Results 31 to 40 of about 526,512 (229)
Biomolecules, 2013 Ovarian cancer is a multigenic disease and molecular events driving ovarian cancer progression are not well established. We have previously reported the dysregulation of the cytoskeleton during ovarian cancer progression in a syngeneic mouse cell model ...
Eva M. Schmelz +4 more
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Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors.
PLoS ONE, 2018 Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies.
Yugesh Kharel +9 more
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Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
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Dimethylsphingosine Regulates Intracellular pH and Ca2+ Human Monocytes
Journal of Pharmacological Sciences, 2006 .: Dimethylsphingosine (DMS) was first reported as an inhibitor of protein kinase C and later has been used as a specific inhibitor of sphingosine kinase.
Eun-Hee Lee +5 more
doaj +1 more source
Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Timothy, Rohrbach +2 more
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Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases
Liver Research, 2019 The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
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Sphingosine Kinase 1 in Cancer [PDF]
, 2013 The role of sphingolipids as bioactive signaling molecules that can regulate cell fate decisions puts them at center stage for cancer treatment and prevention. While ceramide and sphingosine have been established as antigrowth molecules, sphingosine-1-phosphate (S1P) offers a progrowth message to cells.
Linda A, Heffernan-Stroud, Lina M, Obeid
openaire +2 more sources
Frontiers in Oncology, 2012 There is substantial evidence for a role in cancer of the bioactive lipid sphingosine 1-phosphate (S1P), the enzyme sphingosine kinase 1 (that catalyses S1P formation) and S1P-specific G protein coupled receptors.
Susan ePyne +3 more
doaj +1 more source
Current Oncology, 2023 Mitophagy plays an important role in maintaining mitochondrial homeostasis by clearing damaged mitochondria. Sphingosine kinase 2 (SK2), a type of sphingosine kinase, is an important metabolic enzyme involved in generating sphingosine-1-phosphate.
Jian Wu +5 more
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PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner [PDF]
, 2013 Metabolic disorders are a major burden for public health systems globally. Regular exercise improves metabolic health. Pharmacological targeting of exercise mediators might facilitate physical activity or amplify the effects of exercise.
Shui, Guanghou +11 more
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