Results 11 to 20 of about 57,421 (279)

Cellular signalling by sphingosine kinase and sphingosine 1‐phosphate [PDF]

IUBMB Life, 2006
AbstractSphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1‐phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular maturation. The last few years have seen a number of significant advances in understanding of the
Leclercq, T., Pitson, S.
openaire   +4 more sources

Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection

Infection and Drug Resistance, 2023
Qian Qi,1,2,* Jiawei Xu,1,2,* Yujiao Wang,3,* Jian Zhang,1 Mingxia Gao,1 Yu Li,4 Liang Dong1,2 1Department of Respiratory, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong ...
Qi Q, Xu J, Wang Y, Zhang J, Gao M, Li Y, Dong L   +6 more
doaj   +1 more source

Recycling of Sphingosine Is Regulated by the Concerted Actions of Sphingosine-1-phosphate Phosphohydrolase 1 and Sphingosine Kinase 2 [PDF]

Journal of Biological Chemistry, 2007
In yeast, the long-chain sphingoid base phosphate phosphohydrolase Lcb3p is required for efficient ceramide synthesis from exogenous sphingoid bases. Similarly, in this study, we found that incorporation of exogenous sphingosine into ceramide in mammalian cells was regulated by the homologue of Lcb3p, sphingosine-1-phosphate phosphohydrolase 1 (SPP-1),
Hervé, Le Stunff, Paola, Giussani, Michael, Maceyka, Sandrine, Lépine, Sheldon, Milstien, Sarah, Spiegel   +5 more
openaire   +3 more sources

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer [PDF]

Discover Oncology, 2021
AbstractSphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intracellularly produced S1P is delivered to the extracellular
Guangmeng Xu, Zecheng Yang, Yamin Sun, Hongmei Dong, Jingru Ma   +4 more
openaire   +3 more sources

Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 Infection

The Thoracic & Cardiovascular Surgeon Reports, 2022
Background The majority of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection present mild symptoms. However, some patients develop severe acute respiratory distress syndrome (ARDS) and subsequent irreversible lung ...
Achim Koch, Nikolaus Pizanis, Vasiliki Bessa, Frank Herbstreit, Erich Gulbins, Clemens Aigner, Markus Kamler   +6 more
doaj   +1 more source

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat

Frontiers in Immunology, 2017
Sepsis is not only a significant cause of mortality worldwide but has particularly devastating effects on the central nervous system of survivors. It is therefore crucial to understand the molecular structure, physiology, and events involved in the ...
Stephen J. Kuperberg, Raj Wadgaonkar
doaj   +1 more source

Sphingosine 1-phosphate in renal diseases [PDF]

, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Pfeilschrifter, Josef, Koch, Alexander, Alexander Koch, Josef Pfeilschifter, Pfeilschifter, Josef, Huwiler, Andrea, Andrea Huwiler   +6 more
core   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection [PDF]

Journal of Cardiovascular Pharmacology, 2009
Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset ...
openaire   +2 more sources

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]

, 2012
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe, Fabbro, Doriano, Doriano Fabbro, Huwiler Andrea, Zangemeister-Wittke Uwe, Huwiler, Andrea, Uwe Zangemeister-Wittke, Kotelevets Nataliya, Nataliya Kotelevets (156133), Kotelevets, Nataliya, Nataliya Kotelevets, Andrea Huwiler, Doriano Fabbro (156139), Andrea Huwiler (156145), Uwe Zangemeister-Wittke (156150), Fabbro Doriano   +15 more
core   +1 more source