Results 41 to 50 of about 27,038 (199)
Sphingosine Kinase 1 in Cancer [PDF]
, 2013 The role of sphingolipids as bioactive signaling molecules that can regulate cell fate decisions puts them at center stage for cancer treatment and prevention. While ceramide and sphingosine have been established as antigrowth molecules, sphingosine-1-phosphate (S1P) offers a progrowth message to cells.
Linda A, Heffernan-Stroud, Lina M, Obeid
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Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Timothy, Rohrbach +2 more
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N,N-Dimethyl-D-erythro-Sphingosine Inhibits Store-Operated Ca2+ Entry in U937 Monocytes
Journal of Pharmacological Sciences, 2008 Calcium is a ubiquitous second messenger that controls a broad range of cellular functions, and store-operated calcium entry (SOCE) is the primary mechanism of regulated Ca2+ entry in non-excitable immunocytes. In this study, we found that N,N-dimethyl-D-
Ji-Yeong Jo +6 more
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Transcriptional Regulation of Sphingosine Kinase 1
Cells, 2020 Once thought to be primarily structural in nature, sphingolipids have become increasingly appreciated as second messengers in a wide array of signaling pathways.
Joseph Bonica +3 more
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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation [PDF]
Advances in Biological Regulation, 2016 Sphingosine kinase (there are two isoforms, SK1 and SK2) catalyses the formation of sphingosine 1-phosphate (S1P), a bioactive lipid that can be released from cells to activate a family of G protein-coupled receptors, termed S1P1-5. In addition, S1P can bind to intracellular target proteins, such as HDAC1/2, to induce cell responses.
Pyne, Nigel J. +8 more
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Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
Cell Reports, 2016 Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis; however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in endocytic trafficking has not been established. Here, we demonstrate that
Megan M. Young +5 more
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eLife, 2017 Sphingosine-1-phosphate (S1P) is generated through phosphorylation of sphingosine by sphingosine kinases (Sphk1 and Sphk2). We show that sphk2 maternal-zygotic mutant zebrafish embryos (sphk2MZ) display early developmental phenotypes, including a delay ...
Karen Mendelson +6 more
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Frontiers in Molecular Biosciences, 2021 Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii +7 more
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Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors [PDF]
Trends in Pharmacological Sciences, 2017 The purpose of this Opinion is to present a case for targeting sphingosine kinase 2 (SK2) in autoimmune/inflammatory disease. Data obtained using Sphk2-/- mice suggest that SK2 is an anti-inflammatory enzyme, although this might be misleading because of a compensatory increase in the expression of a second isoform, sphingosine kinase 1 (SK1), which ...
Pyne, Nigel J. +2 more
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Journal of International Medical Research, 2021 Objective This study examined whether the immunomodulator fingolimod (FTY720) could alleviate renal ischemia/reperfusion (I/R)-induced lung injury and explored the potential mechanisms. Methods Renal I/R was established in a rat model, and FTY720 (0.5, 1,
Zu-an Shi +4 more
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