Results 31 to 40 of about 30,128 (249)
A real-time high-throughput fluorescence assay for sphingosine kinases
Journal of Lipid Research, 2014 Sphingosine kinases (SphKs), of which there are two isoforms, SphK1 and SphK2, have been implicated in regulation of many important cellular processes. We have developed an assay for monitoring SphK1 and SphK2 activity in real time without the need for ...
Santiago Lima +2 more
doaj +1 more source
Sphingosine Kinase 1 in Cancer [PDF]
, 2013 The role of sphingolipids as bioactive signaling molecules that can regulate cell fate decisions puts them at center stage for cancer treatment and prevention. While ceramide and sphingosine have been established as antigrowth molecules, sphingosine-1-phosphate (S1P) offers a progrowth message to cells.
Linda A, Heffernan-Stroud, Lina M, Obeid
openaire +2 more sources
Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
doaj +1 more source
PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner [PDF]
, 2013 Metabolic disorders are a major burden for public health systems globally. Regular exercise improves metabolic health. Pharmacological targeting of exercise mediators might facilitate physical activity or amplify the effects of exercise.
Shui, Guanghou +11 more
core +1 more source
PLoS ONE, 2015 Sphingosine kinase is a lipid kinase that converts sphingosine into sphingosine-1-phosphate, an important signaling molecule with intracellular and extracellular functions.
Yong-Seok Oh +5 more
doaj +1 more source
Dimethylsphingosine Regulates Intracellular pH and Ca2+ Human Monocytes
Journal of Pharmacological Sciences, 2006 .: Dimethylsphingosine (DMS) was first reported as an inhibitor of protein kinase C and later has been used as a specific inhibitor of sphingosine kinase.
Eun-Hee Lee +5 more
doaj +1 more source
Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors [PDF]
Trends in Pharmacological Sciences, 2017 The purpose of this Opinion is to present a case for targeting sphingosine kinase 2 (SK2) in autoimmune/inflammatory disease. Data obtained using Sphk2-/- mice suggest that SK2 is an anti-inflammatory enzyme, although this might be misleading because of a compensatory increase in the expression of a second isoform, sphingosine kinase 1 (SK1), which ...
Pyne, Nigel J. +2 more
openaire +4 more sources
Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.
PLoS ONE, 2018 Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies.
Yugesh Kharel +9 more
doaj +1 more source
Fingolimod modulates microglial activation to augment markers of remyelination [PDF]
, 2011 Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin +8 more
core +1 more source
Biomolecules, 2013 Ovarian cancer is a multigenic disease and molecular events driving ovarian cancer progression are not well established. We have previously reported the dysregulation of the cytoskeleton during ovarian cancer progression in a syngeneic mouse cell model ...
Eva M. Schmelz +4 more
doaj +1 more source