (1370292), Biao Huang (215504), Sisi Li (437128), Xuan Ye (1817743), Yong Fu (699744), Jiujiang Liao (8654865), Ping Xu (122619), Ran Duan (821258), Xiyao Liu (5736281)   +19 more
core   +2 more sources

Elevated sphingosine-1-phosphate lyase leads to increased metabolism and reduced survival in adrenocortical carcinoma [PDF]

, 2023
Adrenocortical carcinomas (ACCs) are invasive tumours arising in the adrenal cortex, and steroidogenic tumours are associated with worse prognostic outcomes.
Laila Parvanta, Charlotte Hall, Ruth Kwong, Williams, Jack L., Smith, C, Palazzo, Fausto, Abdel-Aziz, TE, Josefina Casas, Parvanta, Laila, Prasad, Rathi, Metherell, Lou, Pittaway, J, Kwong, Ruth, Fausto Palazzo, Avinaash Maharaj, Parvanta, L, Hall, Charlotte, Chung, Teng-Teng, Abdel-Aziz, Tarek Ezzat, Prasad, R, Tarek Ezzat Abdel-Aziz, Lou Metherell, Smith, Chris, Chung, T-T, Kwong, R, Teng-Teng Chung, Chris Smith, Rathi Prasad, Williams, JL, Leonardo Guasti, Guasti, Leonardo, Guasti, L, Jack L Williams, Maharaj, Avinaash, Khaled, Z, Maharaj, A, Pittaway, James, James Pittaway, Casas, Josefina, Casas, J, Metherell, L, Zakaa Khaled, Hall, C, Khaled, Zakaa, Palazzo, F   +44 more
core   +1 more source

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]

, 2012
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe, Fabbro, Doriano, Doriano Fabbro, Huwiler Andrea, Zangemeister-Wittke Uwe, Huwiler, Andrea, Uwe Zangemeister-Wittke, Kotelevets Nataliya, Nataliya Kotelevets (156133), Kotelevets, Nataliya, Nataliya Kotelevets, Andrea Huwiler, Doriano Fabbro (156139), Andrea Huwiler (156145), Uwe Zangemeister-Wittke (156150), Fabbro Doriano   +15 more
core   +1 more source